Nanomaterials in Neural‐Stem‐Cell‐Mediated Regenerative Medicine: Imaging and Treatment of Neurological Diseases
Abstract
Patients are increasingly being diagnosed with neuropathic diseases, but are rarely cured because of the loss of neurons in damaged tissues. This situation creates an urgent clinical need to develop alternative treatment strategies for effective repair and regeneration of injured or diseased tissues. Neural stem cells (NSCs), highly pluripotent cells with the ability of self‐renewal and potential for multidirectional differentiation, provide a promising solution to meet this demand. However, some serious challenges remaining to be addressed are the regulation of implanted NSCs, tracking their fate, monitoring their interaction with and responsiveness to the tissue environment, and evaluating their treatment efficacy. Nanomaterials have been envisioned as innovative components to further empower the field of NSC‐based regenerative medicine, because their unique physicochemical characteristics provide unparalleled solutions to the imaging and treatment of diseases. By building on the advantages of nanomaterials, tremendous efforts have been devoted to facilitate research into the clinical translation of NSC‐based therapy. Here, recent work on emerging nanomaterials is highlighted and their performance in the imaging and treatment of neurological diseases is evaluated, comparing the strengths and weaknesses of various imaging modalities currently used. The underlying mechanisms of therapeutic efficacy are discussed, and future research directions are suggested.
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Radiolabelled nanoparticles illuminate molecular processes in vivo with unparalleled resolution.
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From Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation (2024) · cites this paper as [80]
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Wang, Y., Zhang, X., Yao, L., Yan, Y., Wang, Y., & Wu, T. S. (2025) · Nanoscale Horizons · doi:10.1039/d5nh00295h · Cited by 2 · see citing works
Novel Therapeutics and Diagnostics Strategies Based on Engineered Nanobiomaterials
Karmakar, S., Saxena, V., Chandra, P., & Pandey, L. M. (2019) · Springer eBooks · doi:10.1007/978-981-13-6004-6_1 · Cited by 2 · see citing works
The application of magnetic therapy in stroke treatment: Traditional treatment and biomaterials
Fan, Y., Zhang, X., Zhang, L., Han, X., Zhao, H., Zhong, Y., Jiang, X., Wei, Y., Pi, Y., Wang, Y., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.172060 · Cited by 1 · see citing works
Development of Nanomaterials from Natural Resources for Biosensing and Biomedical Technology
Matmin, J., Zainal-Abidin, M. H., Malek, N. A. N. N., & Wahab, R. A. (2023) · Springer eBooks · doi:10.1007/978-981-99-2267-3_12 · Cited by 1 · see citing works
The effects of self-assembling peptide on glial cell activation
Hajinejad, M., Far, B. F., Gorji, A., & Negah, S. S. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03415-x · Cited by 1 · see citing works
Zhou, M., & Han, B. (2021) · Science of Advanced Materials · doi:10.1166/sam.2021.4023 · Cited by 1 · see citing works
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Monte Carlo calculations for a fusion reactor blanket and shield
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- Authors
- Zhang, B., Yan, W., Zhu, Y., Yang, W., Le, W., Chen, B., Zhu, R., & Cheng, L.
- Affiliations
- Tongji University (CN)
- Ministry of Education of the People's Republic of China (CN)
- Corresponding author
- Chen, Bingdi
- Zhu, Rongrong
- Cheng, Liming
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-03-15
- Volume
- 30
- Issue
- 17
- Pages
- e1705694-e1705694
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2793591222
- Cited by
- 113
- References
- 271
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 8 · 2023: 20 · 2022: 19 · 2021: 17 · 2020: 15 · 2019: 8 · 2018: 1
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81571742, 81671105, 81772285)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanotechnology research and applications
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- nanomaterials, neural stem cells, regenerative medicine, neurological disorders, stem cell tracking, stem cell imaging, stem cell therapy, clinical translation, neurodegeneration, cell fate regulation, therapeutic mechanisms
- MeSH terms
- Cell Differentiation, Humans, Neurons, Regenerative Medicine, Nanostructures, Neural Stem Cells
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