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Cited by 104Advanced Nanomaterials in CatalysisNanoparticle-Based Drug DeliveryNeuroprotection in Cerebral Ischemia

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Bioactive Ceria Nanoenzymes Target Mitochondria in Reperfusion Injury to Treat Ischemic Stroke

Liao, Jun, Li, Yi, Fan, Li, Sun, Yuhan, Gu, Zhengyan, Xu, Qing-Qiang, Wang, Yun, Xiong, Liyan, Xiao, Kai, Chen, Zhe-sheng, Ma, Zhiwei, Zhang, Chuan, Wang, Tingfang, Lu, Ying·2024·ACS Nano
DOI 10.1021/acsnano.3c10982
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Abstract

Overproduction of reactive oxygen species by damaged mitochondria after ischemia is a key factor in the subsequent cascade of damage. Delivery of therapeutic agents to the mitochondria of damaged neurons in the brain is a potentially promising targeted therapeutic strategy for the treatment of ischemic stroke. In this study, we developed a ceria nanoenzymes synergistic drug-carrying nanosystem targeting mitochondria to address multiple factors of ischemic stroke. Each component of this nanosystem works individually as well as synergistically, resulting in a comprehensive therapy. Alleviation of oxidative stress and modulation of the mitochondrial microenvironment into a favorable state for ischemic tolerance are combined to restore the ischemic microenvironment by bridging mitochondrial and multiple injuries. This work also revealed the detailed mechanisms by which the proposed nanodelivery system protects the brain, which represents a paradigm shift in ischemic stroke treatment.

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Crossref · 10.1021/acsnano.3c10982

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1 of 1 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 57

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Metadata

Authors
Liao, J., Li, Y., Fan, L., Sun, Y., Gu, Z., Xu, Q.-Q., Wang, Y., Xiong, L., Xiao, K., Chen, Z.-S., Ma, Z., Zhang, C., Wang, T., & Lu, Y.
Affiliations
  • Shanghai University (CN)
  • Second Military Medical University (CN)
  • St. John's University (US)
  • ShanghaiTech University (CN)
  • Department of Pharmaceutical Sciences, School of Pharmacy, Naval Medical University, Shanghai, 200433, China
Corresponding author
  • Ma, Zhiwei
  • Zhang, Chuan
  • Wang, Tingfang
ORCID
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2024-01-24
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
DOI
10.1021/acsnano.3c10982
OpenAlex
W4391160872
Cited by
104
References
1
Citations by year
2026: 28 · 2025: 51 · 2024: 25
FWCI
9.30
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • ACS Nano (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Science Foundation of Shanghai Municipality (20ZR1420000, 20ZR1470300)
  • Science and Technology Innovation Plan Of Shanghai Science and Technology Commission (21S21902100)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Advanced Nanomaterials in Catalysis
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords
ischemic stroke, ischemia-reperfusion injury, mitochondrial targeting, reactive oxygen species, oxidative stress, ischemic tolerance, neuroprotection, synergistic therapy

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