The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles
Open accessAbstract
Summary Calcium overload, characterized by an abnormal cytoplasm accumulation of free calcium ions (Ca2+), is a widely recognized cause of damage in numerous cell types and even of cell death. This undesirable destructive process can become a new tool applicable to cancer treatment. Herein, on the basis of the unique biological effect of Ca2+, we demonstrate a highly efficient strategy for tumor therapy by utilizing pH-sensitive sodium-hyaluronate-modified calcium peroxide nanoparticles (SH-CaO2 NPs). These NPs create an artificial calcium overloading stress in tumor cells, which is responsible for cell death. Notably, the killing effect is not limited to tumor types or hypoxic cells, and normal cells are more tolerant of the adverse influence of NPs than tumor cells. The Ca2+ enrichment also increases the likelihood of tumor calcification, which could contribute to in vivo tumor inhibition and facilitate medical imaging to monitor the treatment efficacy.
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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Calcium, ATP, and ROS: a mitochondrial love-hate triangle
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Calcium and ROS: A mutual interplay
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Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
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Cited by
Fu, L., Wan, Y., Qi, C., He, J., Li, C., Yang, C., Xu, H., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202006892 · Cited by 820
Zheng, P., Ding, B., Jiang, Z., Xu, W., Li, G., Ding, J., & Chen, X. (2021) · Nano Letters · doi:10.1021/acs.nanolett.0c04778 · Cited by 359
Cui, H., Liu, M., Yu, W., Cao, Y., Zhou, H., Yin, J., Liu, H., Que, S., Wang, J., Huang, C., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c07409 · Cited by 116
Metal peroxides for cancer treatment
He, J., Fu, L.-H., Qi, C., Lin, J., & Huang, P. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.01.026 · Cited by 93
Li, S., Qin, S., Zeng, H., Chou, W., Oudin, A., Kanninen, K. M., Jalava, P., Dong, G., & Zeng, X. (2024) · Eco-Environment & Health · doi:10.1016/j.eehl.2024.08.002 · Cited by 54
Metadata
- Authors
- Zhang, M., Song, R., Liu, Y., Yi, Z., Meng, X., Zhang, J., Tang, Z., Yao, Z., Liu, Y., Liu, X., & Bu, W.
- Venue
- Chem
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 5
- Issue
- 8
- Pages
- 2171-2182
- ISSN
- 2451-9294 (ISSN-L)
- OpenAlex
- W2954904043
- Cited by
- 527
- References
- 5
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhang, M., Song, R., Liu, Y., Yi, Z., Meng, X., Zhang, J., Tang, Z., Yao, Z., Liu, Y., Liu, X., & Bu, W. (2019). Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles. Chem. https://doi.org/10.1016/j.chempr.2019.06.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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