Liquid-liquid phase separation in Alzheimer’s disease

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Phase separation drives heterochromatin domain formation

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Phase separation of signaling molecules promotes T cell receptor signal transduction

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G3BP1 is a tunable switch that triggers phase separation to assemble stress granules

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Tau protein liquid–liquid phase separation can initiate tau aggregation

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APP processing in Alzheimer’s disease.

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Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets

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FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

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Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus

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Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

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RNA-Binding Proteins in Cancer: Old Players and New Actors

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Liquid–liquid phase separation in human health and diseases

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RNA Controls PolyQ Protein Phase Transitions

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Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

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Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome

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Current understanding of metal ions in the pathogenesis of Alzheimer’s disease

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Liquid–liquid phase separation drives cellular function and dysfunction in cancer

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Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

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Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

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Alzheimer's disease, metal ions and metal homeostatic therapy

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Updated TDP-43 in Alzheimer’s disease staging scheme

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HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells

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Metal Ions in Alzheimer’s Disease: A Key Role or Not?

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Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

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Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation

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Binding of two zinc ions promotes liquid-liquid phase separation of Tau

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In vitro characterization and molecular dynamics simulation reveal mechanism of 14-3-3ζ regulated phase separation of the tau protein

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Sticker-and-spacer model for amyloid beta condensation and fibrillation

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Multivalent polymers can control phase boundary, dynamics, and organization of liquid-liquid phase separation

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Bexarotene drives the self‐renewing proliferation of adult neural stem cells, promotes neuron‐glial fate shift, and regulates late neuronal differentiation

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The kinetics of islet amyloid polypeptide phase-separated system and hydrogel formation are critically influenced by macromolecular crowding

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Towards prevention and therapy of Alzheimer's disease

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The Enigma of Tau Protein Aggregation: Mechanistic Insights and Future Challenges

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Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review

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Copper toxicity and deficiency: the vicious cycle at the core of protein aggregation in ALS

Min, J.-H., Sarlus, H., & Harris, R. A. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1408159 · Cited by 30 · see citing works

The role of liquid-liquid phase separation in the disease pathogenesis and drug development

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Functions of Intrinsically Disordered Regions

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ca-circSCN8A Promotes HPASMCs Ferroptosis via LLPS Initiated R-Loop

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Tau Liquid–Liquid Phase Separation in Alzheimer’s Disease: Mechanisms, Pathogenesis, and Therapeutic Implications

Tian, S., Liu, Y., Hong, H., & Li, S. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05280-y · Cited by 8 · see citing works

Implications of liquid-liquid phase separation and ferroptosis in Alzheimer's disease

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Proteins Associated with Neurodegenerative Diseases: Link to DNA Repair

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Dual roles of tannins as polyphenols and metal complexing agents in the prevention and treatment of Alzheimer's disease: Exploring the potential of dietary interventions

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Liquid–liquid phase separation in hepatocellular carcinoma

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Utilizing liquid-liquid biopolymer regulators to predict the prognosis and drug sensitivity of hepatocellular carcinoma

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Liquid-Liquid Phase Separation in the Prognosis of Lung Adenocarcinoma: An Integrated Analysis

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Targeting Liquid-Liquid Phase Separation and Autophagy in Alzheimer’s Disease: Insights into Molecular Mechanisms and Therapeutic Potential

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Membrane sensitization biosensor based on magnetic inducing for Tau protein detection

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Biomolecular phase separation of microtubule-associated protein tau and its role in the genesis of brain disorders

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Raman Dissection of Water-Interaction Coupling in Condensate-Relevant Peptides

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Phase Separation in Biological Systems: Implications for Disease Pathogenesis

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Mechanistic insights into cadmium-related premature aging in Drosophila model

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Prediction of liquid–liquid phase separation proteins based on protein language model

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Protein‐Independent Liquid–Liquid Phase Separation of Adenosine Triphosphate Under Crowded Conditions

Dec, R., Dzwolak, W., & Winter, R. (2026) · Chemistry - A European Journal · doi:10.1002/chem.71374 · Cited by 1 · see citing works

Crowding-Induced Liquid–Liquid Phase Separation in the ATP-Binding ACC 1–13 K 8 Peptide Leads to a Distinct Amyloid Variant

Dec, R., Dzwolak, W., & Winter, R. (2026) · Biomacromolecules · doi:10.1021/acs.biomac.5c02213 · Cited by 1 · see citing works

Photoreversible Aggregation of the Biliprotein Containing the First and Second GAF Domains of a Cyanobacteriochrome All2699 in Nostoc sp. PCC7120

Zhan, M.-L., Zhao, X., Li, X., Tan, Z., Xu, Q.-Z., Zhou, M., & Zhao, K. (2024) · Biochemistry · doi:10.1021/acs.biochem.4c00058

Role of Zn(II) in the aggregation of the 6aJL2R24G protein: Experimental and theoretical approach

Mata-Salgado, F., Morales-Ortiz, A., Millán‐Pacheco, C., Pastor, N., & Rivillas-Acevedo, L. A. (2025) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2025.113012

Liquid-liquid phase separation-related genes in the immune microenvironment and diagnosis of focal segmental glomerulosclerosis and minimal change disease

Lu, H., Sun, J., & Sun, J. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2573857

Liquid-liquid phase separation in physiological and pathophysiological bone turnover

Xia, Y., Xu, W., Yang, X., Huang, X., Xie, H., Yeung, K., Xie, Z., & Lan, Y. (2025) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjaf178

OptoChaperone─A Biohybrid Tool for Regulating Protein Condensates in Cells and In Vitro

Tuan, D. T., Matsusaki, M., Ota, H., Kawagoe, S., Nisansala, H. D., Kumashiro, M., Isozumi, N., Kumeta, H., Kono, Y., Shimi, T., et al. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c04074

AI-discovered protein fragments as generalizable regulators of biomolecular condensatesPreprint

Savinov, A., Sadasivan, J., White, K. J., Rubien, J. D., Li, G., & Case, L. B. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.08.723928 · Cited by 1 · see citing works

Helix-Aggregation Interplay in Nucleophosmin 1: Structural, Morphological, and Cytotoxic Consequences of Fragment Length

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20 Years of the ISCB Student Council Symposium: shaping computational biology and future leaders

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Multimodal Bioelectronics in Neuromodulation: Liquid Metals, Magnetoelectric, and High-Entropy Oxides

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Liquid-liquid phase separation in neurodegenerative diseases: Mechanisms, pathological transitions, and therapeutic opportunities

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Tau Liquid–Liquid Phase Separation in Alzheimer’s Disease: Mechanisms, Pathogenesis, and Therapeutic Implications

Tian, S., Liu, Y., Hong, H., & Li, S. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05280-y · Cited by 8 · see citing works

Liquid–liquid phase separation of tau in Alzheimer’s disease

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Tau liquid‐liquid phase separation in neurodegenerative diseases

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Liquid-liquid phase separation of protein tau: An emerging process in Alzheimer's disease pathogenesis

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Tau protein liquid–liquid phase separation can initiate tau aggregation

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