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Electrostatically Driven Complex Coacervation and Amyloid Aggregation of Tau Are Independent Processes with Overlapping Conditions
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In the citing paper
“Tau phase separation can also be induced by a coacervation mechanism, whereby oppositely charged between tau and RNA spontaneously organize into higher order biomolecular condensates.13,14”
From A Proline-Rich-Domain-Binding Single Domain Antibody Selectively Inhibits RNA-Induced Phase Separation of Tau (2026) · cites this paper as [13]
In the citing paper
“TDP-43 and tau interaction promotes their co-condensation but also suppress tau fibril formation and seeding.10,13”
From A Proline-Rich-Domain-Binding Single Domain Antibody Selectively Inhibits RNA-Induced Phase Separation of Tau (2026) · cites this paper as [13]
In the citing paper
“On the other hand, studies have suggested that phase separation prevents the formation of oligomeric toxic tau species.”
From A Proline-Rich-Domain-Binding Single Domain Antibody Selectively Inhibits RNA-Induced Phase Separation of Tau (2026) · cites this paper as [13]
In the citing paper
“Notably, high concentrations of RNA do not induce Tau LLPS but can trigger Tau aggregation (Kampers et al, 1996) without the formation of liquid‐condensed intermediates (Lin et al, 2020).”
From Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates (2022) · cites this paper as Lin et al, 2020
In the citing paper
“In the case of Tau, polyanionic RNA (or heparin; Lin et al, 2020) co‐condensate with the positively charged Tau microtubule‐assembly domain into liquid‐like droplets (Zhang et al, 2017; Lin et al, 2019).”
From Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates (2022) · cites this paper as Lin et al, 2020
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Cites
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
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Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase
Hernández-Vega, A., Braun, M., Scharrel, L., Jahnel, M., Wegmann, S., Hyman, B. T., Alberti, S., Diez, S., & Hyman, A. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.042 · Cited by 395
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Liquid-liquid phase separation induces pathogenic tau conformations in vitro
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Metadata
- Authors
- Lin, Y., Fichou, Y., Zeng, Z., Hu, N. Y., & Han, S.
- Venue
- ACS Chemical Neuroscience
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-01-23
- Volume
- 11
- Issue
- 4
- Pages
- 615-627
- ISSN
- 1948-7193
- Cited by
- 107
- References
- 10
- Language
- en
- Licence
- Funders
- National Institute on Aging (R01AG056058)
- Rainwater Charitable Foundation
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.