Influence of Surface Topographical Cues on the Differentiation of Mesenchymal Stem Cells in Vitro
Abstract
Adult stem cell research has been advanced in recent years because of the cells' attractive abilities of self-renewal and differentiation. Topography of materials is one of the key features that can be harnessed to regulate stem cell behaviors. Stem cells can interact with underlying material through nanosized integrin receptors. Therefore, the manipulation of topographical cues at a nanoscale level can be employed to modulate the cell fate. In this review, we focus our discussion on the different surface topographical cues, especially, with an emphasis on the viral nanoparticle-coated materials, and their effects on stem cell differentiation.
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Cells interact with neighboring cells and respond to external stimuli collectively.
“it is now known that cells interact with their neighbors and respond to external stimuli in a collective manner24.”
From Organoids (2022) · cites this paper as [24]
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Zhao, Z., Chen, X., Dowbaj, A. M., Sljukic, A., Bratlie, K., Lin, L., Fong, E. L. S., Balachander, G. M., Chen, Z., Soragni, A., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00174-y · Cited by 1,001 · see citing works
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- Authors
- Metavarayuth, K., Sitasuwan, P., Zhao, X., Lin, Y., & Wang, Q.
- Affiliations
- University of South Carolina (US)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Wang, Qian
- Venue
- ACS Biomaterials Science & Engineering
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-01-11
- Volume
- 2
- Issue
- 2
- Pages
- 142-151
- ISSN
- 2373-9878 (ISSN-L)
- OpenAlex
- W2220162928
- Cited by
- 189
- References
- 94
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 12 · 2023: 19 · 2022: 29 · 2021: 32 · 2020: 20 · 2019: 18 · 2018: 18 · 2017: 19 · 2016: 6
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Biomaterials Science & Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Division of Chemistry (CHE-1307319)
- National Natural Science Foundation of China (21374119, 21429401)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- mesenchymal stem cells, surface topography, stem cell differentiation, nanoscale topography, integrins, cell fate regulation, biomaterials
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