The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Laser-Activatable CuS Nanodots to Treat Multidrug-Resistant Bacteria and Release Copper Ion to Accelerate Healing of Infected Chronic Nonhealing Wounds
Open accessAbstract
Abstract Chronic nonhealing wounds have imposed serious challenges in the clinical practice, especially for the patients infected with multidrug-resistant microbes. Herein, we developed an ultrasmall copper sulfide (covellite) nanodots (CuS NDs) based dual functional nanosystem to cure multidrug-resistant bacteria-infected chronic nonhealing wound. The nanosystem could eradicate multidrug-resistant bacteria and expedite wound healing simultaneously owing to the photothermal effect and remote control of copper-ion release. The antibacterial results indicated that the combination treatment of photothermal CuS NDs with photothermal effect initiated a strong antibacterial effect for drug-resistant pathogens including methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum β-lactamase Escherichia coli both in vitro and in vivo. Meanwhile, the released Cu2+ could promote fibroblast cell migration and endothelial cell angiogenesis, thus accelerating wound-healing effects. In MRSA-infected diabetic mice model, the nanosystem exhibited synergistic wound healing effect of infectious wounds in vivo and demonstrated negligible toxicity and nonspecific damage to major organs. The combination of ultrasmall CuS NDs with photothermal therapy displayed enhanced therapeutic efficacy for chronic nonhealing wound in multidrug-resistant bacterial infections, which may represent a promising class of antibacterial strategy for clinical translation.
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Cites
Toxic potential of materials at the nanolevel
Nel, A., Xia, T., Mädler, L., & Li, N. (2006) · Science · doi:10.1126/science.1114397 · Cited by 9,324
Factors affecting wound healing
Guo, S., & DiPietro, L. A. (2010) · Journal of Dental Research · doi:10.1177/0022034509359125 · Cited by 5,792
The neglected role of copper ions in wound healing
Kornblatt, A. P., Nicoletti, V. G., & Travaglia, A. (2016) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2016.02.012 · Cited by 221
Cited by
Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections
Huo, J., Jia, Q., Huang, H., Zhang, J., Li, P., Dong, X., & Huang, W. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00074h · Cited by 847
Inorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
Antimicrobial Nano-Agents: The Copper Age
Ermini, M. L., & Voliani, V. (2021) · ACS Nano · doi:10.1021/acsnano.0c10756 · Cited by 477
2D MOF Periodontitis Photodynamic Ion Therapy
Li, J., Song, S., Meng, J., Tan, L., Liu, X., Zheng, Y., Li, Z., Yeung, K. W. K., Cui, Z., Liang, Y., et al. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c07875 · Cited by 316
Yuan, Z., Tao, B., He, Y., Mu, C., Liu, G., Zhang, J., Liao, Q., Liu, P., & Cai, K. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119479 · Cited by 286
Metadata
- Authors
- Qiao, Y., Ping, Y., Zhang, H., Zhou, B., Liu, F., Yu, Y., Xie, T., Li, W., Zhong, D., Zhang, Y., Yao, K., Santos, H. A., & Zhou, M.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-01-03
- Volume
- 11
- Issue
- 4
- Pages
- 3809-3822
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2906764158
- Cited by
- 226
- References
- 3
- FWCI
- 17.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
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