Indocyanine Green J Aggregates in Polymersomes for Near-Infrared Photoacoustic Imaging
Abstract
Clinical translation of photoacoustic imaging (PAI) has been limited by the lack of near-infrared (NIR) contrast agents with low toxicity required for regulatory approval. Herein, J aggregates of indocyanine green (ICG) with strong NIR absorbance were encapsulated at high loadings within small 77 nm polymersomes (nanocapsules) composed of poly(lactide- co -glycolide- b -poly(ethylene glycol)) (PLGA- b -PEG) bilayers, thus enabling PAI of of breast and ovarian cancer cells with high specificity and a sensitivity at the level of ∼100 total cells. All of the major components of the polymersomes are FDA approved and used in the clinic. During formation of polymersomes with a water-in-oil-in-water double emulsion process, loss of ICG from the ICG J aggregates was minimized by coating them with a layer of branched polyethylenimine and by providing excess “sacrificial” ICG to adsorb at the oil–water interfaces. The encapsulated J aggregates were protected against dissociation by the polymersome shell for 24 h in 100% fetal bovine serum, after which the polymersomes biodegraded and the J aggregates dissociated to ICG monomers.
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Once the ICG aggregates are internalized into cells, they disassociate into free ICG.
“Once the aggregates are internalized into cells, they disassociate into free ICG.120”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [120]
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Polymersomes: Tough Vesicles Made from Diblock Copolymers
Discher, B. M., Won, Y., Ege, D. S., Lee, J. C., Bates, F. S., Discher, D. E., & Hammer, D. A. (1999) · Science · doi:10.1126/science.284.5417.1143 · Cited by 2,513 · see citing works
Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging
Zhang, H. F., Maslov, K., Stoica, G., & Wang, L. V. (2006) · Nature Biotechnology · doi:10.1038/nbt1220 · Cited by 1,855 · see citing works
Khlebtsov, N. G., & Dykman, L. A. (2010) · Chemical Society Reviews · doi:10.1039/c0cs00018c · Cited by 1,587 · see citing works
Blanazs, A., Armes, S. P., & Ryan, A. J. (2009) · Macromolecular Rapid Communications · doi:10.1002/marc.200800713 · Cited by 1,500 · see citing works
Contrast agents for molecular photoacoustic imaging
Weber, J., Beard, P. C., & Bohndiek, S. E. (2016) · Nature Methods · doi:10.1038/nmeth.3929 · Cited by 1,276 · see citing works
On the origins of morphological complexity in block copolymer surfactants
Jain, S., & Bates, F. S. (2003) · Science · doi:10.1126/science.1082193 · Cited by 1,217 · see citing works
Cheng, L., Liu, J., Gu, X., Gong, H., Shi, X., Liu, T., Wang, C., Wang, X., Liu, G., Xing, H., et al. (2013) · Advanced Materials · doi:10.1002/adma.201304497 · Cited by 1,109 · see citing works
Light-absorbing properties, stability, and spectral stabilization of indocyanine green
Landsman, M. L. J., Kwant, G., Mook, G. A., & Zijlstra, W. G. (1976) · Journal of Applied Physiology · doi:10.1152/jappl.1976.40.4.575 · Cited by 837 · see citing works
Fluorescence Properties and Metabolic Features of Indocyanine Green (ICG) as Related to Angiography
Desmettre, T. J., Devoisselle, J., & Mordon, S. R. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00123-5 · Cited by 762 · see citing works
Sheng, Z., Hu, D., Zheng, M., Zhao, P., Liu, H., Gao, D., Gong, P., Gao, G., Zhang, P., Ma, Y., et al. (2014) · ACS Nano · doi:10.1021/nn5062386 · Cited by 719 · see citing works
Giant Wormlike Rubber Micelles
Won, Y., DAVIS, H. T., & Bates, F. S. (1999) · Science · doi:10.1126/science.283.5404.960 · Cited by 667 · see citing works
Degradation of poly(lactic-co-glycolic acid) microspheres: Effect of copolymer composition
Park, T. G. (1995) · Biomaterials · doi:10.1016/0142-9612(95)93575-x · Cited by 642 · see citing works
Muthu, M. S., Leong, D. T., Mei, L., & Feng, S. (2014) · Theranostics · doi:10.7150/thno.8698 · Cited by 609 · see citing works
Subik, K., Lee, J.-F., Baxter, L., Strzepek, T., Costello, D., Crowley, P., Xing, L., Hung, M., Bonfiglio, T. A., Hicks, D. G., et al. (2010) · Breast Cancer Basic and Clinical Research · doi:10.1177/117822341000400004 · Cited by 576 · see citing works
Xu, Q., Ensign, L. M., Boylan, N. J., Schön, A., Gong, X., Yang, J.-C., Lamb, N. W., Cai, S., Yu, T., Freire, E., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b03876 · Cited by 568 · see citing works
Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines
Zhang, Y., Jeon, M., Rich, L. J., Hong, H., Geng, J., Zhang, Y., Shi, S., Barnhart, T. E., Alexandridis, P., Huizinga, J. D., et al. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2014.130 · Cited by 443 · see citing works
Kumar, S., Aaron, J., & Sokolov, K. (2008) · Nature Protocols · doi:10.1038/nprot.2008.1 · Cited by 412 · see citing works
Self-citationUltrahigh Sensitivity Carbon Nanotube Agents for Photoacoustic Molecular Imaging in Living Mice
de la Zerda, A., Liu, Z., Bodapati, S., Teed, R., Vaithilingam, S., Khuri-Yakub, B. T., Chen, X. S., Dai, H., & Gambhir, S. S. (2010) · Nano Letters · doi:10.1021/nl100890d · Cited by 396 · see citing works
Near-infrared-emissive polymersomes: Self-assembled soft matter for in vivo optical imaging
Ghoroghchian, P. P., Frail, P. R., Susumu, K., Blessington, D. M., Brannan, A. K., Bates, F. S., Chance, B., Hammer, D. A., & Therien, M. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409394102 · Cited by 369 · see citing works
Won, Y., Brannan, A. K., DAVIS, H. T., & Bates, F. S. (2002) · The Journal of Physical Chemistry B · doi:10.1021/jp013639d · Cited by 340 · see citing works
Yu, J. Z., Javier, D. J., Yaseen, M. A., Nitin, N., Richards-Kortum, R. R., Anvari, B., & Wong, M. S. (2010) · Journal of the American Chemical Society · doi:10.1021/ja908139y · Cited by 310 · see citing works
Lee, C., Cheng, S., Wang, Y., Chen, Y., Chen, N., Souris, J. S., Chen, C., Mou, C., Yang, C., & Lo, L. (2008) · Advanced Functional Materials · doi:10.1002/adfm.200800753 · Cited by 301 · see citing works
Tissue-mimicking phantoms for photoacoustic and ultrasonic imaging
Cook, J. R., Bouchard, R. R., & Emelianov, S. (2011) · Biomedical Optics Express · doi:10.1364/boe.2.003193 · Cited by 287 · see citing works
Self-citationMultispectral Optoacoustic Tomography (MSOT) of Human Breast Cancer
Diot, G., Metz, S., Noske, A., Liapis, E., Schroeder, B., Ovsepian, S. V., Meier, R., Rummeny, E. J., & Ntziachristos, V. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-3200 · Cited by 272 · see citing works
Indocyanine Green: Physicochemical Factors Affecting Its Fluorescencein Vivo
Mordon, S., Devoisselle, J. M., Soulie-Begu, S., & Desmettre, T. (1998) · Microvascular Research · doi:10.1006/mvre.1998.2068 · Cited by 268 · see citing works
Saxena, V. K., Sadoqi, M., & Shao, J. (2004) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2004.01.002 · Cited by 265 · see citing works
Yan, F., Wu, H., Liu, H., Deng, Z., Liu, H., Duan, W., Liu, X., & Zheng, H. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.050 · Cited by 254 · see citing works
Indocyanine Green Nanoparticles for Theranostic Applications
Sheng, Z., Hu, D., Xue, M., He, M., Gong, P., & Cai, L. (2013) · Nano-Micro Letters · doi:10.1007/bf03353743 · Cited by 251 · see citing works
Vila, A., Gill, H., McCallion, O. N. M., & Alonso, M. J. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.04.026 · Cited by 249 · see citing works
Binding properties of indocyanine green in human blood.
Yoneya, S., Saito, T., Komatsu, Y., Koyama, I., Takahashi, K., & Duvoll-Young, J. (1998) · PubMed · Cited by 246 · see citing works
In vitro degradation of a novel poly(lactide-co-glycolide) 75/25 foam
Holy, C. E., Dang, S. M., Davies, J. E., & Shoichet, M. S. (1999) · Biomaterials · doi:10.1016/s0142-9612(98)00256-7 · Cited by 241 · see citing works
Polyelectrolyte-mediated surface interactions
Claesson, P. M., Poptoshev, E., Blomberg, E., & Dédinaité, A. (2005) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2004.09.008 · Cited by 206 · see citing works
Bézière, N., Lozano, N., Nunes, A., Salichs, J., Queirós, D., Kostarelos, K., & Ntziachristos, V. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.014 · Cited by 191 · see citing works
Molecular specific optoacoustic imaging with plasmonic nanoparticles
Mallidi, S., Larson, T. A., Aaron, J., Sokolov, K., & Emelianov, S. (2007) · Optics Express · doi:10.1364/oe.15.006583 · Cited by 186 · see citing works
Self-citationEffect of Bilayer Thickness on Membrane Bending Rigidity
Bermudez, H., Hammer, D. A., & Discher, D. E. (2003) · Langmuir · doi:10.1021/la035497f · Cited by 186 · see citing works
Deep reflection-mode photoacoustic imaging of biological tissue
Song, K. H., & Wang, L. V. (2007) · Journal of Biomedical Optics · doi:10.1117/1.2818045 · Cited by 181 · see citing works
Hayward, R. C., Utada, A. S., Dan, N. R., & Weitz, D. A. (2006) · Langmuir · doi:10.1021/la060094b · Cited by 180 · see citing works
Enzymatic degradation behavior and mechanism of Poly(lactide-co-glycolide) foams by trypsin
Cai, Q. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00377-0 · Cited by 161 · see citing works
Anticancer activity of cisplatin-loaded PLGA-mPEG nanoparticles on LNCaP prostate cancer cells
Gryparis, E. C., Hatziapostolou, M., Papadimitriou, Ε., & Avgoustakis, K. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2006.12.017 · Cited by 139 · see citing works
Engineering Polymersomes for Diagnostics and Therapy
Leong, J., Teo, J. Y., Aakalu, V. K., Yang, Y. Y., & Kong, H. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701276 · Cited by 139 · see citing works
Dowling, D. J., Scott, E. A., Scheid, A., Bergelson, I., Joshi, S., Pietrasanta, C., Brightman, S. E., Sánchez‐Schmitz, G., van Haren, S. D., Ninković, J., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.12.985 · Cited by 138 · see citing works
Enzymatic degradation of polylactide stereocopolymers with predominant d-lactyl contents
Li, S., Girard, A., Garreau, H., & Vert, M. (2000) · Polymer Degradation and Stability · doi:10.1016/s0141-3910(00)00152-x · Cited by 137 · see citing works
Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus
Xu, Q., Boylan, N. J., Cai, S., Miao, B., Patel, H., & Hanes, J. S. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.05.035 · Cited by 122 · see citing works
Luke, G. P., Myers, J. N., Emelianov, S., & Sokolov, K. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0796 · Cited by 116 · see citing works
Self-citationNano-sized Indocyanine Green J-aggregate as a One-component Theranostic Agent
Liu, R., Tang, J., Xu, Y., Zhou, Y., & Dai, Z. (2017) · Nanotheranostics · doi:10.7150/ntno.19935 · Cited by 116 · see citing works
Gholibegloo, E., Karbasi, A., Pourhajibagher, M., Chiniforush, N., Ramazani, A., Akbari, T., Bahador, A., & Khoobi, M. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.02.004 · Cited by 106 · see citing works
Ultrasound-guided photoacoustic imaging: current state and future development
Bouchard, R. R., Sahin, O., & Emelianov, S. (2014) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2014.2930 · Cited by 105 · see citing works
Self-citationWang, T., Petrenko, V. A., & Torchilin, V. P. (2010) · Molecular Pharmaceutics · doi:10.1021/mp1001125 · Cited by 100 · see citing works
J-aggregation and disaggregation of indocyanine green in water
Rotermund, F., Weigand, R., & Penzkofer, А. (1997) · Chemical Physics · doi:10.1016/s0301-0104(97)00151-1 · Cited by 94 · see citing works
Dewetting-Induced Membrane Formation by Adhesion of Amphiphile-Laden Interfaces
Shum, H. C., Carreras, E. S., Kim, J., Ehrlicher, A. J., Bibette, J., & Weitz, D. A. (2011) · Journal of the American Chemical Society · doi:10.1021/ja108673h · Cited by 94 · see citing works
Shakiba, M., Ng, K. K., Huynh, E., Chan, H. H. L., Charron, D. M., Chen, J., Muhanna, N., Foster, F. S., Wilson, B. C., & Zheng, G. (2015) · Nanoscale · doi:10.1039/c5nr08165c · Cited by 90 · see citing works
Self-Assembled Polymersomes Conjugated with Lactoferrin as Novel Drug Carrier for Brain Delivery
Yu, Y., Pang, Z., Lü, W., Yin, Q., Gao, H., & Jiang, X. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0513-7 · Cited by 86 · see citing works
From Stealthy Polymersomes and Filomicelles to “Self” Peptide-Nanoparticles for Cancer Therapy
Oltra, N. S., Nair, P. R., & Discher, D. E. (2014) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-060713-040447 · Cited by 84 · see citing works
Molecular photoacoustic imaging with ultra-small gold nanoparticles
Han, S., Bouchard, R. R., & Sokolov, K. (2019) · Biomedical Optics Express · doi:10.1364/boe.10.003472 · Cited by 72 · see citing works
Self-citationNonlinear photoacoustic signal increase from endocytosis of gold nanoparticles
Nam, S. Y., Ricles, L. M., Suggs, L. J., & Emelianov, S. (2012) · Optics Letters · doi:10.1364/ol.37.004708 · Cited by 68 · see citing works
Gu, W., Zhang, Q., Zhang, T., Li, Y., Xiang, J., Peng, R., & Liu, J. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01619c · Cited by 60 · see citing works
Chemical Toxicity of Indocyanine Green Damages Retinal Pigment Epithelium
Ikagawa, H., Yoneda, M., Iwaki, M., Isogai, Z., Tsujii, K., Yamazaki, R., Kamiya, T., & Zako, M. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1521 · Cited by 59 · see citing works
Indocyanine green binds to DOTAP liposomes for enhanced optical properties and tumor photoablation
Miranda, D., Wan, C., Kilian, H. I., Mabrouk, M. T., Zhou, Y., Jin, H., & Lovell, J. F. (2019) · Biomaterials Science · doi:10.1039/c9bm00551j · Cited by 50 · see citing works
Ashjari, M., Khoee, S., & Mahdavian, A. R. (2012) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2012.05.035 · Cited by 48 · see citing works
Miranda, D., Huang, H., Kang, H., Zhan, Y., Wang, D., Zhou, Y., Geng, J., Kilian, H. I., Stiles, W., Razi, A., et al. (2019) · Theranostics · doi:10.7150/thno.28376 · Cited by 48 · see citing works
Microstructure of indocyanine green J-aggregates in aqueous solution
Zweck, J., & Penzkofer, А. (2001) · Chemical Physics · doi:10.1016/s0301-0104(01)00368-8 · Cited by 41 · see citing works
Biology of the Epidermal Growth Factor Receptor Family
Barnes, C. J., & Kumar, R. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-7847-1_1 · Cited by 37 · see citing works
Adsorption of Polyethylenimine on Graphite: An Atomic Force Microscopy Study
Schneider, M., Brinkmann, M., & Möhwald, H. (2003) · Macromolecules · doi:10.1021/ma0345293 · Cited by 33 · see citing works
Multipronged Biomimetic Approach To Create Optically Tunable Nanoparticles
Harmatys, K. M., Chen, J., Charron, D. M., MacLaughlin, C. M., & Zheng, G. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201803535 · Cited by 33 · see citing works
Gottschalk, N., Kimmig, R., Lang, S., Singh, M., & Brandau, S. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130912000 · Cited by 29 · see citing works
Lu, H. D., Lim, T. L., Javitt, S., Heinmiller, A., & Prud’homme, R. K. (2017) · ACS Combinatorial Science · doi:10.1021/acscombsci.7b00031 · Cited by 29 · see citing works
The Effect of Stabilizer on the Mechanical Response of Double‐Emulsion‐Templated Polymersomes
Jang, W., Park, S. C., Kim, M., Doh, J., Lee, D., & Hammer, D. A. (2014) · Macromolecular Rapid Communications · doi:10.1002/marc.201400472 · Cited by 19 · see citing works
Quasicrystals and quasicrystal-related phases in the AlMn system
Bendersky, L. A. (1988) · Materials Science and Engineering · doi:10.1016/0025-5416(88)90351-5 · Cited by 18 · see citing works
Wolfe, J. D., & Csaky, K. G. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2004.05.018 · Cited by 13 · see citing works
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Alsaab, H. O., Alharbi, F., Al-Hibs, A. S., Alanazi, N. B., Alshehri, B. Y., Saleh, M. A., Alshehri, F. S., Algarni, M. A., Almugaiteeb, T., Uddin, M. N., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122728 · Cited by 296 · see citing works
Aza-BODIPY-Based Nanomedicines in Cancer Phototheranostics
Chen, D., Zhong, Z., Ma, Q., Shao, J., Huang, W., & Dong, X. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c05021 · Cited by 172 · see citing works
Recent progress in utilizing near-infrared J-aggregates for imaging and cancer therapy
Xu, S., Liu, H., Huan, S., Yuan, L., & Zhang, X. (2020) · Materials Chemistry Frontiers · doi:10.1039/d0qm00557f · Cited by 133 · see citing works
Ma, X., Huang, Y., Chen, W., Liu, J., Liu, S. H., Yin, J., & Yang, G. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202216109 · Cited by 88 · see citing works
Wu, M., Mei, T., Lin, C., Wang, Y., Chen, J., Le, W., Sun, M., Xu, J., Dai, H., Zhang, Y., et al. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b23177 · Cited by 81 · see citing works
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Razansky, D., Klohs, J., & Ni, R. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05207-4 · Cited by 77 · see citing works
Sridharan, B., & Lim, H. G. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02192-8 · Cited by 62 · see citing works
Zhou, Y., Chang, C., Liu, Z., Zhao, Q., Xu, Q., Li, C., Chen, Y., Zhang, Y., & Lü, B. (2021) · Langmuir · doi:10.1021/acs.langmuir.0c03250 · Cited by 60 · see citing works
Tian, Y., Yin, D., & Yan, L. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1831 · Cited by 54 · see citing works
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Li, Z., Liang, P., Ren, T., Yuan, L., & Zhang, X. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202305742 · Cited by 54 · see citing works
Size-tunable ICG-based contrast agent platform for targeted near-infrared photoacoustic imaging.
Singh, S., Giammanco, G., Hu, C.-H., Bush, J., Cordova, L. S., Lawrence, D. J., Moran, J. L., Chitnis, P. V., & Veneziano, R. (2022) · Photoacoustics · doi:10.1016/j.pacs.2022.100437 · Cited by 52 · see citing works
Zhao, S., Huang, P., Zhang, H., Rich, J. T., Bachman, H., Ye, J., Zhang, W., Chen, C., Xie, Z., Tian, Z., et al. (2021) · Lab on a Chip · doi:10.1039/d1lc00265a · Cited by 51 · see citing works
Millard, M., Bernhard, Y., Canilho, N., Grandemange, S., Parant, S., Mourer, M., Lassalle, H., & Pasc, A. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113516 · Cited by 42 · see citing works
Piwoński, H., Nozue, S., & Habuchi, S. (2022) · ACS Nanoscience Au · doi:10.1021/acsnanoscienceau.1c00038 · Cited by 39 · see citing works
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Beygi, M., Oroojalian, F., Hosseini, S. S., Mokhtarzadeh, A., Kesharwani, P., & Sahebkar, A. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101209 · Cited by 32 · see citing works
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Zhou, X., Lin, S., & Yan, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01449-y · Cited by 29 · see citing works
Kawelah, M. R., Han, S., Dinçer, C. A., Jeon, J., Brisola, J., Hussain, A. F., Jeevarathinam, A. S., Bouchard, R. R., Marras, A. E., Truskett, T. M., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c16584 · Cited by 27 · see citing works
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Салимовна, Ф. Д., Maklygina, Y., Romanishkin, I. D., Yakovlev, D. V., Plyutinskaya, A. D., Bezdetnaya, L., & Loschenov, V. B. (2021) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2021.102636 · Cited by 23 · see citing works
Polymer Vesicles and Lipid Nanoparticles
Luo, Y., Cook, A. B., Abdelmohsen, L. K. E. A., & van Hest, J. C. M. (2024) · Annual Review of Materials Research · doi:10.1146/annurev-matsci-080222-105636 · Cited by 22 · see citing works
Recent Advances in Nanomaterials for Neural Applications: Opportunities and Challenges
Sisubalan, N., Shalini, R., Ramya, S., Sivamaruthi, B. S., & Chaiyasut, C. (2023) · Nanomedicine · doi:10.2217/nnm-2023-0261 · Cited by 21 · see citing works
Picchio, M. L., Bergueiro, J., Wedepohl, S., Minari, R. J., Igarzabal, C. I. Á., Gugliotta, L. M., Cuggino, J. C., & Calderón, M. (2021) · Nanoscale · doi:10.1039/d0nr09058a · Cited by 21 · see citing works
Gosée, C., Cadiou, C., Moreau, J., Callewaert, M., Kowandy, C., Henoumont, C., Larbanoix, L., Laurent, S., & Chuburu, F. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216523 · Cited by 18 · see citing works
Vincy, A., Bhatia, N., & Vankayala, R. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01135 · Cited by 18 · see citing works
Ma, X., Huang, Y., Chen, W., Liu, J., Liu, S. H., Yin, J., & Yang, G. (2022) · Angewandte Chemie · doi:10.1002/ange.202216109 · Cited by 18 · see citing works
Wen, Y., Wang, J., Zheng, W., Zhu, J., Song, X., Chen, T., Zhang, M., Huang, Z., & Li, J. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.04.072 · Cited by 18 · see citing works
Al-Jamal, W. T., Reboredo, C., Abdi, U., Curci, P., Qadadeh, R., Alotaibi, H., Casettari, L., & Hatahet, T. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124963 · Cited by 15 · see citing works
Liu, Q., Taniguchi, M., Goel, S., & Lindsey, J. S. (2023) · Dyes and Pigments · doi:10.1016/j.dyepig.2023.111914 · Cited by 13 · see citing works
Wang, S., Zhang, R., Li, X., Chen, Y., Zhu, L., Yang, B., Wang, J., Du, Y., Liu, J., Ye, T. T., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c06437 · Cited by 13 · see citing works
A pH/ROS dual-responsive nanoparticle system for tumor targeting combined chemotherapy/phototherapy
Luo, Y., Cong, Y., Liu, J., Huang, L., Cheng, W., Xu, P., Yin, Y., Hong, H., & Xu, W. (2023) · New Journal of Chemistry · doi:10.1039/d2nj05078a · Cited by 12 · see citing works
Saad, M. A., Grimaldo-Garcia, S., Sweeney, A., Mallidi, S., & Hasan, T. G. (2023) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.3c00406 · Cited by 12 · see citing works
Supramolecular dye nanoassemblies for advanced diagnostics and therapies
Ramezani, P., Smedt, S. C. D., & Sauvage, F. (2024) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10652 · Cited by 13 · see citing works
Molecular imaging-guided diagnosis and treatment integration for brain diseases
Yu, D., Liu, M., Ding, Q., Wu, Y., Wang, T., Song, L., Li, X., Qian, K., Cheng, Z., Gu, M., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.123021 · Cited by 12 · see citing works
Xu, J., Evers, K., Lin, Y., Tabish, T. A., Zhang, Q., Chung, R., Ryan, M. P., & Xie, F. (2024) · Materials Today Advances · doi:10.1016/j.mtadv.2024.100555 · Cited by 11 · see citing works
Ran, Y., Hu, J., Chen, Y., Rao, Z., Zhao, J., Xu, Z., & Ming, J. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.02.121 · Cited by 10 · see citing works
Alotaibi, H., Hatahet, T., & Al-Jamal, W. T. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107034 · Cited by 10 · see citing works
Recent Advances for Synthesis and Bioapplications of Polymethine Cyanines
Yang, Z., Sun, Q., Ji, L., Meng, C., Heng, H., & Feng, F. (2025) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.202500109 · Cited by 10 · see citing works
Dong, H., Gao, Y., Huang, X., & Wu, X. (2022) · Journal of Materials Chemistry B · doi:10.1039/d1tb02693c · Cited by 10 · see citing works
Xu, W., Leskinen, J. J., Sahlström, T., Happonen, E., Tarvainen, T., & Lehto, V. (2023) · Photoacoustics · doi:10.1016/j.pacs.2023.100552 · Cited by 10 · see citing works
Emerging Trends of J‐Aggregate Formation within Polymeric Nanoassemblies
Hou, M., & Liu, S. (2022) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202200414 · Cited by 9 · see citing works
Viscosity Effects on Excited‐State Dynamics of Indocyanine Green for Phototheranostic
Liao, K., Pan, Y., Wu, Z., Yao, W., Miao, X., Lü, X., Fan, Q., & Hu, W. (2022) · Chemistry - An Asian Journal · doi:10.1002/asia.202200112 · Cited by 9 · see citing works
Stern, N. B., Shrestha, B., & Porter, T. M. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400042 · Cited by 8 · see citing works
Premcheska, S., Lederer, M., Mohanty, S., Alici, A., Skirtach, A. G., & Kaczmarek, A. M. (2024) · Advanced Optical Materials · doi:10.1002/adom.202401026 · Cited by 8 · see citing works
Gamage, R. S., & Smith, B. D. (2022) · Langmuir · doi:10.1021/acs.langmuir.2c01715 · Cited by 8 · see citing works
Repurposing indocyanine green: exploring the potential of an old drug in modern medicine
Sun, X., Peng, Y., He, P., Cheng, H., Li, D., Liu, H., Lin, H., & Liu, G. (2024) · Nanoscale · doi:10.1039/d4nr00283k · Cited by 8 · see citing works
Zan, Y., Liu, J., Zhao, Z., Wei, Y., Yang, N., Zhang, H., Wang, X., & Kang, Y. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c01501 · Cited by 8 · see citing works
Orderly Self‐Assembly of Organic Fluorophores for Sensing and Imaging
Li, Z., Liang, P., Ren, T., Yuan, L., & Zhang, X. (2023) · Angewandte Chemie · doi:10.1002/ange.202305742 · Cited by 7 · see citing works
Xu, P., Kankala, R. K., Wang, S., & Chen, A. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122348 · Cited by 7 · see citing works
Zhao, S., Lee, L., Zhao, Y., Liang, N.-C., & Chen, Y. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1102651 · Cited by 6 · see citing works
Miura, R., Akio, T., Kimura, Y., Akiyoshi, K., & Kondo, T. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.114618 · Cited by 5 · see citing works
Sevieri, M., Paraboschi, I., Gorgoglione, F., Tagliolini, I., Bignami, B., Giacobbo, V., Truffi, M., Bonizzi, A., Corsi, F., & Mazzucchelli, S. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.108006 · Cited by 5 · see citing works
A combined experimental and DFT study of metal core/indocyanine green shell hybrid nanoparticles
Laban, B. B., Novaković, M. M., Anićijević, D. V., Bondžić, A. M., & Vujačić, A. (2023) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2023.123828 · Cited by 5 · see citing works
Vincy, A., Gaikwad, Y., & Vankayala, R. (2024) · Particle & Particle Systems Characterization · doi:10.1002/ppsc.202300233 · Cited by 5 · see citing works
Directional conjugation of monoclonal antibodies to nanoparticles using metal-free click chemistry
Jeevarathinam, A. S., Kawelah, M. R., Han, S., Grindel, B. J., Millward, S. W., Johnston, K. P., & Sokolov, K. (2025) · Nature Protocols · doi:10.1038/s41596-025-01272-3 · Cited by 4 · see citing works
Self-citationSoto-Cruz, J., Mukwaya, V., Naz, M., Zhang, P., López-Brenes, M. J., Sáenz‐Arce, G., Rojas‐Carrillo, O., & Dou, H. (2022) · Langmuir · doi:10.1021/acs.langmuir.2c00937 · Cited by 4 · see citing works
Goel, S., Singh, R., & Tonk, M. (2023) · Current Nanoscience · doi:10.2174/0115734137271094231101062844 · Cited by 4 · see citing works
Linger, C., Maccini, G., Clavier, G. M., Méallet‐Renault, R., Tsapis, N., & Gâteau, J. (2024) · Nanoscale · doi:10.1039/d4nr02880e · Cited by 4 · see citing works
Zhou, J., Feng, Y.-C., Zhao, M.-L., Guo, Q., & Zhao, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1586948 · Cited by 6 · see citing works
Wang, J., Yang, C., Gao, Y., & Wu, X. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb00764b · Cited by 4 · see citing works
Kumar, K., Gurol, M., Sanjarnia, P., Orellano, M. S., Beloqui, A., Ebo, L., Picchio, M. L., & Calderón, M. (2026) · Nano Letters · doi:10.1021/acs.nanolett.6c00338 · Cited by 3 · see citing works
Alotaibi, H., Hatahet, T., & Al-Jamal, W. T. (2025) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2025.114747 · Cited by 3 · see citing works
Beygi, M. H. M., Oroojalian, F., Hosseini, S. S., Mokhtarzadeh, A., Kesharwani, P., & Sahebkar, A. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101190 · Cited by 3 · see citing works
RetractedA multimodal approach to assess a liposomal carrier’s biodistribution, stability, and clearance
Wood, C. A., Jones, C. E., Jeevarathinam, A. S., Watson, R., Han, S., Meyer, J., Sokolov, K., & Bouchard, R. R. (2025) · Photoacoustics · doi:10.1016/j.pacs.2025.100763 · Cited by 2 · see citing works
Self-citationSelf-assembled chromopeptide nanostructures for photothermal therapy of tumors
Liu, J., Zhao, L., Shi, M., Yang, C., Xing, R., & Yan, X. (2026) · Chemical Communications · doi:10.1039/d5cc06380a · Cited by 2 · see citing works
An Indocyanine Green‐Based Nanoprobe for In Vivo Detection of Cellular Senescence
Baker, A., Hartono, M., Ou, H., Bistrović, A., Brown, E. L., Joseph, J. A., Golinska, M. A., González‐Gualda, E., Macías, D., Ge, J., et al. (2024) · Angewandte Chemie · doi:10.1002/ange.202404885 · Cited by 2 · see citing works
Spectral and cytotoxicity studies of hybrid silver nanoparticles in human lymphocytes
Laban, B. B., Ralević, U., Leskovac, A. R., Petrović, S. Ž., Stoiljković, M., Rosić, M., & Nikezić, A. V. (2025) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2025.126360 · Cited by 2 · see citing works
Zhang, Y., Qiu, Z., Лю, Б., & Chen, L. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124558 · Cited by 1 · see citing works
Lipid-stabilized ICG nanoaggregates for the photodisruption of vitreous opacities
Ramezani, P., Félix, J., Ussembayev, Y. Y., Silva, M. H., Lentacker, I., Verbeke, R., Braeckmans, K., Smedt, S. C. D., & Sauvage, F. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102798 · Cited by 1 · see citing works
Dual-Dye Nanoparticle Inks for Multimodal Visualization in Surgical Applications
Gosangi, M., Sant, H. G., Godeshala, S., Singh, V., Chowdhury, T., Ortega, D., Yaron, J. R., Pannala, R., & Rege, K. (2026) · Chemical & Biomedical Imaging · doi:10.1021/cbmi.5c00275 · Cited by 1 · see citing works
Baker, A., Ou, H., Hartono, M., Bistrović, A., Brown, E. L., Joseph, J. A., Golinska, M. A., Sanghera, C., González‐Gualda, E., Macías, D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.12.548691
A Facile Approach to Producing Liposomal J-Aggregates of Indocyanine Green for Photoacoustic ImagingPreprint
Stern, N., Shrestha, B., & Porter, T. M. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4596619
Contrast agent optimization for improved photoacoustic imaging
Bardon, K. M. (2023) · doi:10.17760/d20592710
Spectral and Cytotoxicity Studies of Hybrid Silver Nanoparticles in Human LymphocytesPreprint
Ralević, U., Leskovac, A. R., Petrović, S. Ž., Stoiljković, M., Rosić, M., Nikezić, A. V., & Laban, B. B. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5128892
Chiang, H.-H., Chang, Y.-T., Huang, W.-R., Cai, M.-X., Feng, C., Syu, J.-N., Lai, C., & Chien, Y. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c00769
Torokhov, T., Perkov, S. A., Mokrousov, M. D., Сергеевна, П. Е., Shlykov, M. A., Maksimov, E. G., Sergeev, I. S., Korchagin, S. A., Ershov, E. I., Shcheslavskiy, V. I., et al. (2025) · Laser & Photonics Review · doi:10.1002/lpor.202502094
Photoacoustic imaging at the interface of cellular theranostics
Fox, C. R., Loden, S. A., & Kubelick, K. P. (2026) · Nanomedicine · doi:10.1080/17435889.2026.2615098
Yasunaga, H., Tashiro, Y., & Ando, S. (2026) · Polymer Journal · doi:10.1038/s41428-026-01170-9
Direct Synthesis of Targeted Nanosized ICG J-aggregate for Photoacoustic ImagingPreprint
Singh, S., Cordova, L. S., Such, N., Hanafi, M., Giammanco, G., Lawrence, D. J., Hill, I. E., Chamanara, B., Fenaoui, I., Tarimala, G., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.12.724349
Xu, Y., Hua, Y., Ou, L., Jin, W., Zhang, Y. F., Rao, M., Lin, H., Ji, F., Ding, B., & Shen, Y. (2026) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2026.101489
Aguilera-Garrido, A., Millard, M., Bouché, M., Lemière, P., Canilho, N., Pasc, A., Kataoka, K., Guyse, J. F. R. V., Lassalle, H., & Bernhard, Y. (2026) · Materials Today Advances · doi:10.1016/j.mtadv.2026.100891
Effect of Noscapine Hydrochloride on the Near-Infrared Optical Properties of Indocyanine Green
Bhawana, Borah, A., Goel, T., Brahma, A., Singh, A., Sindhu, J., Chandra, R., & Singh, S. (2026) · ACS Omega · doi:10.1021/acsomega.5c07125
Nazar, V., Buxton, L. P., Jiang, S., Culick, A. I., Stiegel, M. K., Durbin, Z. I., Cripps, A. L., Gaines, B. L., McCormick, C. H., Vyavahare, N. R., et al. (2026) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c01891
Brightly Fluorescent Self-Assembled Supra-J-Aggregate Nanoparticles for Bioanalysis and Imaging
Kaj, J., Traaseth, C., Bernal-Escalante, J., Kim, S. H., Kamal, S., Wang, Y., Baker, D. G., Leicht, E., Darwish, G. H., Rees, K., et al. (2026) · ACS Nano · doi:10.1021/acsnano.6c04900
Kawelah, M. R., Dinçer, C. A., Jeevarathinam, A. S., Han, S., John, S., Brisola, J., Dileep, J., Kamath, A., Chen, M., Bouchard, R. R., et al. (2026) · ACS Applied Bio Materials · doi:10.1021/acsabm.6c00107
Self-citationPriya Jayathsena, R., Daimary, U. D., Kunnumakkara, A. B., & Mahata, K. (2026) · Chemistry - A European Journal · doi:10.1002/chem.71630
- Authors
- Changalvaie, B., Han, S., Moaseri, E., Scaletti, F., Truong, L., Caplan, R., Cao, A., Bouchard, R., Truskett, T. M., Sokolov, K. V., & Johnston, K. P.
- Affiliations
- Texas Materials Institute (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Johnston, Keith P.
- ORCID
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-12-05
- Volume
- 11
- Issue
- 50
- Pages
- 46437-46450
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2994591510
- Cited by
- 93
- References
- 70
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 21 · 2023: 18 · 2022: 16 · 2021: 5 · 2020: 4
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Welch Foundation (F-1696, F-1319)
- Cancer Prevention and Research Institute of Texas (RP170314)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- indocyanine green, J-aggregates, polymersomes, breast cancer, ovarian cancer, cancer cell imaging, polyethyleneimine coating, water-in-oil-in-water emulsion, contrast media
- MeSH terms
- Animals, Breast Neoplasms, Contrast Media, Emulsions, Female, Humans, Indocyanine Green, Mice, Nude, Oils, Ovarian Neoplasms, Polyethylene Glycols, Polyglactin 910, Water, Cell Line, Tumor, Mice, Nanocapsules, Molecular Imaging, Photoacoustic Techniques
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