Cited by 113Nanotechnology research and applicationsNeurogenesis and neuroplasticity mechanismsNeuroscience and Neural Engineering

Nanomaterials in Neural‐Stem‐Cell‐Mediated Regenerative Medicine: Imaging and Treatment of Neurological Diseases

Zhang, Bingbo, Yan, Wei, Zhu, Yanjing, Yang, Weitao, Le, Wenjun, Chen, Bingdi, Zhu, Rongrong, Cheng, Liming·2018·Advanced Materials

Abstract

Patients are increasingly being diagnosed with neuropathic diseases, but are rarely cured because of the loss of neurons in damaged tissues. This situation creates an urgent clinical need to develop alternative treatment strategies for effective repair and regeneration of injured or diseased tissues. Neural stem cells (NSCs), highly pluripotent cells with the ability of self‐renewal and potential for multidirectional differentiation, provide a promising solution to meet this demand. However, some serious challenges remaining to be addressed are the regulation of implanted NSCs, tracking their fate, monitoring their interaction with and responsiveness to the tissue environment, and evaluating their treatment efficacy. Nanomaterials have been envisioned as innovative components to further empower the field of NSC‐based regenerative medicine, because their unique physicochemical characteristics provide unparalleled solutions to the imaging and treatment of diseases. By building on the advantages of nanomaterials, tremendous efforts have been devoted to facilitate research into the clinical translation of NSC‐based therapy. Here, recent work on emerging nanomaterials is highlighted and their performance in the imaging and treatment of neurological diseases is evaluated, comparing the strengths and weaknesses of various imaging modalities currently used. The underlying mechanisms of therapeutic efficacy are discussed, and future research directions are suggested.

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Crossref · 10.1002/adma.201705694

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  • Radiolabelled nanoparticles illuminate molecular processes in vivo with unparalleled resolution.

    “The synergy of radiolabelling techniques with nanoparticle formulations amplifies their diagnostic potential, as radionuclide-bearing nanoparticles illuminate molecular processes in vivo with unparalleled resolution [80].”

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Authors
Zhang, B., Yan, W., Zhu, Y., Yang, W., Le, W., Chen, B., Zhu, R., & Cheng, L.
Affiliations
  • Tongji University (CN)
  • Ministry of Education of the People's Republic of China (CN)
Corresponding author
  • Chen, Bingdi
  • Zhu, Rongrong
  • Cheng, Liming
Venue
Advanced Materials
Publisher
Wiley
Published
2018-03-15
Volume
30
Issue
17
Pages
e1705694-e1705694
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
OpenAlex
W2793591222
Cited by
113
References
271
Citations by year
2026: 9 · 2025: 15 · 2024: 8 · 2023: 20 · 2022: 19 · 2021: 17 · 2020: 15 · 2019: 8 · 2018: 1
FWCI
0.83
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81571742, 81671105, 81772285)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanotechnology research and applications
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Keywords
nanomaterials, neural stem cells, regenerative medicine, neurological disorders, stem cell tracking, stem cell imaging, stem cell therapy, clinical translation, neurodegeneration, cell fate regulation, therapeutic mechanisms
MeSH terms
Cell Differentiation, Humans, Neurons, Regenerative Medicine, Nanostructures, Neural Stem Cells

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