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Organ-Specific and Size-Dependent Ag Nanoparticle Toxicity in Gills and Intestines of Adult Zebrafish
Abstract
We studied adult zebrafish to determine whether the size of 20 and 110 nm citrate-coated silver nanoparticles (AgC NPs) differentially impact the gills and intestines, known target organs for Ag toxicity in fish. Following exposure for 4 h, 4 days, or 4 days plus a 7 day depuration period, we obtained different toxicokinetic profiles for different particle sizes, as determined by Ag content of the tissues. Ionic AgNO3 served as a positive control. The gills showed a significantly higher Ag content for the 20 nm particles at 4 h and 4 days than the 110 nm particles, while the values were more similar in the intestines. Both particle types were retained in the intestines even after depuration. These toxicokinetics were accompanied by striking size-dependent differences in the ultrastructural features and histopathology in the target organs in response to the particulates. Ag staining of the gills and intestines confirmed prominent Ag deposition in the basolateral membranes for the 20 nm but not for the 110 nm particles. Furthermore, it was possible to link the site of tissue deposition to disruption of the Na(+)/K(+) ion channel, which is also localized to the basolateral membrane. This was confirmed by a reduction in ATPase activity and immunohistochemical detection of the α subunit of this channel in both target organs, with the 20 nm particles causing significantly higher inhibition and disruption than the larger size particles or AgNO3. These results demonstrate the importance of particle size in determining the hazardous impact of AgNPs in the gills and intestines of adult zebrafish.
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In exposed fish, intestines demonstrated similar concentrations of both 20 nm and 120 nm diameter particles, with intestinal particulate materials at parity following a seven-day depuration period.
“Analysis of the intestines demonstrated similar concentrations of both 20 nm and 120 nm diameter particles in exposed fish, with intestinal particulate materials at parity for fish following a seven-day depuration period [92].”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [92]
Toxicity of silver nanoparticles in zebrafish demonstrates a size dependent reaction, with 20 nm particles occurring in significantly higher concentrations in the gills than 120 nm particles.
“The research undertaken on the toxicity of silver nanoparticles in zebrafish demonstrate a size dependent reaction, with finer particulate matter (20 nm) occurring in significantly higher concentrations in the gills than larger particulate matter (120 nm) [92].”
From Nanoparticles in Construction Materials and Other Applications, and Implications of Nanoparticle Use (2019) · cites this paper as [92]
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Metadata
- Authors
- Osborne, O. J., Lin, S., Chang, C. H., Ji, Z., Yu, X., Wang, X., Lin, S., Xia, T., & Nel, A. E.
- Affiliations
- California NanoSystems Institute (US)
- Corresponding author
- Nel, André E.
- ORCID
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-09-09
- Volume
- 9
- Issue
- 10
- Pages
- 9573-9584
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2255558944
- Cited by
- 196
- References
- 43
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 12 · 2023: 15 · 2022: 17 · 2021: 22 · 2020: 26 · 2019: 27 · 2018: 25 · 2017: 24 · 2016: 10 · 2015: 1
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Environmental Protection Agency (DBI 1266377)
- National Science Foundation (DBI 1266377)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Keywords
- silver nanoparticles, particle size effects, nanoparticle toxicity, zebrafish, gill, intestine, toxicokinetics, silver deposition, basolateral membrane, Na+/K+-ATPase inhibition, depuration, histopathology, silver nitrate
- MeSH terms
- Sodium-Potassium-Exchanging ATPase, Animals, Anti-Infective Agents, Female, Gills, Intestines, Male, Particle Size, Silver, Water Pollutants, Chemical, Zebrafish, Metal Nanoparticles
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