The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Mimicking Melanosomes: Polydopamine Nanoparticles as Artificial Microparasols
Open accessAbstract
A primary role of melanin in skin is the prevention of UV-induced nuclear DNA damage to human skin cells, where it serves to screen out harmful UV radiation. Melanin is delivered to keratinocytes in the skin after being excreted as melanosomes from melanocytes. Defects in melanin production in humans can cause diseases, many of which currently lack effective treatments due to their genetic origins (e.g., skin cancer, vitiligo, and albinism). The widespread prevalence of melanin-related diseases and an increasing interest in the performance of various polymeric materials related to melanin necessitates novel synthetic routes for preparing melanin-like materials. In this work, we prepared melanin-like nanoparticles (MelNPs) via spontaneous oxidation of dopamine, as biocompatible, synthetic analogues of naturally occurring melanosomes, and investigated their uptake, transport, distribution, and UV-protective capabilities in human keratinocytes. Critically, we demonstrate that MelNPs are endocytosed, undergo perinuclear aggregation, and form a supranuclear cap, or so-called microparasol in human epidermal keratinocytes (HEKa), mimicking the behavior of natural melananosomes in terms of cellular distribution and the fact that they serve to protect the cells from UV damage.
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Cites
Liu, Y., Ai, K., & Lu, L. (2014) · Chemical Reviews · doi:10.1021/cr400407a · Cited by 4,794
Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure
Premi, S., Wallisch, S., Mano, C. M., Weiner, A. B., Bacchiocchi, A., Wakamatsu, K., Bechara, E. J. H., Halaban, R., Douki, T., & Brash, D. E. (2015) · Science · doi:10.1126/science.1256022 · Cited by 550 · cited 1×
“7,49,50 Therefore, we tested for protective qualities of MelNPs by analyzing DNA damage in HEKa cells after treatment with MelNPs followed by UV irradiation (Figure 5).”
UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin
Tadokoro, T., Kobayashi, N., Zmudzka, B. Z., Ito, S., Wakamatsu, K., Yamaguchi, Y., Korossy, K. S., Miller, S. A., Beer, J. Z., & Hearing, V. J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0865fje · Cited by 378
Hong, L., & Simon, J. D. (2007) · The Journal of Physical Chemistry B · doi:10.1021/jp071439h · Cited by 360
The supramolecular structure of melanin
Watt, A. A. R., Bothma, J. P., & Meredith, P. (2009) · Soft Matter · doi:10.1039/b902507c · Cited by 308
Simon, J. D., & Peles, D. N. (2010) · Accounts of Chemical Research · doi:10.1021/ar100079y · Cited by 296
Ando, H., Niki, Y., Ito, M., Akiyama, K., Matsui, M. S., Yarosh, D. B., & Ichihashi, M. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.413 · Cited by 258
Supranuclear melanin caps reduce ultraviolet induced DNA photoproducts in human epidermis
Kobayashi, N., Nakagawa, A., Muramatsu, T., Yamashina, Y., Shirai, T., Hashimoto, M. W., Ishigaki, Y., Ohnishi, T., & Mori, T. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00178.x · Cited by 257
Neuromelanin of the Human Substantia Nigra: An Update
Zucca, F. A., Basso, E., Cupaioli, F. A., Ferrari, E., Sulzer, D., Casella, L., & Zecca, L. (2014) · Neurotoxicity Research · doi:10.1007/s12640-013-9435-y · Cited by 243
Trace Metals as Biomarkers for Eumelanin Pigment in the Fossil Record
Wogelius, R. A., Manning, P. L., Barden, H. E., Edwards, N. P., Webb, S. M., Sellers, W. I., Taylor, K. G., Larson, P. L., Dodson, P., You, H., et al. (2011) · Science · doi:10.1126/science.1205748 · Cited by 180
Cited by
Chemistry of Polydopamine – Scope, Variation, and Limitation
Liebscher, J. (2019) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201900445 · Cited by 283
Opsin 3 mediates UVA-induced keratinocyte supranuclear melanin cap formation
Lan, Y., Zeng, W., Wang, Y., Dong, X., Shen, X., Gu, Y., Zhang, W., & Lu, H. (2023) · Communications Biology · doi:10.1038/s42003-023-04621-8 · Cited by 22
Metadata
- Authors
- Huang, Y., Li, Y., Hu, Z., Yue, X., Proetto, M. T., Jones, Y., & Gianneschi, N. C.
- Venue
- ACS Central Science
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-05-18
- Volume
- 3
- Issue
- 6
- Pages
- 564-569
- ISSN
- 2374-7943 (ISSN-L)
- 2374-7951
- OpenAlex
- W2615709841
- Cited by
- 162
- References
- 13
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Huang, Y., Li, Y., Hu, Z., Yue, X., Proetto, M. T., Jones, Y., & Gianneschi, N. C. (2017). Mimicking Melanosomes: Polydopamine Nanoparticles as Artificial Microparasols. ACS Central Science. https://doi.org/10.1021/acscentsci.6b00230
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