Vascular Endothelial Growth Factor (VEGF) as a Vital Target for Brain Inflammation during the COVID-19 Outbreak
Abstract
The coronavirus disease 19 (COVID-19) pandemic has brought a great threat to global public health. Currently, mounting evidence has shown the occurrence of neurological symptoms in patients with COVID-19. However, the detailed mechanism by which the SARS-CoV-2 attacks the brain is not well characterized. Recent investigations have revealed that a cytokine storm contributes to brain inflammation and subsequently triggers neurological manifestations during the COVID-19 outbreak. Targeting brain inflammation may provide significant clues to the treatment of neurologic complications caused by SARS-CoV-2. Vascular growth factor (VEGF), which is widely distributed in the brain, probably plays a crucial role in brain inflammation via facilitating the recruitment of inflammatory cells and regulating the level of angiopoietins II (Ang II). Also, Ang II is considered as the products of SARS-CoV-2-attacking target, angiotensin-converting enzyme 2 (ACE2). Further investigation of the therapeutic potential and the underlying mechanisms of VEGF-targeted drugs on the neurological signs of COVID-19 are warranted. In any case, VEGF is deemed a promising therapeutic target in suppressing inflammation during SARS-CoV-2 infection with neurological symptoms.
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The COVID-19 entry receptor ACE2 activates RAAS for neuroinflammation and VEGF synthesis by Ang II binding to AT1R.
“The COVID-19 entry receptor ACE2 activates RAAS for neuroinflammation and VEGF synthesis by Ang II binding to AT1R (reviewed in ref. [167]).”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [167]
Increasing VEGF concentrations recruit inflammatory cells into the brain and sustain neuroinflammation, and have been named as target for COVID-19 treatment.
“Finally, increasing VEGF concentrations, which recruit inflammatory cells into the brain and sustain neuroinflammation, have been named as target for COVID-19 treatment [167].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [167]
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- Authors
- Yin, X.-X., Zheng, X.-R., Peng, W., Wu, M.-L., & Mao, X.-Y.
- Affiliations
- Central South University (CN)
- Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, 410008 Hunan Province, China
- Corresponding author
- Zheng, Xiang-Rong
- Mao, Xiao-Yuan
- ORCID
- Mao, Xiao-Yuan
- Venue
- ACS Chemical Neuroscience
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-06-02
- Volume
- 11
- Issue
- 12
- Pages
- 1704-1705
- ISSN
- 1948-7193 (ISSN-L)
- OpenAlex
- W3028897674
- Cited by
- 72
- References
- 6
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 13 · 2022: 17 · 2021: 26 · 2020: 9
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Chemical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81873851)
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- vascular endothelial growth factor, COVID-19 pandemic, SARS-CoV-2, neuroinflammation, neurological complications, cytokine storm, angiotensin-converting enzyme 2, anti-VEGF therapy
- MeSH terms
- Betacoronavirus, Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, Angiotensin I, Angiotensin II, Blood-Brain Barrier, Brain, Humans, Inflammation, Peptidyl-Dipeptidase A, Pneumonia, Viral, Cytokines, Coronavirus Infections, Vascular Endothelial Growth Factor A, Pandemics
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