CoChat
Sign Up
Cited by 170

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Bioresponsive Controlled Drug Release Based on Mesoporous Silica Nanoparticles Coated with Reductively Sheddable Polymer Shell

Chang, Baisong, Chen, Dan, Wang, Yang, Chen, Yanzuo, Jiao, Yunfeng, Sha, Xianyi, Yang, Wuli·2013·Chemistry of Materials
DOI 10.1021/cm3037197
Open this paper in CoChat — free account

Abstract

The design of bioresponsive controlled drug delivery systems is a promising approach in cancer therapy, but it still is a major challenge capable of optimum therapeutic efficacy, i.e. no premature drug leakage in blood circulation while having a rapid and complete release in tumor tissues. In this work, a kind of PEGylated core/shell structured composite nanoparticle was developed via precipitation polymerization, where a disulfide-cross-linked poly( N -vinylcaprolactam- co -methacrylic acid) (P(VCL- s - s -MAA)) polymer shell was created to act as sheddable thermo/pH-sensitive gatekeepers, and a carboxylic acid modified mesoporous silica nanoparticles (MSN-COOH) core was applicable as an accessible reservoir to encapsulate high drug doses. At physiological conditions, the P(VCL- s - s -MAA)-PEG shell underwent a distinct transition from a swollen state in pH 7.4 to a collapsed state in pH 5.0. Though sufficiently stable in water, composite nanoparticles were prone to fast dissociation and rupture when subjecting to 10 mM glutathione (GSH), due to the shedding of polymer walls through reductive cleavage of intermediate disulfide bonds, so that the polymer shell was active in moderating the diffusion of embedded drugs in-and-out of MSN channels. The cumulative in vitro release of DOX-loaded composite nanoparticles allowed a low trace of DOX diffusion below volume phase transition temperature (VPTT) and a significant release rate above its VPTT, while the most rapid and perfect…

Overview

Integrity signals

Registry

Crossref · 10.1021/cm3037197

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 2 references

Research works printed but not linked: 61

  1. Schmaljohann D., 2006, Adv. Drug Delivery Rev., 58, 1655, 10.1016/j.addr.2006.09.020 · DOI · Paper page
  2. Yiu H. H. P., 2010, Adv. Funct. Mater., 20, 1599, 10.1002/adfm.200902117 · DOI
  3. Such G. K., 2011, Chem. Soc. Rev., 40, 19, 10.1039/C0CS00001A · DOI
  4. Poon Z., 2011, ACS Nano, 5, 4284, 10.1021/nn200876f · DOI · Paper page
  5. Trewyn B. G., 2007, Acc. Chem. Res., 40, 846, 10.1021/ar600032u · DOI
  6. Lu J., 2010, Small, 6, 1794, 10.1002/smll.201000538 · DOI
  7. Yamada H., 2012, Chem. Mater., 24, 1462, 10.1021/cm3001688 · DOI
  8. Wang Y. J., 2005, Chem. Mater., 17, 953, 10.1021/cm0483137 · DOI
  9. Wang Y. J., 2010, Adv. Mater., 22, 4293, 10.1002/adma.201001497 · DOI
  10. Slowing I. I., 2008, Adv. Drug Delivery Rev., 60, 1278, 10.1016/j.addr.2008.03.012 · DOI
  11. Li Z. X., 2012, Chem. Soc. Rev., 41, 2590, 10.1039/c1cs15246g · DOI
  12. Luo Z., 2011, Angew. Chem., Int. Ed., 50, 640, 10.1002/anie.201005061 · DOI
  13. Chen C. E., 2011, Angew. Chem., Int. Ed., 50, 882, 10.1002/anie.201005471 · DOI
  14. Lai C. Y., 2003, J. Am. Chem. Soc., 125, 4451, 10.1021/ja028650l · DOI
  15. Giri S., 2005, Angew. Chem., Int. Ed., 44, 5038, 10.1002/anie.200501819 · DOI
  16. Slowing I. I., 2010, J. Mater. Chem., 20, 7924, 10.1039/c0jm00554a · DOI
  17. Meng F. H., 2009, Biomaterials, 30, 2180, 10.1016/j.biomaterials.2009.01.026 · DOI
  18. Yang Y., 2008, J. Mater. Chem., 18, 5731, 10.1039/b811573g · DOI
  19. Singh N., 2011, J. Am. Chem. Soc., 133, 19582, 10.1021/ja206998x · DOI
  20. Bhattacharyya S., 2012, Acta Biomater., 8, 3429, 10.1016/j.actbio.2012.06.003 · DOI
  21. Feng P. Y., 2011, Langmuir, 27, 3095, 10.1021/la104973j · DOI
  22. Chang B. S., 2011, J. Mater. Chem., 21, 9239, 10.1039/c1jm10631g · DOI
  23. Lee J. E., 2010, J. Am. Chem. Soc., 132, 552, 10.1021/ja905793q · DOI
  24. Lang N., 2004, Chem. Mater., 16, 1961, 10.1021/cm030633n · DOI
  25. Chang B. S., 2010, J. Mater. Chem., 20, 9941, 10.1039/c0jm01237h · DOI
  26. Karg M., 2006, ChemPhysChem, 7, 2298, 10.1002/cphc.200600483 · DOI
  27. Vihola H., 2005, Biomaterials, 26, 3055, 10.1016/j.biomaterials.2004.09.008 · DOI · Paper page
  28. Gong J. L., 2011, Chem. Commun., 47, 3442, 10.1039/c0cc05520d · DOI
  29. Lapeyre V., 2009, Langmuir, 25, 4659, 10.1021/la9003438 · DOI
  30. Moller K., 2007, Adv. Funct. Mater., 17, 605, 10.1002/adfm.200600578 · DOI
  31. Kozanoglu S., 2011, J. Macromol. Sci., Part A: Pure Appl. Chem., 48, 467, 10.1080/10601325.2011.573350 · DOI
  32. Shah S., 2010, Eur. Polym. J., 46, 958, 10.1016/j.eurpolymj.2010.01.005 · DOI
  33. You Y. Z., 2008, Chem. Mater., 20, 3354, 10.1021/cm703363w · DOI
  34. Yang Q., 2005, Chem. Mater., 17, 5999, 10.1021/cm051198v · DOI
  35. Imaz A., 2011, J. Polym. Sci., Part A: Polym. Chem., 49, 3218, 10.1002/pola.24758 · DOI
  36. Liu J. S., 2006, J. Membr. Sci., 283, 190, 10.1016/j.memsci.2006.06.027 · DOI
  37. Kobler J., 2008, ACS Nano, 2, 791, 10.1021/nn700008s · DOI
  38. Wu K. C. W., 2011, J. Phys. Chem. C, 115, 13158
  39. Kecht J., 2008, Chem. Mater., 20, 7207, 10.1021/cm801484r · DOI
  40. Nayak S., 2005, Angew. Chem., Int. Ed., 44, 7686, 10.1002/anie.200501321 · DOI
  41. Saunders B. R., 2009, Adv. Colloid Interface Sci., 147, 251, 10.1016/j.cis.2008.08.008 · DOI
  42. Ono Y., 2006, J. Am. Chem. Soc., 128, 10030, 10.1021/ja063990i · DOI
  43. Shibayama M., 1996, J. Chem. Phys., 105, 4358, 10.1063/1.472252 · DOI
  44. Jones C. D., 2000, Macromolecules, 33, 8301, 10.1021/ma001398m · DOI
  45. Zhou S. Q., 1998, J. Phys. Chem. B, 102, 1364, 10.1021/jp972990p · DOI
  46. Imaz A., 2009, Eur. Polym. J., 45, 3164, 10.1016/j.eurpolymj.2009.08.003 · DOI
  47. Kerker M., 1969, The scattering of light and other electromagnetic radiation
  48. Duracher D., 1999, J. Polym. Sci., Part A: Polym. Chem., 37, 1823, 10.1002/(SICI)1099-0518(19990615)37:12<1823::AID-POLA12>3.0.CO;2-# · DOI
  49. Vivero-Escoto J. L., 2010, Small, 6, 1952, 10.1002/smll.200901789 · DOI
  50. Xu H. F., 2009, J. Mater. Chem., 19, 4183, 10.1039/b901141b · DOI
  51. Shimoni O., 2012, ACS Nano, 6, 1463, 10.1021/nn204319b · DOI
  52. Duncan R., 2003, Nat. Rev. Drug Discovery, 2, 347, 10.1038/nrd1088 · DOI
  53. Barenholz Y., 1993, Med. Res. Rev., 13, 449, 10.1002/med.2610130404 · DOI
  54. Choucair A., 2005, Langmuir, 21, 9308, 10.1021/la050710o · DOI
  55. Hoare T., 2008, Langmuir, 24, 1005, 10.1021/la7024507 · DOI
  56. Karg M., 2009, J. Mater. Chem., 19, 8714, 10.1039/b820292n · DOI
  57. Yan E. Y., 2009, Chem. Commun., 45, 2718, 10.1039/b900751b · DOI
  58. Zhang Q., 2012, Adv. Funct. Mater., 22, 5144, 10.1002/adfm.201201316 · DOI
  59. Gaulding J. C., 2012, Macromolecules, 45, 39, 10.1021/ma202282p · DOI
  60. Li Y. L., 2009, Angew. Chem., Int. Ed., 48, 9914, 10.1002/anie.200904260 · DOI
  61. Cui J. W., 2012, Adv. Funct. Mater., 22, 4718, 10.1002/adfm.201201191 · DOI

Cited by

Sorted by citations

See all 170

Metadata

Authors
Chang, B., Chen, D., Wang, Y., Chen, Y., Jiao, Y., Sha, X., & Yang, W.
Affiliations
  • State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, No. 220 Handan Road, Shanghai 200433, China
  • Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education & PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, China
Venue
Chemistry of Materials
Publisher
American Chemical Society (ACS)
Published
2013-02-12
Volume
25
Issue
4
Pages
574-585
ISSN
  • 0897-4756
  • 1520-5002
DOI
10.1021/cm3037197
Cited by
170
References
2
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review