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Cited by 87

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Intelligent Drug Delivery System Based on Mesoporous Silica Nanoparticles Coated with an Ultra-pH-Sensitive Gatekeeper and Poly(ethylene glycol)

Chen, Tianchan, Wu, Wei, Xiao, Hong, Chen, Yanxiao, Chen, Min, Li, Jianshu·2016·ACS Macro Letters
DOI 10.1021/acsmacrolett.5b00765
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Abstract

Mesoporous silica nanoparticles (MSNs) exhibit significant advantages for efficient drug/gene delivery but it is hard for simple MSNs to deliver the loaded drug to the target sites of disease. Considering that there are some well-known pH differences in the body, it is a useful strategy to modify the exterior surface of MSNs with stimuli-responsive gatekeepers to realize open-close transformation of their mesopores. In this work, multifunctional pH-sensitive MSNs were designed with mixed polymeric coatings, that is, poly(ethylene glycol) (PEG) as a dispersity-enhancer and poly(2-(pentamethyleneimino)ethyl methacrylate) (PPEMA) as an ultra-pH-sensitive gatekeeper. Enhanced dispersity, high drug loading capacity, long-circulation time, pH-triggered targeting, and better cellular uptake of the multifunctional MSNs make them potential candidates for pH-sensitive drug delivery such as tumor therapy.

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Crossref · 10.1021/acsmacrolett.5b00765

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Research works printed but not linked: 25

  1. 10.1039/c1jm10750j · DOI
  2. 10.1021/ja206998x · DOI
  3. 10.1002/smll.201201397 · DOI
  4. 10.1021/jp201053d · DOI
  5. 10.1021/cm3037197 · DOI · Paper page
  6. 10.1021/nn100918a · DOI
  7. 10.1002/ange.200501819 · DOI
  8. 10.1002/anie.200705211 · DOI
  9. 10.1016/j.biomaterials.2013.01.084 · DOI
  10. 10.1021/cm703363w · DOI
  11. 10.1021/la104973j · DOI
  12. 10.1021/jp103982a · DOI
  13. 10.1002/anie.201005061 · DOI
  14. 10.1021/am3005225 · DOI
  15. 10.1021/jp9043978 · DOI
  16. 10.1039/c1jm11869b · DOI
  17. 10.1002/anie.201300183 · DOI
  18. 10.1021/la4022646 · DOI
  19. 10.1166/jbn.2014.1846 · DOI
  20. 10.1039/C4RA05270F · DOI
  21. 10.1021/nl0479987 · DOI
  22. 10.1002/anie.201100884 · DOI
  23. 10.1016/j.micromeso.2008.08.004 · DOI
  24. 10.1021/jp208494w · DOI
  25. 10.1016/j.biomaterials.2011.11.045 · DOI

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Metadata

Authors
Chen, T., Wu, W., Xiao, H., Chen, Y., Chen, M., & Li, J.
Affiliations
  • Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory For Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030, China
  • Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, China
  • Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China
Venue
ACS Macro Letters
Publisher
American Chemical Society (ACS)
Published
2015-12-16
Volume
5
Issue
1
Pages
55-58
ISSN
2161-1653
DOI
10.1021/acsmacrolett.5b00765
Cited by
87
References
0
Language
en
Funders
  • National Natural Science Foundation of China (21534008, 51322303, 51573110)
  • State Key Laboratory of Polymer Materials Engineering, Sichuan University (sklpme2014-3-01)

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