Intrinsic Radical Species Scavenging Activities of Tea Polyphenols Nanoparticles Block Pyroptosis in Endotoxin-Induced Sepsis

Chen, Yuan; Luo, Ruiheng; Li, Jing; Wang, Shengfeng; Ding, Jinsong; Zhao, Kai; Lu, Ben; Zhou, Wenhu

doi:10.1021/acsnano.1c08913

Intrinsic Radical Species Scavenging Activities of Tea Polyphenols Nanoparticles Block Pyroptosis in Endotoxin-Induced Sepsis

Sepsis, a life-threating illness caused by deregulated host immune responses to infections, is characterized by overproduction of multiple reactive oxygen and nitrogen species (RONS) and excessive pyroptosis, leading to high mortality. However, there is still no approved specific molecular therap…