Amyloid plaque-associated oxidative degradation of uniformly radiolabeled arachidonic acid
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Oxidative stress is a frequently observed feature of Alzheimer's disease, but its pathological significance is not understood. To explore the relationship between oxidative stress and amyloid plaques, uniformly radiolabeled arachidonate was introduced into transgenic mouse models of Alzheimer's disease via intracerebroventricular injection. Uniform labeling with carbon-14 is used here for the first time, and made possible meaningful quantification of arachidonate oxidative degradation products. The injected arachidonate entered a fatty acid pool that was subject to oxidative degradation in both transgenic and wild-type animals. However, the extent of its degradation was markedly greater in the hippocampus of transgenic animals where amyloid plaques were abundant. In human Alzheimer's brain, plaque-associated proteins were post-translationally modified by hydroxynonenal, a well-known oxidative degradation product of arachidonate. These results suggest that several recurring themes in Alzheimer's pathogenesis, amyloid β proteins, transition metal ions, oxidative stress, and apolipoprotein isoforms, may be involved in a common mechanism that has the potential to explain both neuronal loss and fibril formation in this disease.
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Increased biomarkers of oxidative stress, inflammation and chronic neuroinflammation are associated with many neurodegenerative disorders of the central nervous system, including Alzheimer's disease.
“Increased biomarkers of oxidative stress (Furman et al., 2016), inflammation and chronic neuroinflammation are reported to be associated with many neurodegenerative disorders of central nervous system (CNS) including AD (Leszek et al., 2016).”
From Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial (2016) · cites this paper as Furman et al., 2016
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1 retracted
Rao, J. S., Rapoport, S. I., & Kim, H. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.27 · Cited by 86 · see citing works
RetractedCorder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · see citing works
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920 · see citing works
Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works
APP Processing and Synaptic Function
Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644 · see citing works
Polyunsaturated fatty acids and their metabolites in brain function and disease
Bazinet, R. P., & Layé, S. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3820 · Cited by 1,613 · see citing works
4-Hydroxy-2-nonenal: a product and mediator of oxidative stress
Uchida, K. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00014-6 · Cited by 1,164 · see citing works
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease
Giannakopoulos, P., Herrmann, F. R., Bussière, T., Bouras, C., Kövari, E., Perl, D. P., Morrison, J. H., Gold, G., & Hof, P. R. (2003) · Neurology · doi:10.1212/01.wnl.0000063311.58879.01 · Cited by 1,118 · see citing works
Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
Selkoe, D. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.016 · Cited by 1,038 · see citing works
Sayre, L., Zelasko, D. A., Harris, P. L. R., Perry, G., Salomon, R. G., & Smith, M. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052092.x · Cited by 1,032 · see citing works
Butterfield, D. A., & Lauderback, C. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00794-3 · Cited by 999 · see citing works
Merritt, H. H., FREMONT-SMITH, F., & Ayer, J. B. (1938) · The American Journal of the Medical Sciences · doi:10.1097/00000441-193804000-00024 · Cited by 876 · see citing works
Koffie, R. M., Meyer-Luehmann, M., Hashimoto, T., Adams, K. W., Mielke, M. L., Garcia-Alloza, M., Micheva, K. D., Smith, S. J., Kim, M. L., Lee, V. M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811698106 · Cited by 850 · see citing works
Mark, R. J., Lovell, M. A., Markesbery, W. R., Uchida, K., & Mattson, M. P. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68010255.x · Cited by 781 · see citing works
Praticò, D., Uryu, K., Leight, S., Trojanoswki, J. Q., & Lee, V. M.-Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04183.2001 · Cited by 777 · see citing works
Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis
Kruman, I. I., Bruce‐Keller, A. J., Bredesen, D. E., Waeg, G., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05089.1997 · Cited by 719 · see citing works
Markesbery, W. R., & Lovell, M. A. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00009-8 · Cited by 680 · see citing works
Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress
Smith, M. A., Hirai, K., Hsiao, K., Pappolla, M. A., Harris, P. L. R., Siedlak, S. L., Tabaton, M., & Perry, G. L. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70052212.x · Cited by 547 · see citing works
Montine, T. J., Neely, M. D., Quinn, J. F., Beal, M. F., Markesbery, W. R., Roberts, L. J., & Morrow, J. D. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00807-9 · Cited by 449 · see citing works
Acrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures
Lovell, M. A., Xie, C., & Markesbery, W. R. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00235-9 · Cited by 449 · see citing works
Keller, J. N., Pang, Z., Geddes, J. W., Begley, J. G., Germeyer, A., Waeg, G., & Mattson, M. P. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69010273.x · Cited by 439 · see citing works
Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease
Lovell, M. A., Ehmann, W. D., Mattson, M. P., & Markesbery, W. R. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00108-5 · Cited by 413 · see citing works
Pratico, D., Lee, V. M.-Y., Trojanowski, J. Q., Rokach, J., & Fitzgerald, G. A. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.15.1777 · Cited by 405 · see citing works
Cuajungco, M. P., Goldstein, L. E., Nunomura, A., Smith, M. A., Lim, J. T., Atwood, C., Huang, X., Farrag, Y. W., Perry, G. L., & Bush, A. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000165200 · Cited by 392 · see citing works
Williams, T. I., Lynn, B. C., Markesbery, W. R., & Lovell, M. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.06.004 · Cited by 391 · see citing works
Oxidative injury in diseases of the central nervous system: focus on alzheimer’s disease
Praticò, D., & Delanty, N. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00547-7 · Cited by 378 · see citing works
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
Sanchez-Mejia, R. O., Newman, J. W. I., Toh, S., Yu, G.-Q., Zhou, Y., Halabisky, B., Cissé, M., Scearce-Levie, K. A., Cheng, I. H.-J., Gan, L., et al. (2008) · Nature Neuroscience · doi:10.1038/nn.2213 · Cited by 369 · see citing works
Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease
Resende, R., Moreira, P. I., Proença, T., Deshpande, A., Busciglio, J., Pereira, C., & Oliveira, C. R. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.012 · Cited by 343 · see citing works
Abramov, A. Y., Canevari, L., & Duchen, M. R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05088.2003 · Cited by 337 · see citing works
Vohr, H.-W. (2015) · Springer eBooks · doi:10.1007/978-3-642-54596-2_201199 · Cited by 336 · see citing works
Two Distinct Pathways of Formation of 4-Hydroxynonenal
Schneider, C., Tallman, K. A., Porter, N. A., & Brash, A. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101821200 · Cited by 313 · see citing works
The Role of Oxidative Stress in Alzheimer Disease
Markesbery, W. R. (1999) · Archives of Neurology · doi:10.1001/archneur.56.12.1449 · Cited by 307 · see citing works
Kardos, J., Kovács, I., Hajós, F., Kálmán, M., & Simonyi, M. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90565-x · Cited by 298 · see citing works
Nelson, P. T., Jicha, G. A., Schmitt, F. A., Liu, H., Davis, D. G., Mendiondo, M. S., Abner, E. L., & Markesbery, W. R. (2007) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/nen.0b013e31815c5efb · Cited by 292 · see citing works
Copper and Oxidative Stress in the Pathogenesis of Alzheimer’s Disease
Eskici, G., & Axelsen, P. H. (2012) · Biochemistry · doi:10.1021/bi3006169 · Cited by 288 · see citing works
Self-citationRoutes to 4-Hydroxynonenal: Fundamental Issues in the Mechanisms of Lipid Peroxidation
Schneider, C. G., Porter, N. A., & BRASH, A. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800001200 · Cited by 275 · see citing works
Butterfield, D. A., & Debra Boyd-kimball, A. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00087.x · Cited by 263 · see citing works
Lipid Peroxidation and Free Radical Scavengers in Alzheimer’s Disease
Jeandel, C., Nicolas, M. B., Dubois, F., Belleville, F., Penin, F., & Cuny, G. (2009) · Gerontology · doi:10.1159/000213037 · Cited by 250 · see citing works
Liu, J. J., Green, P., Mann, J. J., Rapoport, S. I., & Sublette, M. E. (2014) · Brain Research · doi:10.1016/j.brainres.2014.11.059 · Cited by 234 · see citing works
Deshpande, A., Kawai, H., Metherate, R., Glabe, C. G., & Busciglio, J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5980-08.2009 · Cited by 232 · see citing works
Piro, J. R., Benjamin, D. I., Duerr, J. M., Pi, Y., Gonzales, C., Wood, K. M., Schwartz, J. W., Nomura, D. K., & Samad, T. A. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.05.001 · Cited by 223 · see citing works
Montine, K. S., Olson, S. J., Amarnath, K., Whetsell, W. O., Graham, D. G., & Montine, T. J. (1997) · Europe PMC (PubMed Central) · Cited by 220 · see citing works
Takeda, A., Smith, M. A., Ávila, J., Nunomura, A., Siedlak, S. L., Zhu, X., Perry, G. L., & Sayre, L. M. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751234.x · Cited by 203 · see citing works
DeMar, J. C., Ma, K., Bell, J. M., & Rapoport, S. I. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02789.x · Cited by 194 · see citing works
Role of 4-hydroxynonenal in stress-mediated apoptosis signaling
Awasthi, S., Sharma, R., Cheng, J. Z., Yang, Y., Sharma, A., Singhal, S. S., & Awasthi, S. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(03)00017-7 · Cited by 192 · see citing works
Hartter, D. E., & Barnea, A. (1988) · Synapse · doi:10.1002/syn.890020408 · Cited by 185 · see citing works
Role of Free Radicals and Metal Ions in the Pathogenesis of Alzheimer’s Disease
Atwood, C. S., Huang, X., Moir, R. D., Tanzi, R. E., & Bush, A. I. (2018) · Routledge eBooks · doi:10.1201/9780203747605-10 · Cited by 183 · see citing works
Trans-4-hydroxy-2-hexenal, a product of n-3 fatty acid peroxidation: Make some room HNE…
Long, E. K., & Picklo, M. J. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.015 · Cited by 178 · see citing works
Khachaturian, A. S. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.5.518 · Cited by 176 · see citing works
4-Hydroxy-2-Nonenal Pyrrole Adducts in Human Neurodegenerative Disease
Montine, K. S., KIM, P. J., Olson, S. J., Markesbery, W. R., & Montine, T. J. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199708000-00004 · Cited by 158 · see citing works
Oxidative Stress and Cell Membranes in the Pathogenesis of Alzheimer's Disease
Axelsen, P. H., Komatsu, H., & Murray, I. V. J. (2011) · Physiology · doi:10.1152/physiol.00024.2010 · Cited by 158 · see citing works
Self-citationHistochemical detection of 4-hydroxynonenal protein in Alzheimer amyloid
Ando, Y., Brännström, T., Uchida, K., Nyhlin, N., Näsman, B., Suhr, O. B., Yamashita, T., Olsson, T., Salhy, M. E., Uchino, M., et al. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00042-2 · Cited by 152 · see citing works
Lipid peroxidation in neurodegeneration: new insights into Alzheimerʼs disease
Arlt, S., Beisiegel†, U., & Kontush, A. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200206000-00009 · Cited by 151 · see citing works
D’Amelio, M., & Rossini, P. M. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.07.001 · Cited by 144 · see citing works
Chen, K., Maley, J., & Yu, P. H. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04181.x · Cited by 131 · see citing works
Bielicki, J. K., & Oda, M. N. (2002) · Biochemistry · doi:10.1021/bi011716p · Cited by 131 · see citing works
Accelerated Accumulation of Amyloid β Proteins on Oxidatively Damaged Lipid Membranes
Koppaka, V., & Axelsen, P. H. (2000) · Biochemistry · doi:10.1021/bi000619d · Cited by 131 · see citing works
Self-citationA Mechanism for the Neuroprotective Effect of Apolipoprotein E
Pedersen, W. A., Chan, S. L., & Mattson, M. P. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741426.x · Cited by 130 · see citing works
Ting, J. T., Kelley, B. G., Lambert, T. J., Cook, D. G., & Sullivan, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608807104 · Cited by 129 · see citing works
Özçankaya, R., & Delibaş, N. (2002) · PubMed · Cited by 128 · see citing works
Wataya, T., Nunomura, A., Smith, M. A., Siedlak, S. L., Harris, P. L. R., Shimohama, S., Szweda, L. I., Kaminski, M. A., Ávila, J., Price, D. L., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110913200 · Cited by 128 · see citing works
Spitz, D. R., Malcolm, R. R., & Roberts, R. J. (1990) · Biochemical Journal · doi:10.1042/bj2670453 · Cited by 115 · see citing works
Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling
Chaudhary, P., Sharma, R., Sharma, A., Vatsyayan, R., Yadav, S., Singhal, S. S., Rauniyar, N., Prókai, L., Awasthi, S., & Awasthi, S. (2010) · Biochemistry · doi:10.1021/bi100517x · Cited by 114 · see citing works
Promotion of Oxidative Lipid Membrane Damage by Amyloid β Proteins
Murray, I. V. J., Sindoni, M. E., & Axelsen, P. H. (2005) · Biochemistry · doi:10.1021/bi050926p · Cited by 107 · see citing works
Self-citationMembrane-mediated Amyloidogenesis and the Promotion of Oxidative Lipid Damage by Amyloid β Proteins
Murray, I. V. J., Liu, L., Komatsu, H., Uryu, K., Xiao, G., Lawson, J. A., & Axelsen, P. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608589200 · Cited by 106 · see citing works
Self-citationDeGeorge, J. J., Noronha, J. G. L., Bell, J., Robinson, P., & Рапопорт, С. И. (1989) · Journal of Neuroscience Research · doi:10.1002/jnr.490240311 · Cited by 105 · see citing works
Hydroxynonenal, toxic carbonyls, and Alzheimer disease
Liu, Q., Raina, A. K., Smith, M. A., Sayre, L. M., & Perry, G. L. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(03)00025-6 · Cited by 105 · see citing works
Self-citationIntracerebral injections and the growth of viruses in the mouse brain.
MIMS, C. A. (1960) · PubMed · Cited by 104 · see citing works
Chen, C. T., Liu, Z., & Bazinet, R. P. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07116.x · Cited by 97 · see citing works
Trans‐4‐hydroxy‐2‐hexenal is a neurotoxic product of docosahexaenoic (22:6; n‐3) acid oxidation
Long, E. K., Murphy, T. C., Leiphon, L. J., Watt, J. A., Morrow, J. D., Milne, G. L., Howard, J. R. H., & Picklo, M. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05175.x · Cited by 97 · see citing works
Grune, T., Wg, S., Zöllner, H., & Esterbauer, H. (1994) · PubMed · Cited by 92 · see citing works
Copper catalyzed oxidation of Alzheimer Abeta.
Atwood, C. S., Huang, X., Khatri, A., Scarpa, R. C., Kim, Y. S., Moir, R. D., Tanzi, R. E., Roher, A. E., & Bush, A. I. (2000) · PubMed · Cited by 89 · see citing works
Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo
Huang, Y., Jin, M.-H., Pi, R., Zhang, J., Ouyang, Y., Chao, X., Chen, M.-H., Liu, P., Yu, J., Ramassamy, C., et al. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2012.12.023 · Cited by 88 · see citing works
Yao, Y., Zhukareva, V., Sung, S., Clark, C. M., Rokach, J., Lee, V. M.-Y., Trojanowski, J. Q., & Praticò, D. (2003) · Neurology · doi:10.1212/01.wnl.0000070185.02546.5d · Cited by 86 · see citing works
Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-β peptide
Hayashi, T., Shishido, N., Nakayama, K., Nunomura, A., Smith, M. A., Perry, G. L., & Nakamura, M. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.013 · Cited by 84 · see citing works
Promotion of Amyloid β Protein Misfolding and Fibrillogenesis by a Lipid Oxidation Product
Liu, L., Komatsu, H., Murray, I. V. J., & Axelsen, P. H. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.01.057 · Cited by 81 · see citing works
Self-citationRofina, J., Singh, K., Skoumalova-Vesela, A., van Ederen, A. M., van Asten, A. J., Wilhelm, J., & Gruys, E. (2004) · Amyloid · doi:10.1080/13506120412331285779 · Cited by 79 · see citing works
The neurobiology of isoprostanes and Alzheimer's disease
Praticò, D. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.01.009 · Cited by 65 · see citing works
Prostaglandin H2‐derived adducts of proteins correlate with Alzheimer's disease severity
Zagol-Ikapitte, I. A., Masterson, T. S., Amarnath, V., Montine, T. J., Andreasson, K. I., Boutaud, O. G., & Oates, J. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03264.x · Cited by 62 · see citing works
Lysenko, L. V., Kim, J., Henry, C. L., Tyrtyshnaia, A. A., Kohnz, R. A., Madamba, F., Simon, G. M., Kleschevnikova, N. E., Nomura, D. K., Ezekowitz, R. A. B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114521 · Cited by 57 · see citing works
Bassett, C. N., Neely, M. D., Sidell, K. R., Markesbery, W. R., Switt, L. L., & Montine, T. J. (1999) · Lipids · doi:10.1007/s11745-999-0478-1 · Cited by 56 · see citing works
Koppaka, V., Paul, C., Murray, I. V. J., & Axelsen, P. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301334200 · Cited by 56 · see citing works
Self-citationUllrich, O., Grune, T., Henke, W., Esterbauer, H., & Siems, W. G. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00922-8 · Cited by 53 · see citing works
Dinamarca, M. C., Weinstein, D. B., Monasterio, O., & Inestrosa, N. C. (2011) · Biochemistry · doi:10.1021/bi201246t · Cited by 53 · see citing works
Elevated glutathione as a therapeutic strategy in Alzheimer's disease
Butterfield, D. A., Pocernich, C. B., & Drake, J. (2002) · Drug Development Research · doi:10.1002/ddr.10095 · Cited by 51 · see citing works
Lin, L. E., Chen, C. T., Hildebrand, K. D., Liu, Z., Hopperton, K. E., & Bazinet, R. P. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m055590 · Cited by 48 · see citing works
Miller, V. M., Lawrence, D. A., Mondal, T. K., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.029 · Cited by 44 · see citing works
Komatsu, H., Liu, L., Murray, I. V. J., & Axelsen, P. H. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.05.026 · Cited by 36 · see citing works
Self-citationCyclooxygenase-Dependent Lipid-Modification of Brain Proteins
Boutaud, O. G., Andreasson, K. I., Zagol-Ikapitte, I. A., & Oates, J. A. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00510.x · Cited by 29 · see citing works
Bai, J., & Yuanwu, M. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9183-1 · Cited by 29 · see citing works
Magni, F., Galbusera, C., Tremolada, L., Ferrarese, C., & Kienle, M. G. (2002) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.743 · Cited by 27 · see citing works
Lipid Oxidation and Modification of Amyloid-β (Aβ) in vitro and in vivo
Ellis, G., Fang, E., Maheshwari, M., Roltsch, E. A., Holcomb, L. A., Zimmer, D. B., Martínez, D., & Murray, I. V. J. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100960 · Cited by 23 · see citing works
Self-citationSOME SHORTCOMINGS OF DIRECT INTRAVENTRICULAR INJECTION IN MICE
Shaw, G. G. (1974) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1974.tb08596.x · Cited by 11 · see citing works
Hamdan, S., & A-I, A. (2006) · Cited by 10 · see citing works
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Akbari, E., Asemi, Z., Daneshvar Kakhaki, R., Bahmani, F., Kouchaki, E., Tamtaji, O. R., Hamidi, G. A., & Salami, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00256 · Cited by 946 · see citing works
Ansari, F., Pourjafar, H., Tabrizi, A., & Homayouni, A. (2020) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201021666200107113812 · Cited by 170 · see citing works
Ayton, S., & Bush, A. I. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101212 · Cited by 45 · see citing works
- Authors
- Furman, R., Murray, I. V. J., Schall, H. E., Liu, Q., Ghiwot, Y., & Axelsen, P. H.
- Affiliations
- University of Pennsylvania (US)
- St. George's University (GD)
- Texas A&M University (US)
- Corresponding author
- Axelsen, Paul H.
- Venue
- ACS Chemical Neuroscience
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-02-09
- Volume
- 7
- Issue
- 3
- Pages
- 367-377
- ISSN
- 1948-7193 (ISSN-L)
- PMC
- PMC5654537
- OpenAlex
- W2255742740
- Cited by
- 26
- References
- 96
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 5
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- ACS Chemical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS74178)
- Alzheimer's Association
- American Health Assistance Foundation
- Glenn Family Foundation
- National Institute of General Medical Sciences (GM76201)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- Alzheimer's disease, amyloid plaques, arachidonic acid, oxidative stress, 4-hydroxynonenal, carbon-14 labeling, transgenic mouse model, hippocampus, fatty acid oxidation, amyloid-beta, transition metal ions, neuronal loss, fibril formation
- MeSH terms
- Alzheimer Disease, Animals, Chromatography, High Pressure Liquid, Disease Models, Animal, Fluorescent Antibody Technique, Hippocampus, Humans, Mice, Transgenic, Mass Spectrometry, Amyloid beta-Peptides, Arachidonic Acid, Oxidative Stress, Mice, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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