Blood Oxygenation Using Fluoropolymer-Based Artificial Lung Membranes
Abstract
Artificial lung (AL) membranes are used for blood oxygenation for patients undergoing open-heart surgery or acute lung failures. Current AL technology employs polypropylene and polymethylpentene membranes. Although effective, these membranes suffer from low biocompatibility, leading to undesired blood coagulation and hemolysis over a long term. In this work, we propose a new generation of AL membranes based on amphiphobic fluoropolymers. We employed poly(vinylidene- co -hexafluoropropylene), or PVDF- co -HFP, to fabricate macrovoid-free membranes with an optimal pore size range of 30–50 nm. The phase inversion behavior of PVDF- co -HFP was investigated in detail for structural optimization. To improve the wetting stability of the membranes, the fabricated membranes were coated using Hyflon AD60X, a type of fluoropolymer with an extremely low surface energy. Hyflon-coated materials displayed very low protein adsorption and a high contact angle for both water and blood. In the hydrophobic spectrum, the data showed an inverse relationship between the surface free energy and protein adsorption, suggesting an appropriate direction with respect to biocompatibility for AL research. The blood oxygenation performance was assessed using animal sheep blood, and the fabricated fluoropolymer membranes showed competitive performance to that of commercial polyolefin membranes without any detectable hemolysis. The data also confirmed that the bottleneck in the blood oxygenation performance was not the membrane permeance but rather the rate of mass transfer in the blood phase, highlighting the importance of efficient module design.
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In medical devices, fluoropolymer-based structures offer a superior and safer alternative to devices made from other types of polymers; polypropylene and polymethylpentene artificial lung membranes often exhibit inadequate biocompatibility, causing unwanted blood clotting and long-term hemolysis, whereas a novel fluoropolymer-based membrane has demonstrated optimal performance with no detectable
“For example, in the field of medical devices, fluoropolymer-based structures offer a superior and safer alternative to devices made from other types of polymers; when polypropylene and polymethylpentene are used to make artificial lung membranes for blood oxygenation during open-heart surgery or acute lung failure, they often exhibit inadequate biocompatibility, resulting in unwanted blood”
From The EU’s Per- and Polyfluoroalkyl Substances (PFAS) Ban: A Case of Policy over Science (2023) · cites this paper as [81]
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- Authors
- Park, A., Song, Y., Yi, E., Duy Nguyen, B. T., Han, D., Sohn, E., Park, Y., Jung, J., Lee, Y. M., Cho, Y. H., & Kim, J. F.
- Affiliations
- Korea Research Institute of Chemical Technology (KR)
- Department of Energy and Chemical Engineering, Incheon National University, Incheon 22012, Republic of Korea
- Interface Material and Chemical Engineering Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 305-600, Republic of Korea
- Membrane Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 305-600, Republic of Korea
- Hanyang University (KR)
- Incheon National University (KR)
- Corresponding author
- Cho, Young Hoon
- Kim, Jeong F.
- Venue
- ACS Biomaterials Science & Engineering
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-10-26
- Volume
- 6
- Issue
- 11
- Pages
- 6424-6434
- ISSN
- 2373-9878 (ISSN-L)
- OpenAlex
- W3095168245
- Cited by
- 54
- References
- 50
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 14 · 2023: 16 · 2022: 7 · 2021: 6
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Biomaterials Science & Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea Research Institute of Chemical Technology (BSF20-254)
- National Research Foundation of Korea (2019M3E6A106479912, 2019R1G1A109477811, 2020R1C1C100787611)
- Korea Toray Science Foundation (2019)
- Topics
- Physical Sciences › Environmental Science › Water Science and Technology › Membrane Separation Technologies
- Physical Sciences › Engineering › Mechanical Engineering › Membrane Separation and Gas Transport
- Physical Sciences › Engineering › Biomedical Engineering › Mechanical Circulatory Support Devices
- Keywords
- blood oxygenation, fluorinated polymers, poly(vinylidene fluoride-co-hexafluoropropylene), phase inversion, protein adsorption, biocompatibility, hemolysis, coagulation, surface energy, mass transfer, membrane permeance, open heart surgery, acute lung failure
- MeSH terms
- Adsorption, Animals, Humans, Lung, Membranes, Membranes, Artificial, Polyvinyls, Sheep
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