A Multifunctional Layered Nickel Silicate Nanogenerator of Synchronous Oxygen Self-supply and Superoxide Radical Generation for Hypoxic Tumor Therapy

Huang, Xiaoyu; Zhang, Wei; Peng, Yaowei; Gao, Lu; Wang, Fu; Wang, Lan; Wei, Xunbin

doi:10.1021/acsnano.1c08580

Cited by 46Nanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced Photocatalysis Techniques

A Multifunctional Layered Nickel Silicate Nanogenerator of Synchronous Oxygen Self-supply and Superoxide Radical Generation for Hypoxic Tumor Therapy

Huang, Xiaoyu, Zhang, Wei, Peng, Yaowei, Gao, Lu, Wang, Fu, Wang, Lan, Wei, Xunbin·2022·ACS Nano

DOI 10.1021/acsnano.1c08580

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Abstract

Oxygen consumption but hypoxic tumor environment has been considered as the major obstacle in photodynamic therapy. Although oxygen-supplied strategies have been reported extensively, they still suffer from the complicated system and unsatisfied PDT efficiency. Herein, one-component layered nickel silicate nanoplatforms (LNS NPs) are successfully synthesized using natural vermiculite as the silica source, which can simultaneously supply oxygen (O 2 ) and generate superoxide radicals (O 2 –• ) under near-infrared irradiation. The appropriate electron band structure endows LNS NPs with attractive optical properties, where the bandgap edges determine the performance of redox activity and spectral response characteristic. Evidenced by both in vitro and in vivo investigations, LNS NPs can generate sufficient superoxide radicals under 660 nm laser irradiation to induce tumor cell apoptosis even in a severe hypoxic environment, which benefits from self-supplied oxygen. Besides, the photoacoustic oxy-hem imaging and histologic assay further demonstrated that the generated oxygen can relieve the inherent intratumoral hypoxia. Therefore, LNS NPs not only serve as superoxide radical generator but also produce oxygen to modulate hypoxia, suggesting that it can be used for superoxide radical-mediated photodynamic therapy with enhanced antitumor effect.

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Nanoparticles can generate superoxide radicals while splitting water to produce oxygen, which can promote photodynamic therapy against tumors.
“Recently, several studies have shown that nanoparticles can also generate superoxide radicals while splitting water to produce oxygen, which can promote photodynamic therapy against tumors. 443 , 444 , 445 , 446”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [443]

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Hypoxia signaling in cancer: Implications for therapeutic interventions
Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119 · see citing works

Authors: Huang, X., Zhang, W., Peng, Y., Gao, L., Wang, F., Wang, L., & Wei, X.
Affiliations: Shanghai Jiao Tong University (CN)
Shaanxi University of Science and Technology (CN)
Peking University (CN)
Corresponding author: Wang, Fu
Wang, Lan
Wei, Xunbin
ORCID: Huang, Xiaoyu
Gao, Lu
Wang, Fu
Wang, Lan
Wei, Xunbin
Venue: ACS Nano
Publisher: American Chemical Society (ACS)
Published: 2021-12-28
Volume: 16
Issue: 1
Pages: 974-983
ISSN: 1936-0851 (ISSN-L)
1936-086X
DOI: 10.1021/acsnano.1c08580
OpenAlex: W4200561498
Cited by: 46
References: 56
Citations by year: 2026: 9 · 2025: 7 · 2024: 10 · 2023: 12 · 2022: 8
FWCI: 2.28
Type: journal article
Language: en
Open access: closed
Licence: doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-045 (stm-asf)
Locations: ACS Nano (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (22076114)
the National Key Research and Development Program of China (2019YFC1604604)
Guangdong Provincial Key Laboratory of Biomedical Optical Imaging Technology (2020B121201010)
Shenzhen Science and Technology Innovation grants (JCYJ20200109115633343)
Key Research and Development Program of Shaanxi (2021SF-452)
the Special Fund for Research on National Major Research Instruments of China (Grant No. 62027824)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Advanced Photocatalysis Techniques
Keywords: oxygen self-supply, superoxide production, photodynamic therapy, tumor hypoxia, near-infrared irradiation, photoacoustic imaging, tumor oxygenation, apoptosis, anticancer activity
MeSH terms: Hypoxia, Humans, Nickel, Oxygen, Photochemotherapy, Superoxides, Photosensitizing Agents, Silicates, Cell Line, Tumor, Nanoparticles

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A Multifunctional Layered Nickel Silicate Nanogenerator of Synchronous Oxygen Self-supply and Superoxide Radical Generation for Hypoxic Tumor Therapy

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