Cited by 189Cellular Mechanics and InteractionsBone Tissue Engineering MaterialsTissue Engineering and Regenerative Medicine

Influence of Surface Topographical Cues on the Differentiation of Mesenchymal Stem Cells in Vitro

Metavarayuth, Kamolrat, Sitasuwan, Pongkwan, Zhao, Xia, Lin, Yuan, Wang, Qian·2016·ACS Biomaterials Science & Engineering

Abstract

Adult stem cell research has been advanced in recent years because of the cells' attractive abilities of self-renewal and differentiation. Topography of materials is one of the key features that can be harnessed to regulate stem cell behaviors. Stem cells can interact with underlying material through nanosized integrin receptors. Therefore, the manipulation of topographical cues at a nanoscale level can be employed to modulate the cell fate. In this review, we focus our discussion on the different surface topographical cues, especially, with an emphasis on the viral nanoparticle-coated materials, and their effects on stem cell differentiation.

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Crossref · 10.1021/acsbiomaterials.5b00377

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94 of 94 references verified0 citation errors · 0 not checkable

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  • Cells interact with neighboring cells and respond to external stimuli collectively.

    “it is now known that cells interact with their neighbors and respond to external stimuli in a collective manner24.”

    From Organoids (2022) · cites this paper as [24]

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Authors
Metavarayuth, K., Sitasuwan, P., Zhao, X., Lin, Y., & Wang, Q.
Affiliations
  • University of South Carolina (US)
  • Chinese Academy of Sciences (CN)
Corresponding author
Wang, Qian
Venue
ACS Biomaterials Science & Engineering
Published
2016-01-11
Volume
2
Issue
2
Pages
142-151
ISSN
2373-9878 (ISSN-L)
OpenAlex
W2220162928
Cited by
189
References
94
Citations by year
2026: 6 · 2025: 10 · 2024: 12 · 2023: 19 · 2022: 29 · 2021: 32 · 2020: 20 · 2019: 18 · 2018: 18 · 2017: 19 · 2016: 6
FWCI
6.88
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Biomaterials Science & Engineering (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Division of Chemistry (CHE-1307319)
  • National Natural Science Foundation of China (21374119, 21429401)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
mesenchymal stem cells, surface topography, stem cell differentiation, nanoscale topography, integrins, cell fate regulation, biomaterials

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