The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Cancer-Erythrocyte Hybrid Membrane-Camouflaged Magnetic Nanoparticles with Enhanced Photothermal-Immunotherapy for Ovarian Cancer
Abstract
Cell-membrane-coated nanoparticles are widely studied due to their inherent cellular properties, such as immune escape and homologous homing. A cell membrane coating can also maintain the relative stability of nanoparticles during circulation in a complex blood environment through cell membrane encapsulation technology. In this study, we fused a murine-derived ID8 ovarian cancer cell membrane with a red blood cell (RBC) membrane to create a hybrid biomimetic coating (IRM), and hybrid IRM camouflaged indocyanine green (ICG)-loaded magnetic nanoparticles (Fe 3 O 4 -ICG@IRM) were fabricated for combination therapy of ovarian cancer. Fe 3 O 4 -ICG@IRM retained both ID8 and RBC cell membrane proteins and exhibited highly specific self-recognition of ID8 cells in vitro and in vivo as well as a prolonged circulation lifetime in blood. Interestingly, in the bilateral flank tumor model, the IRM-coated nanoparticles also activated specific immunity, which killed homologous ID8 tumor cells but had no effect on B16-F10 tumor cells. Furthermore, Fe 3 O 4 -ICG@IRM showed synergistic photothermal therapy, resulting in the release of whole-cell tumor antigens by photothermal-induced tumor necrosis, which further enhanced antitumor immunotherapy for primary tumor and metastatic tumor by activating CD8 + cytotoxic T cells and reducing regulatory Foxp3 + T cells. Together, the biomimetic Fe 3 O 4 -ICG@IRM nanoparticles showed synergistic photothermal-immunotherapy for ovarian cancer.
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Cites
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Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Lu, Q., Kou, D., Lou, S., Ashrafizadeh, M., Aref, A. R., Canadas, I., Tian, Y., Niu, X., Wang, Y., Torabian, P., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01535-8 · Cited by 373
Cell membrane-coated nanoparticles: a novel multifunctional biomimetic drug delivery system
Liu, H., Su, Y.-Y., Jiang, X.-C., & Gao, J.-Q. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01252-0 · Cited by 302
Zhang, M., Liu, C., Tu, J., Tang, M., Ashrafizadeh, M., Nabavi, N., Sethi, G., Zhao, P., & Liu, S. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02305-x · Cited by 259
Domingues, C., Santos, A., Alvarez-Lorenzo, C., Concheiro, A., Jarak, I., Veiga, F., Barbosa, I., Dourado, M., & Figueiras, A. (2022) · ACS Nano · doi:10.1021/acsnano.2c00128 · Cited by 235
Cui, Y., Lv, B., Li, Z., Ma, C., Gui, Z., Geng, Y., Liu, G., Sang, L., Xu, C., Min, Q., et al. (2024) · Small · doi:10.1002/smll.202303494 · Cited by 81
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Metadata
- Authors
- Xiong, J., Wu, M., Chen, J., Liu, Y., Chen, Y., Fan, G., Liu, Y., Cheng, J., Wang, Z., Wang, S., Liu, Y., & Zhang, W.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-12-03
- Volume
- 15
- Issue
- 12
- Pages
- 19756-19770
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W3217799976
- Cited by
- 266
- References
- 41
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- closed
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