Cited by 345Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchPrion Diseases and Protein Misfolding

Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments

Barghorn, S., Mandelkow, E.·2002·Biochemistry

Abstract

Alzheimer's disease is characterized by aggregates of tau protein. Attempts to study the conditions for aggregation in vitro have led to different experimental systems, some of which appear mutually exclusive (e.g., oxidative vs reductive conditions, induction by polyanions vs fatty acids). We show here that different approaches and pathways can be viewed in a common framework, and that apparent differences can be explained by variations in the kinetics of subreactions. A unified view of PHF aggregation should help to analyze the causes of PHF aggregation and devise methods to prevent it.

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Crossref · 10.1021/bi026469j

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25 of 25 references verified0 citation errors · 0 not checkable

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  • K18 aggregates significantly faster than K19.

    “This protein aggregates significantly faster than K19, the corresponding three-repeat version (38, 39) (Fig. 1B).”

    From MAP2 caps tau fibrils and inhibits aggregation (2023) · cites this paper as [38]

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Authors
Barghorn, S., & Mandelkow, E.
Affiliations
  • Max Planck Unit for Structural Molecular Biology (DE)
  • Max-Planck-Unit for Structural Molecular Biology, Notkestrasse 85, 22607 Hamburg, Germany
Venue
Biochemistry
Published
2002-11-20
Volume
41
Issue
50
Pages
14885-14896
ISSN
  • 0006-2960 (ISSN-L)
  • 1520-4995
OpenAlex
W2006051211
Cited by
341
References
25
Citations by year
2026: 6 · 2025: 12 · 2024: 12 · 2023: 9 · 2022: 17 · 2021: 18 · 2020: 19 · 2019: 18 · 2018: 14 · 2017: 19 · 2016: 11 · 2015: 11 · 2014: 21 · 2013: 23 · 2012: 16
FWCI
8.79
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
Keywords
tau protein, paired helical filaments, Alzheimer's disease, protein aggregation, aggregation kinetics, oxidative conditions, reducing conditions, aggregation pathways
MeSH terms
Polyelectrolytes, Alzheimer Disease, Anions, Cross-Linking Reagents, Cysteine, Disulfides, Heparin, Humans, Polymers, Protein Processing, Post-Translational, Spectrometry, Fluorescence, Mutagenesis, Site-Directed, Arachidonic Acid, Neurofibrillary Tangles, tau Proteins, Protein Isoforms

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