Cited by 112Nanoparticle-Based Drug DeliveryPolymer Surface Interaction StudiesAdvanced Polymer Synthesis and Characterization

POxylation as an alternative stealth coating for biomedical applications

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Bludau, Herdis, Czapar, Anna E., Pitek, Andrzej S., Shukla, Sourabh, Jordan, Rainer, Steinmetz, Nicole F.·2017·European Polymer Journal

Abstract

Polyethylene glycol (PEG) polymers are currently used in a variety of medical formulations to reduce toxicity, minimize immune interactions and improve pharmacokinetics. Despite its widespread use however, the presence of anti-PEG antibodies indicates that this polymer has the potential to be immunogenic and antigenic. Here we present an alternative polymer, poly(2-oxazoline) (POx) for stealth applications, specifically shielding of a proteinaceous nanoparticle from recognition by the immune system. Tobacco mosaic virus (TMV) was used as our testbed due to its potential for use as a nanocarrier for drug delivery and molecular imaging applications.

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Crossref · 10.1016/j.eurpolymj.2016.10.041

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Authors
Bludau, H., Czapar, A. E., Pitek, A. S., Shukla, S., Jordan, R., & Steinmetz, N. F.
Affiliations
  • Technische Universität Dresden (DE)
  • Case Western Reserve University (US)
  • Case Comprehensive Cancer Center (US)
Corresponding author
  • Jordan, Rainer
  • Steinmetz, Nicole F.
Venue
European Polymer Journal
Publisher
Elsevier BV
Published
2017-03
Volume
88
Pages
679-688
ISSN
0014-3057 (ISSN-L)
OpenAlex
W2547204128
Cited by
112
References
47
Citations by year
2026: 13 · 2025: 9 · 2024: 8 · 2023: 15 · 2022: 13 · 2021: 7 · 2020: 16 · 2019: 14 · 2018: 10 · 2017: 6 · 2015: 1
FWCI
4.08
Type
journal article
Language
en
Open access
Locations
  • European Polymer Journal (acceptedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (R03 EB020602, T32 GM007250, TL1 TR000441)
  • Case Western Reserve University
  • Deutscher Akademischer Austauschdienst France
  • National Science Foundation (CHE 1306447)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
Keywords
poly(2-oxazoline), stealth coatings, anti-PEG antibodies, tobacco mosaic virus, drug delivery nanocarriers, molecular imaging

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