Viral Nanoparticles for Drug Delivery, Imaging, Immunotherapy, and Theranostic Applications

Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures

Pushko, P., Pumpens, P., & Grens, E. (2013) · Intervirology · doi:10.1159/000346773 · Cited by 5,970 · see citing works

The antibiotic resistance crisis: part 1: causes and threats.

Ventola, C. L. (2015) · PubMed Central · Cited by 4,558 · see citing works

Innate and adaptive immune cells in the tumor microenvironment

Gajewski, T. F., Schreiber, H., & Fu, Y.-X. (2013) · Nature Immunology · doi:10.1038/ni.2703 · Cited by 4,148 · see citing works

Tumour heterogeneity and resistance to cancer therapies

Dagogo-Jack, I., & Shaw, A. T. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.166 · Cited by 3,846 · see citing works

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works

Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Liu, Y., Bhattarai, P., Dai, Z., & Chen, X. S. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00618k · Cited by 2,918 · see citing works

Advances and Challenges of Liposome Assisted Drug Delivery

Sercombe, L., Veerati, T., Moheimani, F., Wu, S. Y., Sood, A. K., & Hua, S. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00286 · Cited by 2,672 · see citing works

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

Johnstone, T. C., Suntharalingam, K., & Lippard, S. J. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00597 · Cited by 2,489 · see citing works

Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns

Bachmann, M. F., & Jennings, G. T. (2010) · Nature reviews. Immunology · doi:10.1038/nri2868 · Cited by 2,120 · see citing works

Nanoparticle PEGylation for Imaging and Therapy

Jokerst, J. V., Lobovkina, T., Zare, R. N., & Gambhir, S. S. (2011) · Nanomedicine · doi:10.2217/nnm.11.19 · Cited by 2,054 · see citing works

Copper Selenide Nanocrystals for Photothermal Therapy

Hessel, C. M., Pattani, V. P., Rasch, M. R., Panthani, M. G., Koo, B., Tunnell, J. W., & Korgel, B. A. (2011) · Nano Letters · doi:10.1021/nl201400z · Cited by 1,455 · see citing works

Personalized vaccines for cancer immunotherapy

Şahin, U., & Türeci, Ö. (2018) · Science · doi:10.1126/science.aar7112 · Cited by 1,162 · see citing works

Host–guest encapsulation of materials by assembled virus protein cages

Douglas, T., & Young, M. (1998) · Nature · doi:10.1038/30211 · Cited by 906 · see citing works

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

Kanekiyo, M., Wei, C., Yassine, H. M., McTamney, P. M., Boyington, J. C., Whittle, J. R. R., Rao, S. S., Kong, W., Wang, L., & Nabel, G. J. (2013) · Nature · doi:10.1038/nature12202 · Cited by 887 · see citing works

Near-infrared light-responsive nanomaterials in cancer therapeutics

Shanmugam, V., Selvakumar, S., & Yeh, C. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00011k · Cited by 873 · see citing works

Protein-based nanocarriers as promising drug and gene delivery systems

Elzoghby, A. O., Samy, W. M., & Elgindy, N. A. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.036 · Cited by 855 · see citing works

Gold nanorods: Their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions

Alkilany, A. M., Thompson, L. B., Boulos, S. P., Sisco, P. N., & Murphy, C. J. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.03.005 · Cited by 806 · see citing works

Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms

Rogosnitzky, M., & Branch, S. (2016) · BioMetals · doi:10.1007/s10534-016-9931-7 · Cited by 769 · see citing works

Resident memory CD8 T cells trigger protective innate and adaptive immune responses

Schenkel, J. M., Fraser, K. A., Beura, L. K., Pauken, K. E., Vezys, V., & Masopust, D. (2014) · Science · doi:10.1126/science.1254536 · Cited by 731 · see citing works

Integrating oncolytic viruses in combination cancer immunotherapy

Bommareddy, P. K., Shettigar, M., & Kaufman, H. L. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0014-6 · Cited by 704 · see citing works

Recent advances of cocktail chemotherapy by combination drug delivery systems

Hu, Q., Sun, W., Wang, C., & Gu, Z. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.022 · Cited by 625 · see citing works

Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment

Wang, Y., Black, K. C. L., Luehmann, H. P., Li, W., Zhang, Y. S., Cai, X., Wan, D., Liu, S.-Y., Li, M., Kim, P. M., et al. (2013) · ACS Nano · doi:10.1021/nn304332s · Cited by 616 · see citing works

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design

Burton, D. R., & Hangartner, L. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055515 · Cited by 585 · see citing works

Residue-Specific Peptide Modification: A Chemist’s Guide

deGruyter, J. N., Malins, L. R., & Baran, P. S. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00536 · Cited by 571 · see citing works

Major findings and recent advances in virus–like particle (VLP)-based vaccines

Mohsen, M. O., Zha, L., Cabral‐Miranda, G., & Bachmann, M. F. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.08.014 · Cited by 560 · see citing works

The race for coronavirus vaccines: a graphical guide

Callaway, E. (2020) · Nature · doi:10.1038/d41586-020-01221-y · Cited by 492 · see citing works

In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer

Lizotte, P. H., Wen, A. M., Sheen, M. R., Fields, J., Rojanasopondist, P., Steinmetz, N. F., & Fiering, S. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.292 · Cited by 484 · see citing works

A virus-based single-enzyme nanoreactor

Comellas-Aragonès, M., Engelkamp, H., Claessen, V. I., Sommerdijk, N. A. J. M., Rowan, A. E., Christianen, P. C. M., Maan, J. C., Verduin, B. J. M., Cornelissen, J. J. L. M., & Nolte, R. J. M. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.299 · Cited by 429 · see citing works

A novel intracellular protein delivery platform based on single-protein nanocapsules

Yan, M., Du, J., Gu, Z., Liang, M., Hu, Y., Zhang, W., Priceman, S. J., Wu, L., Zhou, Z. H., Liu, Z., et al. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.341 · Cited by 424 · see citing works

Virus-based nanocarriers for drug delivery

Ma, Y., Nolte, R. J. M., & Cornelissen, J. J. L. M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.005 · Cited by 422 · see citing works

Paramagnetic lanthanide complexes as PARACEST agents for medical imaging

Woods, M., Woessner, D. E., & Sherry, A. D. (2006) · Chemical Society Reviews · doi:10.1039/b509907m · Cited by 394 · see citing works

Biomineralization-Inspired Synthesis of Copper Sulfide–Ferritin Nanocages as Cancer Theranostics

Wang, Z., Huang, P., Jacobson, O., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b07521 · Cited by 381 · see citing works

Design of virus-based nanomaterials for medicine, biotechnology, and energy

Wen, A. M., & Steinmetz, N. F. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00287g · Cited by 378 · see citing works

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

Samson, A., Scott, K. J., Taggart, D., West, E. J., Wilson, E., Nuovo, G. J., Thomson, S., Corns, R. A., Mathew, R. K., Fuller, M. J., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aam7577 · Cited by 376 · see citing works

Self-Assembling Light-Harvesting Systems from Synthetically Modified Tobacco Mosaic Virus Coat Proteins

Miller, R. A., Presley, A. D., & Francis, M. B. (2007) · Journal of the American Chemical Society · doi:10.1021/ja063887t · Cited by 373 · see citing works

2019 novel coronavirus (2019-nCoV) outbreak: A new challenge

Lupia, T., Scabini, S., Pinna, S. M., Perri, G. D., Rosa, F. G. D., & Corcione, S. (2020) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2020.02.021 · Cited by 369 · see citing works

Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site

Kanekiyo, M., Bu, W., Joyce, M. G., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.043 · Cited by 367 · see citing works

Cell-Specific Delivery of Diverse Cargos by Bacteriophage MS2 Virus-like Particles

Ashley, C. E., Carnes, E. C., Phillips, G. K., Durfee, P. N., Buley, M. D., Lino, C. A., Padilla, D. P., Phillips, B., Carter, M. B., Willman, C. L., et al. (2011) · ACS Nano · doi:10.1021/nn201397z · Cited by 350 · see citing works

Talimogene laherparepvec: First in class oncolytic virotherapy

Conry, R. M., Westbrook, B., McKee, S., & Norwood, T. G. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2017.1412896 · Cited by 335 · see citing works

Platelet Expression Profiling and Clinical Validation of Myeloid-Related Protein-14 as a Novel Determinant of Cardiovascular Events

Healy, A. M., Pickard, M. D., Pradhan, A. D., Wang, Y., Chen, Z., Croce, K., Sakuma, M., Shi, C., Zago, A. C., Garasic, J. M., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.607333 · Cited by 333 · see citing works

Talimogene Laherparepvec (T-VEC) and Other Oncolytic Viruses for the Treatment of Melanoma

Bommareddy, P. K., Patel, A. V., Hossain, S., & Kaufman, H. L. (2016) · American Journal of Clinical Dermatology · doi:10.1007/s40257-016-0238-9 · Cited by 323 · see citing works

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

Tokatlian, T., Read, B. J., Jones, C. A., Kulp, D. W., Menis, S., Chang, J. Y. H., Steichen, J. M., Kumari, S., Allen, J. D., Dane, E. L., et al. (2018) · Science · doi:10.1126/science.aat9120 · Cited by 307 · see citing works

Iron/iron oxide core/shell nanoparticles for magnetic targeting MRI and near-infrared photothermal therapy

Zhou, Z., Sun, Y., Shen, J., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.063 · Cited by 305 · see citing works

High Neutrophil Numbers in Human Carotid Atherosclerotic Plaques Are Associated With Characteristics of Rupture-Prone Lesions

Ionita, M. G., van den Borne, P., Catanzariti, L. M., Moll, F. L., de Vries, J. P. P. M., Pasterkamp, G., Vink, A., & de Kleijn, D. P. V. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.209296 · Cited by 304 · see citing works

The Shape of Things to Come: Importance of Design in Nanotechnology for Drug Delivery

Liu, Y., Tan, J., Thomas, A., Ou-Yang, D., & Muzykantov, V. R. (2012) · Therapeutic Delivery · doi:10.4155/tde.11.156 · Cited by 298 · see citing works

Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy

Bourgeois‐Daigneault, M., Roy, D. G., Aitken, A. S., El-Sayes, N., Martin, N. T., Varette, O., Falls, T. J., St-Germain, L. E., Pelin, A., Lichty, B. D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao1641 · Cited by 291 · see citing works

Nonmethylated CG Motifs Packaged into Virus-Like Particles Induce Protective Cytotoxic T Cell Responses in the Absence of Systemic Side Effects

Storni, T., Ruedl, C., Schwarz, K., Schwendener, R. A., Renner, W. A., & Bachmann, M. F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1777 · Cited by 287 · see citing works

Antibiotic Resistance Crisis

Mobarki, N., Almerabi, B., & Hattan, A. (2019) · International Journal of Medicine in Developing Countries · doi:10.24911/ijmdc.51-1549060699 · Cited by 269 · see citing works

The photoreversible fluorescent protein iLOV outperforms GFP as a reporter of plant virus infection

Chapman, S. N., Faulkner, C. R., Kaiserli, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807551105 · Cited by 264 · see citing works

Viral nanoparticles as platforms for next-generation therapeutics and imaging devices

Steinmetz, N. F. (2010) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2010.04.005 · Cited by 259 · see citing works

First Demonstration of Gold Nanorods‐Mediated Photodynamic Therapeutic Destruction of Tumors via Near Infra‐Red Light Activation

Vankayala, R., Huang, Y., Kalluru, P., Chiang, C., & Hwang, K. C. (2013) · Small · doi:10.1002/smll.201302719 · Cited by 243 · see citing works

Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen–specific CTLs

Brown, M. C., Holl, E. K., Boczkowski, D., Dobrikova, E. Y., Mosaheb, M., Chandramohan, V., Bigner, D. D., Gromeier, M., & Nair, S. K. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan4220 · Cited by 226 · see citing works

Explanations for the high potency of HPV prophylactic vaccines

Schiller, J. T., & Lowy, D. R. (2018) · Vaccine · doi:10.1016/j.vaccine.2017.12.079 · Cited by 226 · see citing works

Protein delivery using engineered virus-like particles

Kaczmarczyk, S. J., Sitaraman, K., Young, H. A., Hughes, S. H., & Chatterjee, D. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101874108 · Cited by 220 · see citing works

Safety of Thrombolysis in Acute Ischemic Stroke: A Review of Complications, Risk Factors, and Newer Technologies

Miller, D. J., Simpson, J. R., & Silver, B. (2011) · The Neurohospitalist · doi:10.1177/1941875211408731 · Cited by 219 · see citing works

Current status of granulocyte–macrophage colony-stimulating factor in the immunotherapy of melanoma

Kaufman, H. L., Ruby, C. E., Hughes, T. M., & Slingluff, C. L. (2014) · Journal for ImmunoTherapy of Cancer · doi:10.1186/2051-1426-2-11 · Cited by 211 · see citing works

Folic Acid-Conjugated Protein Cages of a Plant Virus: A Novel Delivery Platform for Doxorubicin

Ren, Y., Wong, S. M., & Lim, L. Y. (2007) · Bioconjugate Chemistry · doi:10.1021/bc060361p · Cited by 208 · see citing works

Vaccination against IL‐17 suppresses autoimmune arthritis and encephalomyelitis

Röhn, T. A., Jennings, G. T., Hernandez, M., Grest, P., Beck, M., Zou, Y., Köpf, M., & Bachmann, M. F. (2006) · European Journal of Immunology · doi:10.1002/eji.200636658 · Cited by 195 · see citing works

Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

Sliepen, K., Ozorowski, G., Burger, J. A., et al. (2015) · Retrovirology · doi:10.1186/s12977-015-0210-4 · Cited by 185 · see citing works

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

Brouwer, P. J. M., Antanasijevic, A., Berndsen, Z. T., Yasmeen, A., Fiala, B., Bijl, T. P. L., Bontjer, I., Bale, J. B., Sheffler, W., Allen, J. D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12080-1 · Cited by 185 · see citing works

Functional Virus-Based Polymer–Protein Nanoparticles by Atom Transfer Radical Polymerization

Pokorski, J. K., Breitenkamp, K., Liepold, L. O., Qazi, S., & Finn, M. G. (2011) · Journal of the American Chemical Society · doi:10.1021/ja203286n · Cited by 183 · see citing works

Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System

Mohsen, M. O., Gomes, A. C., Vogel, M., & Bachmann, M. F. (2018) · Vaccines · doi:10.3390/vaccines6030037 · Cited by 183 · see citing works

Use of the interior cavity of the P22 capsid for site-specific initiation of atom-transfer radical polymerization with high-density cargo loading

Lucon, J., Qazi, S., Uchida, M., et al. (2012) · Nature Chemistry · doi:10.1038/nchem.1442 · Cited by 179 · see citing works

Genetically Programmed In Vivo Packaging of Protein Cargo and Its Controlled Release from Bacteriophage P22

O’Neil, A., Reichhardt, C., Johnson, B., Prevelige, P. E., & Douglas, T. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201102036 · Cited by 168 · see citing works

Enhanced Stability and Controlled Delivery of MOF-Encapsulated Vaccines and Their Immunogenic Response In Vivo

Luzuriaga, M. A., Welch, R. P., Dharmarwardana, M., Benjamin, C., Li, S., Shahrivarkevishahi, A., Popal, S., Tuong, L. H., Creswell, C., & Gassensmith, J. J. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b20504 · Cited by 166 · see citing works

Improved Stable Indocyanine Green (ICG)‐Mediated Cancer Optotheranostics with Naturalized Hepatitis B Core Particles

Shan, W., Chen, R., Zhang, Q., Zhao, J., Chen, B., Zhou, X., Ye, S., Bi, S., Nie, L., & Ren, L. (2018) · Advanced Materials · doi:10.1002/adma.201707567 · Cited by 165 · see citing works

Dual-Modal Magnetic Resonance and Fluorescence Imaging of Atherosclerotic Plaques in Vivo Using VCAM-1 Targeted Tobacco Mosaic Virus

Bruckman, M. A., Jiang, K., Simpson, E. J., Randolph, L. N., Luyt, L. G., Yu, X., & Steinmetz, N. F. (2014) · Nano Letters · doi:10.1021/nl404816m · Cited by 165 · see citing works

Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence

Song, C., Phuengkham, H., Kim, Y. S., Dinh, V. V., Lee, I., Shin, I. W., Shin, H. S., Jin, S. M., Um, S. H., Lee, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11730-8 · Cited by 161 · see citing works

Virus-Based Nanoparticles as Versatile Nanomachines

Koudelka, K. J., Pitek, A. S., Manchester, M., & Steinmetz, N. F. (2015) · Annual Review of Virology · doi:10.1146/annurev-virology-100114-055141 · Cited by 159 · see citing works

Targeting Antibacterial Agents by Using Drug-Carrying Filamentous Bacteriophages

Yacoby, I., Shamis, M., Bar, H., Shabat, D., & Benhar, I. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00169-06 · Cited by 151 · see citing works

A cholesterol-lowering VLP vaccine that targets PCSK9

Crossey, E., Amar, M. J., Sampson, M. L., Peabody, J., Schiller, J. T., Chackerian, B., & Remaley, A. T. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.09.044 · Cited by 148 · see citing works

Chemical Modification of Viruses and Virus-Like Particles

Strable, E., & Finn, M. G. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-69379-6_1 · Cited by 143 · see citing works

Recent Advances on Inorganic Nanoparticle-Based Cancer Therapeutic Agents

Wang, F., Li, C., Cheng, J., & Yuan, Z. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13121182 · Cited by 143 · see citing works

Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles

Leong, H. S., Steinmetz, N. F., Ablack, A. L., et al. (2010) · Nature Protocols · doi:10.1038/nprot.2010.103 · Cited by 142 · see citing works

Virus-like particles as vaccine.

Chroboczek, J., Szurgot, I., & Szołajska, E. (2014) · Acta Biochimica Polonica · doi:10.18388/abp.2014_1875 · Cited by 142 · see citing works

Potentiating Cancer Immunotherapy Using Papaya Mosaic Virus-Derived Nanoparticles

Lebel, M., Chartrand, K., Tarrab, E., Savard, P. E., Leclerc, D., & Lamarre, A. (2016) · Nano Letters · doi:10.1021/acs.nanolett.5b04877 · Cited by 138 · see citing works

Drug delivery systems based on intrinsically conducting polymers

Puiggalí‐Jou, A., del Valle, L. J., & Alemán, C. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.07.035 · Cited by 138 · see citing works

Nanocoating for biomolecule delivery using layer-by-layer self-assembly

Keeney, M. G., Jiang, X., Yamane, M., et al. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00450k · Cited by 136 · see citing works

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

Sliepen, K., Han, B. W., Bontjer, I., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10262-5 · Cited by 135 · see citing works

Osmolyte-Mediated Encapsulation of Proteins inside MS2 Viral Capsids

Glasgow, J. E., Capehart, S. L., Francis, M. B., et al. (2012) · ACS Nano · doi:10.1021/nn302183h · Cited by 134 · see citing works

Potato virus X, a filamentous plant viral nanoparticle for doxorubicin delivery in cancer therapy

Le, D. H. T., Lee, K. L., Shukla, S., et al. (2017) · Nanoscale · doi:10.1039/c6nr09099k · Cited by 134 · see citing works

MEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation

Bommareddy, P. K., Aspromonte, S. M., Zloza, A., Rabkin, S. D., & Kaufman, H. L. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aau0417 · Cited by 133 · see citing works

Tumor-Specific Bacteriophages Induce Tumor Destruction through Activation of Tumor-Associated Macrophages

Eriksson, F., Tsagozis, P., Lundberg, K., Parsa, R., Mangsbo, S. M., Persson, M. A. A., Harris, R. A., & Pisa, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0800224 · Cited by 130 · see citing works

Treatment of Canine Oral Melanoma with Nanotechnology-Based Immunotherapy and Radiation

Hoopes, P. J., Wagner, R. J., Duval, K. E. A., Kang, K., Gladstone, D. J., Moodie, K. L., Crary-Burney, M., Arias‐Pulido, H., Veliz, F. A., Steinmetz, N. F., et al. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00126 · Cited by 125 · see citing works

Virus-like particle display of HER2 induces potent anti-cancer responses

Palladini, A., Thrane, S., Janitzek, C. M., Pihl, J., Clemmensen, S. B., de Jongh, W. A., Clausen, T. M., Nicoletti, G., Landuzzi, L., Penichet, M. L., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1408749 · Cited by 124 · see citing works

Intratumoral delivery of inactivated modified vaccinia virus Ankara (iMVA) induces systemic antitumor immunity via STING and Batf3-dependent dendritic cells

Dai, P., Wang, W., Yang, N., Serna‐Tamayo, C., Ricca, J. M., Zamarin, D., Shuman, S., Merghoub, T., Wolchok, J. D., & Deng, L. (2017) · Science Immunology · doi:10.1126/sciimmunol.aal1713 · Cited by 123 · see citing works

Hydrophobic chirality amplification in confined water cages

Song, C. E., Park, S. J., Hwang, I.-S., Jung, M. J., Shim, S. Y., Bae, H. Y., & Jung, J. Y. (2019) · Nature Communications · doi:10.1038/s41467-019-08792-z · Cited by 122 · see citing works

Intracellular Biodegradation of Ag Nanoparticles, Storage in Ferritin, and Protection by a Au Shell for Enhanced Photothermal Therapy

Espinosa, A., Curcio, A., Cabana, S., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b00482 · Cited by 122 · see citing works

Bioinspired Shielding Strategies for Nanoparticle Drug Delivery Applications

Gulati, N. M., Stewart, P. L., & Steinmetz, N. F. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00292 · Cited by 119 · see citing works

Refactored M13 Bacteriophage as a Platform for Tumor Cell Imaging and Drug Delivery

Ghosh, D., Kohli, A. G., Moser, F., et al. (2012) · ACS Synthetic Biology · doi:10.1021/sb300052u · Cited by 114 · see citing works

In Vivo Targeting and Imaging of Atherosclerosis Using Multifunctional Virus-Like Particles of Simian Virus 40

Sun, X., Li, W., Zhang, X., Qi, M., Zhang, Z., Zhang, X., & Cui, Z. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b02386 · Cited by 112 · see citing works

Plant viral nanoparticles-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers

Shukla, S., Myers, J., Woods, S. E., Gong, X., Czapar, A. E., Commandeur, U., Huang, A. Y.-C., Levine, A. D., & Steinmetz, N. F. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.12.030 · Cited by 112 · see citing works

In Situ Vaccination with Cowpea vs Tobacco Mosaic Virus against Melanoma

Murray, A. A., Wang, C., Fiering, S., & Steinmetz, N. F. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00316 · Cited by 112 · see citing works

VLPs Displaying a Single L2 Epitope Induce Broadly Cross-Neutralizing Antibodies against Human Papillomavirus

Tumban, E., Peabody, J., Tyler, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049751 · Cited by 111 · see citing works

Use of plant viruses and virus-like particles for the creation of novel vaccines

Baļķe, I., & Zeltiņš, A. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.08.007 · Cited by 107 · see citing works

Synthetic plant virology for nanobiotechnology and nanomedicine

Steele, J. F. C., Peyret, H., Saunders, K., et al. (2017) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1447 · Cited by 106 · see citing works

Dysprosium-Modified Tobacco Mosaic Virus Nanoparticles for Ultra-High-Field Magnetic Resonance and Near-Infrared Fluorescence Imaging of Prostate Cancer

Hu, H., Zhang, Y., Shukla, S., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b04472 · Cited by 106 · see citing works

Messenger RNA vaccine based on recombinant MS2 virus‐like particles against prostate cancer

Li, J., Sun, Y., Jia, T., Zhang, R., Zhang, K., & Wang, L. (2013) · International Journal of Cancer · doi:10.1002/ijc.28482 · Cited by 103 · see citing works

Molecular Imaging of Cancer Cells Using a Bacteriophage‐Based 129Xe NMR Biosensor

Palaniappan, K. K., Ramirez, R. M., Bajaj, V. S., et al. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201300170 · Cited by 102 · see citing works

Combination of Plant Virus Nanoparticle-Based in Situ Vaccination with Chemotherapy Potentiates Antitumor Response

Lee, K. L., Murray, A. A., Le, D. H. T., Sheen, M. R., Shukla, S., Commandeur, U., Fiering, S., & Steinmetz, N. F. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b00107 · Cited by 101 · see citing works

The disassembly, reassembly and stability of CCMV protein capsids

Lavelle, L., Michel, J., & Gingery, M. (2007) · Journal of Virological Methods · doi:10.1016/j.jviromet.2007.07.020 · Cited by 100 · see citing works

Protective Epitope Discovery and Design of MUC1-based Vaccine for Effective Tumor Protections in Immunotolerant Mice

Wu, X., Yin, Z., McKay, C. S., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b08473 · Cited by 100 · see citing works

Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Qβ Capsids

Yin, Z., Comellas-Aragonès, M., Chowdhury, S., et al. (2013) · ACS Chemical Biology · doi:10.1021/cb400060x · Cited by 98 · see citing works

Removal of Divalent Cations Induces Structural Transitions in Red Clover Necrotic Mosaic Virus , Revealing a Potential Mechanism for RNA Release

Sherman, M. B., Guenther, R. H., Tama, F., et al. (2006) · Journal of Virology · doi:10.1128/jvi.01137-06 · Cited by 97 · see citing works

Reconstituted plant viral capsids can release genes to mammalian cells

Azizgolshani, O., Garmann, R. F., Cadena-Nava, R. D., et al. (2013) · Virology · doi:10.1016/j.virol.2013.03.001 · Cited by 96 · see citing works

Glycan-Targeted Virus-like Nanoparticles for Photodynamic Therapy

Rhee, J., Baksh, M. M., Nycholat, C. M., et al. (2012) · Biomacromolecules · doi:10.1021/bm300578p · Cited by 94 · see citing works

Study of Binding between Protein A and Immunoglobulin G Using a Surface Tension Probe

Yang, L., Biswas, M. E., & Chen, P. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74870-x · Cited by 93 · see citing works

PET Imaging and Biodistribution of Chemically Modified Bacteriophage MS2

Farkas, M. E., Aanei, I. L., Behrens, C. R., et al. (2012) · Molecular Pharmaceutics · doi:10.1021/mp3003754 · Cited by 91 · see citing works

Clinical and Translational Science

(2010) · Clinical and Translational Science · doi:10.1111/(issn)1752-8062 · Cited by 91 · see citing works

The Antitumor Efficacy of CpG Oligonucleotides is Improved by Encapsulation in Plant Virus‐Like Particles

Cai, H., Shukla, S., & Steinmetz, N. F. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201908743 · Cited by 90 · see citing works

Clinical Applications of PET and PET-CT

Anand, S., Singh, H., & Dash, A. (2009) · Medical Journal Armed Forces India · doi:10.1016/s0377-1237(09)80099-3 · Cited by 89 · see citing works

Cowpea Mosaic Virus Capsid: A Promising Carrier for the Development of Carbohydrate Based Antitumor Vaccines

Miermont, A., Barnhill, H. N., Strable, E., et al. (2008) · Chemistry - A European Journal · doi:10.1002/chem.200800203 · Cited by 89 · see citing works

HIV-1 vaccine design through minimizing envelope metastability

He, L., Kumar, S., Allen, J. D., Huang, D., Lin, X., Mann, C. J., Saye-Francisco, K. L., Copps, J., Sarkar, A., Blizard, G. S., et al. (2018) · Science Advances · doi:10.1126/sciadv.aau6769 · Cited by 89 · see citing works

Cowpea Mosaic Virus Promotes Anti‐Tumor Activity and Immune Memory in a Mouse Ovarian Tumor Model

Wang, C., Fiering, S., & Steinmetz, N. F. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201900003 · Cited by 88 · see citing works

Cowpea Mosaic Virus Nanoparticles and Empty Virus-Like Particles Show Distinct but Overlapping Immunostimulatory Properties

Wang, C., Beiss, V., & Steinmetz, N. F. (2019) · Journal of Virology · doi:10.1128/jvi.00129-19 · Cited by 88 · see citing works

Cowpea mosaic virus nanoparticles for cancer imaging and therapy

Beatty, P. H., & Lewis, J. D. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.04.005 · Cited by 86 · see citing works

Tobacco Mosaic Virus as a New Carrier for Tumor Associated Carbohydrate Antigens

Yin, Z., Nguyen, H. G. T., Chowdhury, S., Bentley, P. A., Bruckman, M. A., Miermont, A., Gildersleeve, J. C., Wang, Q., & Huang, X. (2012) · Bioconjugate Chemistry · doi:10.1021/bc300244a · Cited by 85 · see citing works

Tobacco mosaic virus-based protein nanoparticles and nanorods for chemotherapy delivery targeting breast cancer

Bruckman, M. A., Czapar, A. E., VanMeter, A., et al. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.045 · Cited by 85 · see citing works

Loading and Release Mechanism of Red Clover Necrotic Mosaic Virus Derived Plant Viral Nanoparticles for Drug Delivery of Doxorubicin

Cao, J., Guenther, R. H., Sit, T. L., Opperman, C., Lommel, S. A., & Crowe, J. A. (2014) · Small · doi:10.1002/smll.201400558 · Cited by 84 · see citing works

Design of a VLP-nanovehicle for CYP450 enzymatic activity delivery

Sánchez-Sánchez, L., Tapia‐Moreno, A., Moreno, K. O. J., et al. (2015) · Journal of Nanobiotechnology · doi:10.1186/s12951-015-0127-z · Cited by 84 · see citing works

Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models?

Miller, R. E., Block, J. A., & Malfait, A. (2016) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000354 · Cited by 83 · see citing works

Evaluation of Three Morphologically Distinct Virus-Like Particles as Nanocarriers for Convection-Enhanced Drug Delivery to Glioblastoma

Finbloom, J. A., Aanei, I. L., Bernard, J. M. L., et al. (2018) · Nanomaterials · doi:10.3390/nano8121007 · Cited by 82 · see citing works

Development of virus‐like particles for diagnostic and prophylactic biomedical applications

Schwarz, B. H., & Douglas, T. (2015) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1336 · Cited by 81 · see citing works

Radiation Therapy Combined with Cowpea Mosaic Virus Nanoparticle in Situ Vaccination Initiates Immune-Mediated Tumor Regression

Patel, R. B., Czapar, A. E., Fiering, S., et al. (2018) · ACS Omega · doi:10.1021/acsomega.8b00227 · Cited by 81 · see citing works

Delivery of siRNA therapeutics using cowpea chlorotic mottle virus-like particles

Lam, P., & Steinmetz, N. F. (2019) · Biomaterials Science · doi:10.1039/c9bm00785g · Cited by 80 · see citing works

Engineering of SV40-based nano-capsules for delivery of heterologous proteins as fusions with the minor capsid proteins VP2/3

Inoue, T., Kawano, M., Takahashi, R., et al. (2008) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2007.12.006 · Cited by 79 · see citing works

Chemotherapy pro-drug activation by biocatalytic virus-like nanoparticles containing cytochrome P450

Sánchez-Sánchez, L., Cadena-Nava, R. D., Palomares, L. A., Ruiz-Garcia, J., Koay, M. S. T., Cornelissen, J. J. L. M., & Vázquez-Duhalt, R. (2014) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2014.04.003 · Cited by 79 · see citing works

Initial Treatment of Venous Thromboembolism

McRae, S. J., & Ginsberg, J. S. (2004) · Circulation · doi:10.1161/01.cir.0000140904.52752.0c · Cited by 79 · see citing works

Towards protein-based viral mimetics for cancer therapies

Unzueta, U., Céspedes, M. V., Vázquez, E., Ferrer‐Miralles, N., Mangues, R., & Villaverde, A. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.02.007 · Cited by 78 · see citing works

The Red clover necrotic mosaic virus Capsid as a Multifunctional Cell Targeting Plant Viral Nanoparticle

Lockney, D. M., Guenther, R. N., Loo, L., et al. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100361z · Cited by 78 · see citing works

Peptide display on Potato virus X: molecular features of the coat protein-fused peptide affecting cell-to-cell and phloem movement of chimeric virus particles

Lico, C., Capuano, F., Renzone, G., et al. (2006) · Journal of General Virology · doi:10.1099/vir.0.82097-0 · Cited by 78 · see citing works

Tobacco Mosaic Virus-Delivered Cisplatin Restores Efficacy in Platinum-Resistant Ovarian Cancer Cells

Franke, C. E., Czapar, A. E., Patel, R. B., & Steinmetz, N. F. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00466 · Cited by 76 · see citing works

Heterologous Prime-Boost Enhances the Antitumor Immune Response Elicited by Plant-Virus-Based Cancer Vaccine

Cai, H., Shukla, S., Wang, C., Hema, M., & Steinmetz, N. F. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b01523 · Cited by 76 · see citing works

Plant Virus-Like Particle In Situ Vaccine for Intracranial Glioma Immunotherapy

Kerstetter-Fogle, A. E., Shukla, S., Wang, C., Beiss, V., Harris, P. L. R., Sloan, A. E., & Steinmetz, N. F. (2019) · Cancers · doi:10.3390/cancers11040515 · Cited by 76 · see citing works

Shape matters: the diffusion rates of TMV rods and CPMV icosahedrons in a spheroid model of extracellular matrix are distinct

Lee, K. L., Hubbard, L. C., Hern, S., Yıldız, İ., Gratzl, M., & Steinmetz, N. F. (2013) · Biomaterials Science · doi:10.1039/c3bm00191a · Cited by 74 · see citing works

Application of Plant Viruses as a Biotemplate for Nanomaterial Fabrication

Zhang, Y., Dong, Y., Zhou, J., et al. (2018) · Molecules · doi:10.3390/molecules23092311 · Cited by 74 · see citing works

Novel miR-122 delivery system based on MS2 virus like particle surface displaying cell-penetrating peptide TAT for hepatocellular carcinoma

Wang, G., Jia, T., Xu, X., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10681 · Cited by 72 · see citing works

Cancer Theranostic Applications of Albumin-Coated Tobacco Mosaic Virus Nanoparticles

Pitek, A. S., Hu, H., Shukla, S., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b12499 · Cited by 71 · see citing works

Plant Virus Particles Carrying Tumour Antigen Activate TLR7 and Induce High Levels of Protective Antibody

Jobsri, J., Allen, A., Rajagopal, D., Shipton, M. J., Kanyuka, K., Lomonossoff, G. P., Ottensmeier, C. H. H., Diebold, S. S., Stevenson, F. K., & Savelyeva, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118096 · Cited by 70 · see citing works

Slow‐Release Formulation of Cowpea Mosaic Virus for In Situ Vaccine Delivery to Treat Ovarian Cancer

Czapar, A. E., Tiu, B. D. B., Veliz, F. A., Pokorski, J. K., & Steinmetz, N. F. (2018) · Advanced Science · doi:10.1002/advs.201700991 · Cited by 70 · see citing works

Integration of Cell-Penetrating Peptides with Rod-like Bionanoparticles: Virus-Inspired Gene-Silencing Technology

Tian, Y., Zhou, M., Shi, H., Gao, S., Xie, G., Zhu, M., Wu, M., Chen, J., & Niu, Z. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b01805 · Cited by 70 · see citing works

Viruses and Nanotechnology

Manchester, M., & Steinmetz, N. F. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-69379-6 · Cited by 68 · see citing works

Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs

Khan, D., & Ahmed, S. A. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00236 · Cited by 68 · see citing works

Cowpea Mosaic Virus Immunotherapy Combined with Cyclophosphamide Reduces Breast Cancer Tumor Burden and Inhibits Lung Metastasis

Cai, H., Wang, C., Shukla, S., & Steinmetz, N. F. (2019) · Advanced Science · doi:10.1002/advs.201802281 · Cited by 68 · see citing works

Delivery of self-amplifying RNA vaccines in in vitro reconstituted virus-like particles

Biddlecome, A. M., Habte, H. H., McGrath, K. M., Sambanthamoorthy, S., Wurm, M., Sykora, M. M., Knobler, C. M., Lorenz, I. C., Lasaro, M. O., Elbers, K., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215031 · Cited by 67 · see citing works

Antibody Response against Cowpea Mosaic Viral Nanoparticles Improves In Situ Vaccine Efficacy in Ovarian Cancer

Shukla, S., Wang, C., Beiss, V., et al. (2020) · ACS Nano · doi:10.1021/acsnano.9b07865 · Cited by 67 · see citing works

Synthesis and Immunological Evaluation of Disaccharide Bearing MUC-1 Glycopeptide Conjugates with Virus-like Particles

Wu, X., McKay, C. S., Pett, C., et al. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00381 · Cited by 66 · see citing works

CD47 Blockade and Cowpea Mosaic Virus Nanoparticle In Situ Vaccination Triggers Phagocytosis and Tumor Killing

Wang, C., & Steinmetz, N. F. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801288 · Cited by 63 · see citing works

Engineering protein self-assembling in protein-based nanomedicines for drug delivery and gene therapy

Ferrer-Miralles, N., Rodríguez‐Carmona, E., Corchero, J., García-Fruitós, E., Vázquez, E., & Villaverde, A. (2015) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2013.833163 · Cited by 63 · see citing works

Tobacco mosaic virus delivery of mitoxantrone for cancer therapy

Lin, R. D., & Steinmetz, N. F. (2018) · Nanoscale · doi:10.1039/c8nr04142c · Cited by 63 · see citing works

Viruslike Particles Encapsidating Respiratory Syncytial Virus M and M2 Proteins Induce Robust T Cell Responses

Schwarz, B. H., Morabito, K. M., Ruckwardt, T. J., et al. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00532 · Cited by 62 · see citing works

Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor

Dharmarwardana, M., Martins, A. F., Chen, Z., Palacios, P. M., Nowak, C. M., Welch, R. P., Li, S., Luzuriaga, M. A., Bleris, L. G., Pierce, B. S., et al. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00262 · Cited by 62 · see citing works

Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis

von Loga, I. S., El-Turabi, A., Jostins, L., Miotla‐Zarebska, J., Alderson, J., Zeltiņš, A., Parisi, I., Bachmann, M. F., & Vincent, T. L. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-214489 · Cited by 62 · see citing works

Multifunctionalized biocatalytic P22 nanoreactor for combinatory treatment of ER+ breast cancer

Chauhan, K., Hernández-Meza, J. M., Rodríguez‐Hernández, A. G., et al. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0345-2 · Cited by 61 · see citing works

Thermally-responsive Virus-like Particle for Targeted Delivery of Cancer Drug

Thong, Q. X., Biabanikhankahdani, R., Ho, K. L., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-40388-x · Cited by 61 · see citing works

Modularized peptides modified HBc virus-like particles for encapsulation and tumor-targeted delivery of doxorubicin

Shan, W., Zhang, D., Wu, Y., Lv, X., Hu, B., Zhou, X., Ye, S., Bi, S., Ren, L., & Zhang, X. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.12.002 · Cited by 60 · see citing works

Engineering the PP7 Virus Capsid as a Peptide Display Platform

Zhao, L., Kopylov, M., Potter, C. S., Carragher, B. O., & Finn, M. G. (2019) · ACS Nano · doi:10.1021/acsnano.8b09683 · Cited by 60 · see citing works

Biodistribution of Antibody-MS2 Viral Capsid Conjugates in Breast Cancer Models

Aanei, I. L., ElSohly, A. M., Farkas, M. E., Netirojjanakul, C., Regan, M., Murphy, S. T., O’Neil, J. P., Seo, Y., & Francis, M. B. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00566 · Cited by 59 · see citing works

Modular interior loading and exterior decoration of a virus-like particle

Sharma, J., Uchida, M., Miettinen, H. M., et al. (2017) · Nanoscale · doi:10.1039/c7nr03018e · Cited by 59 · see citing works

Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents

Lee, H., Shahrivarkevishahi, A., Lumata, J. L., Luzuriaga, M. A., Hagge, L. M., Benjamin, C., Brohlin, O. R., Parish, C. R., Firouzi, H. R., Nielsen, S. O., et al. (2020) · Chemical Science · doi:10.1039/c9sc05510j · Cited by 58 · see citing works

The Antibiotic Resistance Crisis

Joseph, H. (2021) · Cited by 57 · see citing works

Chemically Modifying Viruses for Diverse Applications

Mohan, K., & Weiss, G. A. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00060 · Cited by 57 · see citing works

Physalis Mottle Virus-like Nanoparticles for Targeted Cancer Imaging

Hu, H., Hema, M., Gu, Y., Zhang, Y., Yu, X., & Steinmetz, N. F. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b03956 · Cited by 57 · see citing works

Targeting Mutated Plus Germline Epitopes Confers Pre-clinical Efficacy of an Instantly Formulated Cancer Nano-Vaccine

Mohsen, M. O., Vogel, M., Riether, C., Müller, J., Salatino, S., Ternette, N., Gomes, A. C., Cabral‐Miranda, G., El-Turabi, A., Ruedl, C., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01015 · Cited by 56 · see citing works

Engineered M13 Bacteriophage Nanocarriers for Intracellular Delivery of Exogenous Proteins to Human Prostate Cancer Cells

DePorter, S. M., & McNaughton, B. R. (2014) · Bioconjugate Chemistry · doi:10.1021/bc500339k · Cited by 53 · see citing works

Dual Functionalized Bacteriophage Qβ as a Photocaged Drug Carrier

Chen, Z., Li, N., Chen, L., et al. (2016) · Small · doi:10.1002/smll.201601053 · Cited by 53 · see citing works

Delivery of mitoxantrone using a plant virus-based nanoparticle for the treatment of glioblastomas

Lam, P., Lin, R. D., & Steinmetz, N. F. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01191e · Cited by 53 · see citing works

Programmable In Vitro Coencapsidation of Guest Proteins for Intracellular Delivery by Virus-like Particles

Dashti, N. H., Abidin, R. S., & Sainsbury, F. (2018) · ACS Nano · doi:10.1021/acsnano.8b01059 · Cited by 52 · see citing works

Antitumor Humoral and T Cell Responses by Mucin-1 Conjugates of Bacteriophage Qβ in Wild-type Mice

Yin, Z., Wu, X., Kaczanowska, K., et al. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00313 · Cited by 52 · see citing works

Multifunctional Enzyme Packaging and Catalysis in the Qβ Protein Nanoparticle

Fiedler, J. D., Fishman, M. R., Brown, S. D., et al. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00885 · Cited by 52 · see citing works

Presentation and Delivery of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand via Elongated Plant Viral Nanoparticle Enhances Antitumor Efficacy

Le, D. H. T., Commandeur, U., & Steinmetz, N. F. (2019) · ACS Nano · doi:10.1021/acsnano.8b09462 · Cited by 51 · see citing works

Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice

Li, Q., Cao, C., Chackerian, B., Schiller, J. T., Gordon, M. N., Ugen, K. E., & Morgan, D. (2004) · BMC Neuroscience · doi:10.1186/1471-2202-5-21 · Cited by 50 · see citing works

Implementation of P22 Viral Capsids As Intravascular Magnetic Resonance T1 Contrast Conjugates via Site-Selective Attachment of Gd(III)-Chelating Agents

Min, J., Jung, H., Shin, H., Cho, G., Cho, H., & Kang, S. (2013) · Biomacromolecules · doi:10.1021/bm400461j · Cited by 50 · see citing works

A Modular Vaccine Development Platform Based on Sortase-Mediated Site-Specific Tagging of Antigens onto Virus-Like Particles

Tang, S., Xuan, B., Ye, X., et al. (2016) · Scientific Reports · doi:10.1038/srep25741 · Cited by 50 · see citing works

Update knowledge on cervical cancer incidence and prevalence in Asia

Daniyal, M., Akhtar, N., Ahmad, S., et al. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.9.3617 · Cited by 48 · see citing works

Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy

Maphis, N. M., Peabody, J., Crossey, E., Jiang, S., Ahmad, F. A. J., Álvarez, M. J., Mansoor, S. K., Yaney, A., Yang, Y., Sillerud, L. O., et al. (2019) · npj Vaccines · doi:10.1038/s41541-019-0118-4 · Cited by 48 · see citing works

Polydopamine-decorated tobacco mosaic virus for photoacoustic/magnetic resonance bimodal imaging and photothermal cancer therapy

Hu, H., Yang, Q., Baroni, S., et al. (2019) · Nanoscale · doi:10.1039/c9nr02065a · Cited by 46 · see citing works

Polymorphic assembly of virus-capsid proteins around DNA and the cellular uptake of the resulting particles

de Ruiter, M. V., van der Hee, R. M., Driessen, A. J. M., Keurhorst, E. D., Hamid, M., & Cornelissen, J. J. L. M. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.06.019 · Cited by 46 · see citing works

Viral nanoparticle-encapsidated enzyme and restructured DNA for cell delivery and gene expression

Liu, J. L., Dixit, A. B., Robertson, K. L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321940111 · Cited by 45 · see citing works

Biomaterial-based nanoreactors, an alternative for enzyme delivery

Koyani, R. D., Pérez‐Robles, J., Cadena-Nava, R. D., & Vázquez-Duhalt, R. (2017) · Nanotechnology Reviews · doi:10.1515/ntrev-2016-0071 · Cited by 45 · see citing works

Anti-IL-17 monoclonal antibodies for the treatment of ankylosing spondylitis

Wendling, D., Verhoeven, F., & Prati, C. (2018) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2019.1554053 · Cited by 45 · see citing works

IL-1 and atherosclerosis: a murine twist to an evolving human story

Rader, D. J. (2011) · Journal of Clinical Investigation · doi:10.1172/jci61163 · Cited by 44 · see citing works

Site-Selective Nucleation and Size Control of Gold Nanoparticle Photothermal Antennae on the Pore Structures of a Virus

Benjamin, C., Chen, Z., Kang, P., Wilson, B. A., Li, N., Nielsen, S. O., Qin, Z., & Gassensmith, J. J. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b10446 · Cited by 44 · see citing works

Vaccination with Aβ-Displaying Virus-Like Particles Reduces Soluble and Insoluble Cerebral Aβ and Lowers Plaque Burden in APP Transgenic Mice

Bach, P., Tschäpe, J., Kopietz, F., Braun, G., Baade, J. K., Wiederhold, K., Staufenbiel, M., Prinz, M., Deller, T., Kalinke, U., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803366 · Cited by 43 · see citing works

Glyco-decorated tobacco mosaic virus as a vector for cisplatin delivery

Liu, X., Liu, B., Gao, S., Wang, Z., Tian, Y., Wu, M., Jiang, S., & Niu, Z. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00100b · Cited by 43 · see citing works

Bioengineering fluorescent virus-like particle/RNAi nanocomplexes act synergistically with temozolomide to eradicate brain tumors

Pang, H., Huang, C.-Y., Chou, Y.-W., Lin, C.-J., Zhou, Z.-L., Shiue, Y., Wei, K., & Yang, H. (2019) · Nanoscale · doi:10.1039/c9nr01247h · Cited by 43 · see citing works

Chimeric Virus-Like Particles Made Using GAG and M1 Capsid Proteins Providing Dual Drug Delivery and Vaccination Platform

Deo, V. K., Kato, T., & Park, E. Y. (2015) · Molecular Pharmaceutics · doi:10.1021/mp500860x · Cited by 40 · see citing works

Construction of Multifunctional Fe3O4-MTX@HBc Nanoparticles for MR Imaging and Photothermal Therapy/Chemotherapy

Zhang, Q., Shan, W., Ai, C., et al. (2017) · Nanotheranostics · doi:10.7150/ntno.21942 · Cited by 40 · see citing works

Delivery of thrombolytic therapy using rod-shaped plant viral nanoparticles decreases the risk of hemorrhage

Pitek, A. S., Park, J., Wang, Y., et al. (2018) · Nanoscale · doi:10.1039/c8nr02861c · Cited by 40 · see citing works

Imaging of Lymph Node Micrometastases Using an Oncolytic Herpes Virus and [18F]FEAU PET

Brader, P., Kelly, K. J., Sheng, G., Shah, J. P., Wong, R. J., Hricak, H., Blasberg, R. G., Fong, Y., & Gil, Z. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004789 · Cited by 39 · see citing works

Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qβ, and the Induction of Anticancer Antibodies

Yin, Z., Dulaney, S. B., McKay, C. S., et al. (2015) · ChemBioChem · doi:10.1002/cbic.201500499 · Cited by 39 · see citing works

Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia

Ji, M., Xie, X.-X., Liu, D., Yu, X., Zhang, Y., Zhang, L. L., Wang, S., Huang, Y., & Liu, R. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0378-7 · Cited by 38 · see citing works

A Viral Nanoparticle Cancer Vaccine Delays Tumor Progression and Prolongs Survival in a HER2+ Tumor Mouse Model

Shukla, S., Jandzinski, M., Wang, C., Gong, X., Bonk, K. W., Keri, R. A., & Steinmetz, N. F. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201800139 · Cited by 38 · see citing works

Gold-coated plant virus as computed tomography imaging contrast agent

Aljabali, A. A. A., Zoubi, M. S. A., Al‐Batayneh, K., et al. (2019) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.10.195 · Cited by 38 · see citing works

Speciation of Phenanthriplatin and Its Analogs in the Core of Tobacco Mosaic Virus

Vernekar, A. A., Berger, G., Czapar, A. E., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b12697 · Cited by 36 · see citing works

Intrastructural Help: Harnessing T Helper Cells Induced by Licensed Vaccines for Improvement of HIV Env Antibody Responses to Virus-Like Particle Vaccines

Elsayed, H., Nabi, G., McKinstry, W. J., et al. (2018) · Journal of Virology · doi:10.1128/jvi.00141-18 · Cited by 36 · see citing works

Author Correction: Density functional theory study of the role of benzylic hydrogen atoms in the antioxidant properties of lignans

Vo, Q. V., Nam, P. C., Bay, M. V., Thong, N. M., Cuong, N. D., & Mechler, Á. (2019) · Scientific Reports · doi:10.1038/s41598-019-40317-y · Cited by 36 · see citing works

Production of Immunoabsorbent Nanoparticles by Displaying Single‐Domain Protein A on Potato Virus X

Uhde‐Holzem, K., McBurney, M., Tiu, B. D. B., et al. (2015) · Macromolecular Bioscience · doi:10.1002/mabi.201500280 · Cited by 34 · see citing works

Trackable and Targeted Phage as Positron Emission Tomography (PET) Agent for Cancer Imaging

Li, Z., Jin, Q., Huang, C., Dasa, S. S. K., Chen, L., Yap, L.-P., Liu, S., Cai, H., Park, R., & Conti, P. S. (2011) · Theranostics · doi:10.7150/thno/v01p0371 · Cited by 34 · see citing works

Cargo-Compatible Encapsulation in Virus-Based Nanoparticles

Li, L., Xu, C., Zhang, W., Secundo, F., Li, C., Zhang, Z., Zhang, X., & Li, F. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00679 · Cited by 34 · see citing works

Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challenges

Taha, E. A., Lee, J., & Hotta, A. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.013 · Cited by 259 · see citing works

Immune responses to gene editing by viral and non-viral delivery vectors used in retinal gene therapy

Ren, D., Fisson, S., Dalkara, D., & Ail, D. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091973 · Cited by 52 · see citing works

[Research advances on the application of biocompatible materials in treating diabetic wounds].

Liu, K. T., & Hu, D. (2021) · PubMed · doi:10.3760/cma.j.cn501120-20200619-00316

Image-Guided Cancer Nanomedicine

Kim, D. (2018) · Journal of Imaging · doi:10.3390/jimaging4010018 · Cited by 32 · see citing works

Cancer nanomedicine: is targeting our target?

Lammers, T., Kiessling, F. M., Ashford, M. B., Hennink, W. E., Crommelin, D. J. A., & Storm, G. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.69 · Cited by 232 · see citing works

NANOMEDICINE—PRESENT AND FUTURE OF DISEASE MANAGEMENT

Mehamalini, V. (2022) · INTERNATIONAL JOURNAL OF NANOBIOTECHNOLOGY · doi:10.37628/ijn.v8i1.892

Nanomedicine: Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines (Adv. Healthcare Mater. 1/2018)

Balasubramanian, V., Liu, Z., Hirvonen, J. J., et al. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201870005 · Cited by 7 · see citing works