The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu2MoS4 for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy
Abstract
The unique tumor microenvironment (TME) facilitates cancer proliferation and metastasis, and it is hard to cure cancer completely via monotherapy. Herein, a multifunctional cascade bioreactor based on hollow mesoporous Cu 2 MoS 4 (CMS) loaded with glucose oxidase (GOx) is constructed for synergetic cancer therapy by chemo‐dynamic therapy (CDT)/starvation therapy/phototherapy/immunotherapy. The CMS harboring multivalent elements (Cu 1+/2+, Mo 4+/6+) exhibit Fenton‐like, glutathione (GSH) peroxidase‐like and catalase‐like activity. Once internalized into the tumor, CMS could generate ·OH for CDT via Fenton‐like reaction and deplete overexpressed GSH in TME to alleviate antioxidant capability of the tumors. Moreover, under hypoxia TME, the catalase‐like CMS could react with endogenous H 2 O 2 to generate O 2 for activating the catalyzed oxidation of glucose by GOx for starvation therapy accompanied with the regeneration of H 2 O 2. The regenerated H 2 O 2 can devote to Fenton‐like reaction for realizing GOx‐catalysis‐enhanced CDT. Meanwhile, the CMS under 1064 nm laser irradiation shows remarkable tumor‐killing ability by phototherapy due to its excellent photothermal conversion efficiency (η = 63.3%) and cytotoxic superoxide anion (·O 2−) generation performance. More importantly, the PEGylated CMS@GOx‐based synergistic therapy combined with checkpoint blockade therapy could elicit robust immune responses for both effectively ablating primary tumors and inhibiting cancer metastasis.
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Cited by
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Theranostic Fluorescent Probes
Sharma, A., Verwilst, P., Li, M., Ma, D., Singh, N., Yoo, J., Kim, Y., Yang, Y., Zhu, J.-H., Huang, H., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00778 · Cited by 499
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Metadata
- Authors
- Chang, M., Wang, M., Wang, M., Shu, M., Ding, B., Li, C., Pang, M., Cui, S., Hou, Z., & Lin, J.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2019-11-04
- Volume
- 31
- Issue
- 51
- Pages
- e1905271-e1905271
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2985055119
- Cited by
- 484
- References
- 45
- FWCI
- 23.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chang, M., Wang, M., Wang, M., Shu, M., Ding, B., Li, C., Pang, M., Cui, S., Hou, Z., & Lin, J. (2019). A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu2MoS4 for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy. Advanced Materials. https://doi.org/10.1002/adma.201905271
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