The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Tobacco Mosaic Virus Delivery of Phenanthriplatin for Cancer therapy
Open accessAbstract
Phenanthriplatin, cis-[Pt(NH3)2Cl(phenanthridine)](NO3), is a cationic monofunctional DNA-binding platinum(II) anticancer drug candidate with unusual potency and cellular response profiles. Its in vivo efficacy has not yet been demonstrated, highlighting the need for a delivery system. Here we report tobacco mosaic virus (TMV) as a delivery system for phenanthriplatin. TMV forms hollow nanotubes with a polyanionic interior surface; capitalizing on this native structure, we developed a one-step phenanthriplatin loading protocol. Phenanthriplatin release from the carrier is induced in acidic environments. This delivery system, designated PhenPt-TMV, exhibits matched efficacy in a cancer cell panel compared to free phenanthriplatin. In vivo tumor delivery and efficacy were confirmed by using a mouse model of triple negative breast cancer. Tumors treated with PhenPt-TMV were 4× smaller than tumors treated with free phenanthriplatin or cisplatin, owing to increased accumulation of phenanthriplatin within the tumor tissue. The biology-derived TMV delivery system may facilitate translation of phenanthriplatin into the clinic.
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Tumour‐associated macrophages act as a slow‐release reservoir of nano‐therapeutic Pt(IV) pro‐drug
Miller, M. A., Zheng, Y.-R., Gadde, S., Pfirschke, C., Zope, H., Engblom, C., Kohler, R. H., Iwamoto, Y., Yang, K. S., Askevold, B., et al. (2015) · Nature Communications · doi:10.1038/ncomms9692 · Cited by 441
Self-citationEvolution of platinum resistance in high-grade serous ovarian cancer
Cooke, S. L., & Brenton, J. D. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70123-1 · Cited by 213
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Cancer nanomedicine: progress, challenges and opportunities
Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873
Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic
Weiss, C., Carriere, M., Fusco, L., Capua, I., Regla-Nava, J. A., Pasquali, M., Scott, J. A., Vitale, F., Unal, M. A., Mattevi, C., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c03697 · Cited by 601
A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine
Jahangirian, H., Ghasemian lemraski, E., Webster, T. J., Rafiee-Moghaddam, R., & Abdollahi, Y. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s127683 · Cited by 496
Bio-inspired engineering of cell- and virus-like nanoparticles for drug delivery
Parodi, A., Molinaro, R., Sushnitha, M., Evangelopoulos, M., Martinez, J. O., Arrighetti, N., Corbo, C., & Tasciotti, E. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.09.020 · Cited by 266
POxylation as an alternative stealth coating for biomedical applications
Bludau, H., Czapar, A. E., Pitek, A. S., Shukla, S., Jordan, R., & Steinmetz, N. F. (2017) · European Polymer Journal · doi:10.1016/j.eurpolymj.2016.10.041 · Cited by 112
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Metadata
- Authors
- Czapar, A. E., Zheng, Y.-R., Riddell, I. A., Shukla, S., Awuah, S. G., Lippard, S. J., & Steinmetz, N. F.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-03-28
- Volume
- 10
- Issue
- 4
- Pages
- 4119-4126
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2297128620
- Cited by
- 171
- References
- 2
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- green
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