The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Enhanced Stability and Controlled Delivery of MOF-Encapsulated Vaccines and Their Immunogenic Response In Vivo
Open accessAbstract
Vaccines have an innate tendency to lose their structural conformation upon environmental and chemical stressors. A loss in conformation reduces the therapeutic ability to prevent the spread of a pathogen. Herein, we report an in-depth study of zeolitic imidazolate framework-8 and its ability to provide protection for a model viral vector against denaturing conditions. The immunoassay and spectroscopy analysis together demonstrate enhanced thermal and chemical stability to the conformational structure of the encapsulated viral nanoparticle. The long-term biological activity of this virus-ZIF composite was investigated in animal models to further elucidate the integrity of the encapsulated virus, the biosafety, and immunogenicity of the overall composite. Additionally, histological analysis found no observable tissue damage in the skin or vital organs in mice, following multiple subcutaneous administrations. This study shows that ZIF-based protein composites are strong candidates for improved preservation of proteinaceous drugs, are biocompatible, and are capable of controlling the release and adsorption of drugs in vivo.
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Citations
Cites
Protein Therapeutics: A Summary and Pharmacological Classification
Leader, B., Baca, Q. J., & Golan, D. E. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2399 · Cited by 2,161
Alsaiari, S. K., Patil, S., Alyami, M., Alamoudi, K. O., Aleisa, F. A., Merzaban, J. S., Li, M., & Khashab, N. M. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11754 · Cited by 517
Maurer, P., Jennings, G. T., Willers, J., Rohner, F., Lindman, Y., Roubicek, K., Renner, W. A., Müller, P., & Bachmann, M. F. (2005) · European Journal of Immunology · doi:10.1002/eji.200526285 · Cited by 279
Cited by
Metal–Organic Frameworks for Drug Delivery: A Design Perspective
Lawson, H. D., Walton, S. P., & Chan, C. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c01089 · Cited by 916
Viral Nanoparticles for Drug Delivery, Imaging, Immunotherapy, and Theranostic Applications
Chung, Y. H., Cai, H., & Steinmetz, N. F. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.024 · Cited by 391
Multifunctional metal–organic framework heterostructures for enhanced cancer therapy
Liu, J., Huang, J., Zhang, L., & Lei, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00178c · Cited by 285
Advances in immunomodulatory MOFs for biomedical applications
Zhang, B., Chen, J., Zhu, Z., Zhang, X., & Wang, J. (2024) · Small · doi:10.1002/smll.202307299 · Cited by 31
Metadata
- Authors
- Luzuriaga, M. A., Welch, R. P., Dharmarwardana, M., Benjamin, C. E., Li, S., Shahrivarkevishahi, A., Popal, S., Tuong, L. H., Creswell, C. T., & Gassensmith, J. J.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-02-19
- Volume
- 11
- Issue
- 10
- Pages
- 9740-9746
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2917632841
- Cited by
- 166
- References
- 3
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Luzuriaga, M. A., Welch, R. P., Dharmarwardana, M., Benjamin, C. E., Li, S., Shahrivarkevishahi, A., Popal, S., Tuong, L. H., Creswell, C. T., & Gassensmith, J. J. (2019). Enhanced Stability and Controlled Delivery of MOF-Encapsulated Vaccines and Their Immunogenic Response In Vivo. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.8b20504
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