Ionizing Radiation-Induced Release from Poly(ε-caprolactone- b -ethylene glycol) Micelles
Open accessAbstract
Abstract Polymeric micelles, due to their easy preparation and versatile properties, have been widely applied as one of the most popular carriers for chemotherapeutic agents. Such micelles primarily prevent the leakage of drugs during transportation and thus protect healthy tissue. Controlled drug release, which releases the drugs at the site of interest using internal or external stimuli as triggers, can further improve the safety of the drug delivery process. In this paper, we investigate whether ionizing radiation can be used to initiate release, focusing on using Cerenkov light as a possible trigger. For this purpose, micelles composed of the degradable polymer poly(ε-caprolactone-b-ethylene glycol) (PCL-PEO) were first loaded with the photosensitizer chlorin e6 (Ce6) and subsequently exposed to gamma or X-ray radiation of varying radiation doses. The results reveal that Ce6 was released from the micelles under radiation, regardless of the energy of incident photons, showing that Cerenkov light was not the driving force behind the observed release. SANS measurements showed that the volume fraction of the micelles containing Ce6 was reduced after exposure to radiation. This change in volume fraction suggests that the number of micelles was reduced, which was probably responsible for the release of Ce6. The exact mechanism, however, remains unclear. Subsequently, the PCL-PEO micelles were loaded with Ce6 and one of the following drugs: doxorubicin (Dox), docetaxel (DTX), and paclitaxel (PTX). Under radiation exposure, Dox, which is quite stable in single-loaded micelles, shows an enhanced release profile in the presence of Ce6, while DTX and PTX remained in the micelles, regardless of the presence of Ce6.
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Liu and coworkers prepared polymeric micelles and utilized radiations as an external trigger to release doxorubicin, docetaxel, and paclitaxel from micelles.
“Liu and coworkers prepared polymeric micelles and utilized radiations as an external trigger to release the drugs (doxorubicin, docetaxel, and paclitaxel) from micelles.”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [120]
Enhanced release of doxorubicin was observed in the presence of photosensitizer chlorin (Ce6) and radiation exposure.
“Enhanced release of doxorubicin was observed in the presence of photosensitizer chlorin (Ce6) and radiation exposure [120].”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [120]
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- Authors
- Liu, H., Laan, A. C., Plomp, J., Parnell, S. R., Men, Y., Dalgliesh, R. M., Eelkema, R., & Denkova, A. G.
- Affiliations
- Delft University of Technology (NL)
- Rutherford Appleton Laboratory (GB)
- Corresponding author
- Eelkema, Rienk
- Denkova, Antonia G.
- ORCID
- Venue
- ACS Applied Polymer Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-12-30
- Volume
- 3
- Issue
- 2
- Pages
- 968-975
- ISSN
- 2637-6105 (ISSN-L)
- OpenAlex
- W3113805202
- Cited by
- 18
- References
- 31
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 2
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- ACS Applied Polymer Materials (publishedVersion, cc-by-nc-nd)
- Science and Technology Facilities Council (submittedVersion)
- Research Repository (Delft University of Technology) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc-nd)
- Funders
- Horizon 2020 Framework Programme (654000)
- China Scholarship Council (201707040083)
- Dutch beam time allocation (RB1969004)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- polymeric micelles, Cherenkov radiation, chlorin e6, photosensitizers, gamma radiation, X-rays, doxorubicin, docetaxel, paclitaxel, drug delivery, radiation dose dependence
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