POxylation as an alternative stealth coating for biomedical applications
Open accessAbstract
Polyethylene glycol (PEG) polymers are currently used in a variety of medical formulations to reduce toxicity, minimize immune interactions and improve pharmacokinetics. Despite its widespread use however, the presence of anti-PEG antibodies indicates that this polymer has the potential to be immunogenic and antigenic. Here we present an alternative polymer, poly(2-oxazoline) (POx) for stealth applications, specifically shielding of a proteinaceous nanoparticle from recognition by the immune system. Tobacco mosaic virus (TMV) was used as our testbed due to its potential for use as a nanocarrier for drug delivery and molecular imaging applications.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PMeOx may have superior anti-fouling properties to PEG.
“This study, along with others, indicate that PMeOx may actually have superior anti-fouling properties to that of PEG [89].”
From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [89]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Armstrong, J. K., Hempel, G., Koling, S., Chan, L. S., Fisher, T., Meiselman, H. J., & Garratty, G. (2007) · Cancer · doi:10.1002/cncr.22739 · Cited by 699 · see citing works
Engineering targeted viral vectors for gene therapy
Waehler, R., Russell, S. J., & Curiel, D. T. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2141 · Cited by 687 · see citing works
Perry, J. L., Reuter, K. G., Kai, M. P., Herlihy, K. P., Jones, S. W., Luft, J. C., Napier, M. A., Bear, J. E., & DeSimone, J. M. (2012) · Nano Letters · doi:10.1021/nl302638g · Cited by 605 · see citing works
Garay, R. P., El-Gewely, R., Armstrong, J. K., Garratty, G., & Richette, P. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.720969 · Cited by 587 · see citing works
In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer
Lizotte, P. H., Wen, A. M., Sheen, M. R., Fields, J., Rojanasopondist, P., Steinmetz, N. F., & Fiering, S. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.292 · Cited by 484 · see citing works
Self-citationChauhan, V. P., Popović, Z., Chen, O., Cui, J., Fukumura, D., Bawendi, M. G., & Jain, R. K. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201104449 · Cited by 474 · see citing works
Poly (2-oxazoline) s as polymer therapeutics
Luxenhofer, R., Han, Y., Schulz, A., Tong, J., He, Z., Kabanov, A. V., & Jordan, R. (2012) · Macromolecular Rapid Communications · doi:10.1002/marc.201200354 · Cited by 470 · see citing works
Self-citationViral Vectors for Gene Therapy: Translational and Clinical Outlook
Kotterman, M. A., Chalberg, T. W., & Schaffer, D. V. (2015) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-104938 · Cited by 444 · see citing works
Polyoxazoline: Chemistry, Properties, and Applications in Drug Delivery
Viegas, T. X., Bentley, M. D., Harris, J. M., Fang, Z., Yoon, K., Dizman, B., Weimer, R., Mero, A., Pasut, G., & Veronese, F. M. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200049d · Cited by 432 · see citing works
Characterization of Nanoparticles for Therapeutics
Hall, J. B., Dobrovolskaia, M. A., Patri, A. K., & McNeil, S. E. (2007) · Nanomedicine · doi:10.2217/17435889.2.6.789 · Cited by 413 · see citing works
Kenworthy, A. K., Hristova, K. A., Needham, D., & McIntosh, T. J. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80369-3 · Cited by 404 · see citing works
Woodle, M. C., Engbers, C. M., & Zalipsky, S. (1994) · Bioconjugate Chemistry · doi:10.1021/bc00030a001 · Cited by 361 · see citing works
Poly-2-methyl-2-oxazoline: A Peptide-like Polymer for Protein-Repellent Surfaces
Konradi, R., Pidhatika, B., Mühlebach, A., & Textor, M. (2008) · Langmuir · doi:10.1021/la702917z · Cited by 356 · see citing works
Surface Initiated Living Cationic Polymerization of 2-Oxazolines
Jordan, R., & Ulman, A. (1998) · Journal of the American Chemical Society · doi:10.1021/ja973392r · Cited by 344 · see citing works
Self-citationEvaluation of Blood Clearance Rates and Biodistribution of Poly(2-oxazoline)-Grafted Liposomes§
Zalipsky, S., Hansen, C. B., Oaks, J. M., & Allen, T. M. (1996) · Journal of Pharmaceutical Sciences · doi:10.1021/js9504043 · Cited by 317 · see citing works
Virus-mediated gene delivery for human gene therapy
Giacca, M., & Zacchigna, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.008 · Cited by 302 · see citing works
Wiesbrock, F., Hoogenboom, R., Leenen, M. A. M., Meier, M. A. R., & Schubert, U. S. (2005) · Macromolecules · doi:10.1021/ma0474170 · Cited by 288 · see citing works
Doubly amphiphilic poly(2-oxazoline)s as high-capacity delivery systems for hydrophobic drugs
Luxenhofer, R., Schulz, A., Roques, C., Li, S., Bronich, T. K., Batrakova, E. V., Jordan, R., & Kabanov, A. V. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.057 · Cited by 287 · see citing works
Self-citationGanson, N. J., Povsic, T. J., Sullenger, B. A., Alexander, J. H., Zelenkofske, S. L., Sailstad, J. M., Rusconi, C. P., & Hershfield, M. S. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.034 · Cited by 275 · see citing works
Comparative stability studies of poly(2-methyl-2-oxazoline) and poly(ethylene glycol) brush coatings
Pidhatika, B., Rodenstein, M., Chen, Y., Rakhmatullina, E., Mühlebach, A., Acikgöz, C., Textor, M., & Konradi, R. (2012) · Biointerphases · doi:10.1007/s13758-011-0001-y · Cited by 251 · see citing works
Richter, A. W., & Akerblom, E. B. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000233512 · Cited by 229 · see citing works
Croyle, M. A., Chirmule, N. B., Zhang, Y., & Wilson, J. M. (2001) · Journal of Virology · doi:10.1128/jvi.75.10.4792-4801.2001 · Cited by 229 · see citing works
Wiesbrock, F., Hoogenboom, R., Abeln, C. H., & Schubert, U. S. (2004) · Macromolecular Rapid Communications · doi:10.1002/marc.200400369 · Cited by 193 · see citing works
Bruckman, M. A., Randolph, L. N., VanMeter, A., Hern, S., Shoffstall, A. J., Taurog, R. E., & Steinmetz, N. F. (2013) · Virology · doi:10.1016/j.virol.2013.10.035 · Cited by 181 · see citing works
Self-citationThe Impact of Aspect Ratio on the Biodistribution and Tumor Homing of Rigid Soft‐Matter Nanorods
Shukla, S., Eber, F. J., Nagarajan, A. S., DiFranco, N. A., Schmidt, N., Wen, A. M., Eiben, S., Twyman, R. M., Wege, C., & Steinmetz, N. F. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201400641 · Cited by 177 · see citing works
Self-citationTailored poly(2-oxazoline) polymer brushes to control protein adsorption and cell adhesion
Zhang, N., Pompe, T., Amin, I., Luxenhofer, R., Werner, C., & Jordan, R. (2012) · Macromolecular Bioscience · doi:10.1002/mabi.201200026 · Cited by 171 · see citing works
Self-citationTobacco Mosaic Virus Delivery of Phenanthriplatin for Cancer therapy
Czapar, A. E., Zheng, Y., Riddell, I. A., Shukla, S., Awuah, S. G., Lippard, S. J., & Steinmetz, N. F. (2016) · ACS Nano · doi:10.1021/acsnano.5b07360 · Cited by 171 · see citing works
Self-citationPEG conjugation moderately protects adeno‐associated viral vectors against antibody neutralization
Lee, G. K., Maheshri, N., Kaspar, B., & Schaffer, D. V. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20562 · Cited by 169 · see citing works
Bruckman, M. A., Jiang, K., Simpson, E. J., Randolph, L. N., Luyt, L. G., Yu, X., & Steinmetz, N. F. (2014) · Nano Letters · doi:10.1021/nl404816m · Cited by 165 · see citing works
Self-citationShukla, S., Ablack, A. L., Wen, A. M., Lee, K. L., Lewis, J. D., & Steinmetz, N. F. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300240m · Cited by 154 · see citing works
Self-citationShukla, R. K., Kumar, A., Vallabani, N. V. S., et al. (2013) · Nanomedicine · doi:10.2217/nnm.13.100 · Cited by 143 · see citing works
"Characterization of Nanoparticles Intended for Drug Delivery"
Gabor, F. (2011) · Scientia Pharmaceutica · doi:10.3797/scipharm.br-11-01 · Cited by 142 · see citing works
Long-term safety of pegloticase in chronic gout refractory to conventional treatment
Becker, M. A., Baraf, H. S. B., Yood, R. A., Dillon, A., Vázquez‐Mellado, J., Ottery, F. D., Khanna, D., & Sundy, J. S. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-201795 · Cited by 107 · see citing works
Humans Have Antibodies against a Plant Virus: Evidence from Tobacco Mosaic Virus
Liu, R., Vaishnav, R., Roberts, A. M., & Friedland, R. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060621 · Cited by 95 · see citing works
Interior Engineering of a Viral Nanoparticle and Its Tumor Homing Properties
Wen, A. M., Shukla, S., Saxena, P., Aljabali, A. A. A., Yıldız, İ., Dey, S. K., Mealy, J. E., Yang, A. C., Evans, D. J., Lomonossoff, G. P., et al. (2012) · Biomacromolecules · doi:10.1021/bm301278f · Cited by 95 · see citing works
Self-citationPitek, A. S., Wen, A. M., Shukla, S., & Steinmetz, N. F. (2016) · Small · doi:10.1002/smll.201502458 · Cited by 91 · see citing works
Self-citationLee, K. L., Shukla, S., Wu, M., Ayat, N. R., Sanadi, C. E. E., Wen, A. M., Edelbrock, J. F., Pokorski, J. K., Commandeur, U., Dubyak, G., et al. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.03.001 · Cited by 89 · see citing works
Self-citationStabilization of Virus‐like Particles with Poly(2‐oxazoline)s
Manzenrieder, F., Luxenhofer, R., Retzlaff, M., Jordan, R., & Finn, M. G. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201006134 · Cited by 86 · see citing works
Self-citationOncolytic Viruses as Anticancer Vaccines
Woller, N., rlevik, E. G. ⁄., Ureche, C.-I., Schumacher, A., & hnel, F. K. ⁄. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00188 · Cited by 85 · see citing works
Tong, J., Yi, X., Luxenhofer, R., Banks, W. A., Jordan, R., Zimmerman, M. C., & Kabanov, A. V. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300496x · Cited by 77 · see citing works
Self-citationBiodistribution and Clearance of A Filamentous Plant Virus in Healthy and Tumor-Bearing Mice
Shukla, S., Wen, A. M., Ayat, N. R., Commandeur, U., Gopalkrishnan, R., Broome, A., Lozada, K. W., Keri, R. A., & Steinmetz, N. F. (2013) · Nanomedicine · doi:10.2217/nnm.13.75 · Cited by 72 · see citing works
Self-citationClick‐Chemistry: An Alternative Way to Functionalize Poly(2‐methyl‐2‐oxazoline)
Volet, G., Lav, T., Babinot, J., & Amiel, C. (2010) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201000556 · Cited by 61 · see citing works
Wen, A. M., Lee, K. L., Cao, P., Pangilinan, K. D., Carpenter, B. L., Lam, P. M. W., Veliz, F. A., Ghiladi, R. A., Advíncula, R. C., & Steinmetz, N. F. (2016) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00075 · Cited by 57 · see citing works
Self-citationForeman, M. B., Coffman, J. P., Murcia, M. J., Cesana, S., Jordan, R., Smith, G. S., & Naumann, C. A. (2002) · Langmuir · doi:10.1021/la0261390 · Cited by 56 · see citing works
Self-citationA Low Protein Binding Cationic Poly(2‐oxazoline) as Non‐Viral Vector
He, Z., Miao, L., Jordan, R., Manickam, D. S., Luxenhofer, R., & Kabanov, A. V. (2015) · Macromolecular Bioscience · doi:10.1002/mabi.201500021 · Cited by 46 · see citing works
Self-citationWen, A. M., Le, N., Zhou, X., Steinmetz, N. F., & Popkin, D. L. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00344 · Cited by 22 · see citing works
Self-citationShukla, S., Dorand, R. D., Myers, J., Woods, S. E., Gulati, N. M., Stewart, P. L., Commandeur, U., Huang, A. Y.-C., & Steinmetz, N. F. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00060 · Cited by 21 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Hwang, D., Ramsey, J. D., & Kabanov, A. V. (2020) · Advanced drug delivery reviews · doi:10.1016/j.addr.2020.09.009 · Cited by 699 · see citing works
“This study, alongwith others, indicate that PMeOx may actually have superior anti-fouling properties to that of PEG [89].”
ResultStealth Coating of Nanoparticles in Drug-Delivery Systems
Fam, S. Y., Chee, C. F., Yong, C. Y., Ho, K. L., Mariatulqabtiah, A. R., & Tan, W. S. (2020) · Nanomaterials · doi:10.3390/nano10040787 · Cited by 430 · see citing works
Poly(2-oxazoline)s based biomaterials: a comprehensive and critical update
Lorson, T., Lübtow, M. M., Wegener, E., Haider, M. S., Borova, S., Nahm, D., Jordan, R., Sokolski-Papkov, M., Kabanov, A. V., & Luxenhofer, R. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.022 · Cited by 391 · see citing works
Self-citationCell membrane coated nanocarriers - an efficient biomimetic platform for targeted therapy
Dash, P., Piras, A. M., & Dash, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.012 · Cited by 266 · see citing works
The in vivo fate of polymeric micelles
Cai, Y., Qi, J., Lu, Y., He, H., & Wu, W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114463 · Cited by 154 · see citing works
Tavano, R., Gabrielli, L., Lubian, E., Fedeli, C., Visentin, S., de Laureto, P. P., Arrigoni, G., Geffner-Smith, A., Chen, F., Simberg, D., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b01806 · Cited by 142 · see citing works
Drug Delivery Systems Based on Poly(2‐Oxazoline)s and Poly(2‐Oxazine)s
Sedláček, O., & Hoogenboom, R. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201900168 · Cited by 130 · see citing works
Poly(ethylene glycol) alternatives in biomedical applications
Yao, X., Qi, C., Sun, C., Huo, F., & Jiang, X. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101738 · Cited by 129 · see citing works
Hydrophilicity Regulates the Stealth Properties of Polyphosphoester‐Coated Nanocarriers
Simon, J., Wolf, T., Klein, K., Landfester, K., Wurm, F. R., & Mailänder, V. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201800272 · Cited by 122 · see citing works
Mills, J. A., Liu, F., Jarrett, T. R., Fletcher, N. L., & Thurecht, K. J. (2022) · Biomaterials Science · doi:10.1039/d2bm00181k · Cited by 124 · see citing works
Bioinspired Shielding Strategies for Nanoparticle Drug Delivery Applications
Gulati, N. M., Stewart, P. L., & Steinmetz, N. F. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00292 · Cited by 119 · see citing works
Self-citationPlant viruses and bacteriophages for drug delivery in medicine and biotechnology
Czapar, A. E., & Steinmetz, N. F. (2017) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2017.03.013 · Cited by 117 · see citing works
Self-citationJana, S., & Uchman, M. (2020) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2020.101252 · Cited by 110 · see citing works
Antibodies against polyethylene glycol in human blood: A literature review
Lu, H., Wang, Z., Wei, X., Shi, J., & Li, C. (2020) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2020.106678 · Cited by 101 · see citing works
Plant virus-based materials for biomedical applications: Trends and prospects
Eiben, S., Koch, C., Altintoprak, K., Southan, A., Tovar, G. E. M., Laschat, S., Weiss, I. M., & Wege, C. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.08.011 · Cited by 96 · see citing works
Poly(2‐oxazoline) Hydrogels: State‐of‐the‐Art and Emerging Applications
Dargaville, T. R., Park, J., & Hoogenboom, R. (2018) · Macromolecular Bioscience · doi:10.1002/mabi.201800070 · Cited by 90 · see citing works
Franke, C. E., Czapar, A. E., Patel, R. B., & Steinmetz, N. F. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00466 · Cited by 76 · see citing works
Self-citationPEGylation technology: addressing concerns, moving forward
Simberg, D., Barenholz, Y., Roffler, S. R., Landfester, K., Kabanov, A. V., & Moghimi, S. M. (2025) · Drug Delivery · doi:10.1080/10717544.2025.2494775 · Cited by 60 · see citing works
Abilova, G. K., Kaldybekov, D. B., Ozhmukhametova, E. K., Saimova, A., Kazybayeva, D. S., Serikbayevna, I. G., & Khutoryanskiy, V. V. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2019.04.016 · Cited by 58 · see citing works
Delaittre, G. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2019.109281 · Cited by 63 · see citing works
Poly(2-oxazoline)-protein conjugates
Sedláček, O., de la Rosa, V. R., & Hoogenboom, R. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2019.109246 · Cited by 54 · see citing works
Gaballa, S. A., Shimizu, T., Ando, H., Takata, H., Emam, S. E., Ramadan, E., Naguib, Y. W., Mady, F. M., Khaled, K. A., & Ishida, T. (2023) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2023.11.001 · Cited by 58 · see citing works
Youden, B., Jiang, R., Carrier, A. J., Servos, M. R., & Zhang, X. (2022) · ACS Nano · doi:10.1021/acsnano.2c06337 · Cited by 51 · see citing works
Biomimetic and Bioinspired Nanoparticles for Targeted Drug Delivery
Gagliardi, M. (2017) · Therapeutic Delivery · doi:10.4155/tde-2017-0013 · Cited by 51 · see citing works
Shin, K., Suh, H., Grundler, J., Lynn, A. Y., Pothupitiya, J. U., Moscato, Z. M., Reschke, M., Bracaglia, L. G., Piotrowski-Daspit, A. S., & Saltzman, W. M. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121676 · Cited by 49 · see citing works
Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics
Sokullu, E., Abyaneh, H. S., & Gauthier, M. A. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11050211 · Cited by 48 · see citing works
Lübtow, M. M., Mrlík, M., Hahn, L., Altmann, A., Beudert, M., Lühmann, T. C., & Luxenhofer, R. (2019) · Journal of Functional Biomaterials · doi:10.3390/jfb10030036 · Cited by 45 · see citing works
Elongated Plant Virus-Based Nanoparticles for Enhanced Delivery of Thrombolytic Therapies
Pitek, A. S., Wang, Y., Gulati, S., Gao, H., Stewart, P. L., Simon, D. I., & Steinmetz, N. F. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00559 · Cited by 45 · see citing works
Self-citationTargeted nanomedicines for the treatment of bone disease and regeneration
Ordikhani, F., Zandi, N., Mazaheri, M., Luther, G. A., Ghovvati, M., Akbarzadeh, A., & Annabi, N. (2020) · Medicinal Research Reviews · doi:10.1002/med.21759 · Cited by 44 · see citing works
Wang, R., Zhang, Z., Liu, B., Xue, J., Liu, F., Tang, T., Liu, W., Feng, F., & Qu, W. (2021) · Biomaterials Science · doi:10.1039/d0bm02221g · Cited by 42 · see citing works
Plant viral and bacteriophage delivery of nucleic acid therapeutics
Lam, P. M. W., & Steinmetz, N. F. (2017) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1487 · Cited by 42 · see citing works
Self-citationPorello, I., Bono, N., Candiani, G., & Cellesi, F. (2024) · Polymer Chemistry · doi:10.1039/d4py00234b · Cited by 38 · see citing works
Synthesis of defined high molar mass poly(2-methyl-2-oxazoline)
Sedláček, O., Monnery, B. D., & Hoogenboom, R. (2019) · Polymer Chemistry · doi:10.1039/c9py00013e · Cited by 37 · see citing works
Kong, Y. W., & Dreaden, E. C. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.879988 · Cited by 37 · see citing works
Liposomal Nanostructures for Drug Delivery in Gastrointestinal Cancers
Das, M., & Huang, L. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.254797 · Cited by 36 · see citing works
Wloka, T., Czich, S., Kleinsteuber, M., Moek, E., Weber, C., Gottschaldt, M., Liefeith, K., & Schubert, U. S. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2019.109295 · Cited by 36 · see citing works
Nanomedicine for advanced cancer immunotherapy
Diep, Y. N., Kim, T. J., Cho, H., & Lee, L. P. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.10.004 · Cited by 34 · see citing works
Смагина, В. В., Александрович, Ю. П., Николаевич, К. А., & Chistyakov, E. M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030830 · Cited by 35 · see citing works
Humphries, J., Pizzi, D., Sonderegger, S., Fletcher, N. L., Houston, Z. H., Bell, C. A., Kempe, K., & Thurecht, K. J. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00765 · Cited by 33 · see citing works
Placci, M., Giannotti, M. I., & Muro, S. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114683 · Cited by 33 · see citing works
Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery
Zewail, M. B., Yang, G., Fan, Y., Hui, Y., Zhao, C., & Liu, Y. (2025) · Aggregate · doi:10.1002/agt2.70054 · Cited by 34 · see citing works
Polyphosphoester surfactants as general stealth coatings for polymeric nanocarriers
Bauer, K. N., Simon, J., Mailänder, V., Landfester, K., & Wurm, F. R. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.09.016 · Cited by 32 · see citing works
Porous Poly(2-oxazoline)-Based Polymers for Removal and Quantification of Phenolic Compounds
Cegłowski, M., Schroeder, G., & Hoogenboom, R. (2020) · Chemistry of Materials · doi:10.1021/acs.chemmater.0c01559 · Cited by 31 · see citing works
Zwitterionic Polymer-Decorated Lipid Nanoparticles for mRNA Delivery in Mammalian Cells
Khunsuk, P.-O., Pongma, C., Palaga, T., & Hoven, V. P. (2023) · Biomacromolecules · doi:10.1021/acs.biomac.3c00649 · Cited by 29 · see citing works
Moustafine, R. I., Viktorova, A. S., & Khutoryanskiy, V. V. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.01.002 · Cited by 30 · see citing works
Organocyclophosphazenes and Materials Based on Them for Pharmaceuticals and Biomedicine
Александрович, Ю. П., Tupikov, A. S., & Chistyakov, E. M. (2025) · Biomolecules · doi:10.3390/biom15020262 · Cited by 29 · see citing works
Noncovalent PEGylation of protein and peptide therapeutics
Andrianov, A. K. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1897 · Cited by 29 · see citing works
Czich, S., Wloka, T., Rothe, H., Rost, J., Penzold, F., Kleinsteuber, M., Gottschaldt, M., Schubert, U. S., & Liefeith, K. (2020) · Molecules · doi:10.3390/molecules25215066 · Cited by 28 · see citing works
Poly(2‐ethyl‐2‐oxazoline) grafted gellan gum for potential application in transmucosal drug delivery
Lavikainen, J., Dauletbekova, M., Toleutay, G., Kaliva, M., Chatzinikolaidou, Μ., Kudaibergenov, S. E., Теньковцев, А. В., Khutoryanskiy, V. V., Vamvakaki, M., & Aseyev, V. O. (2021) · Polymers for Advanced Technologies · doi:10.1002/pat.5298 · Cited by 28 · see citing works
50 years of poly(2-oxazoline)s
Hoogenboom, R. (2017) · European Polymer Journal · doi:10.1016/j.eurpolymj.2017.01.014 · Cited by 27 · see citing works
Kerscher, B., Trötschler, T. M., Pásztói, B., Groeer, S., Szabó, Á., Iván, B., & Mülhaupt, R. (2019) · Macromolecules · doi:10.1021/acs.macromol.9b00296 · Cited by 27 · see citing works
Cegłowski, M., & Hoogenboom, R. (2018) · Macromolecules · doi:10.1021/acs.macromol.8b01068 · Cited by 27 · see citing works
Landry, M. R., DuRoss, A. N., Neufeld, M. J., Hahn, L., Sahay, G., Luxenhofer, R., & Sun, C. (2020) · Materials Today Bio · doi:10.1016/j.mtbio.2020.100082 · Cited by 25 · see citing works
Matos, A. I., Peres, C., Carreira, B., Moura, L. I. F., Acúrcio, R. C., Vogel, T., Wegener, E., Ribeiro, F., Afonso, M. B., Santos, F. M. F., et al. (2023) · Advanced Science · doi:10.1002/advs.202300299 · Cited by 25 · see citing works
Self-citationPoly(2-oxazoline)s: synthesis and biomedical applications
Yang, L., Wang, F., Ren, P., Zhang, T., & Zhang, Q. (2023) · Macromolecular Research · doi:10.1007/s13233-023-00116-x · Cited by 25 · see citing works
Šrámková, P., Zahoranová, A., Kelar, J., Tučeková, Z. K., Stupavská, M., Krumpolec, R., Jurmanová, J., Kováčik, D., & Černák, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-66423-w · Cited by 24 · see citing works
A Concise Review on Effect of PEGylation on the Properties of Lipid-Based Nanoparticles
Krishnan, J., Poomalai, P., Ravichandran, A., Reddy, A., & Sureshkumar, R. (2024) · Assay and Drug Development Technologies · doi:10.1089/adt.2024.015 · Cited by 23 · see citing works
Leer, K., Reichel, L. S., Kimmig, J., Richter, F., Hoeppener, S., Brendel, J. C., Zechel, S., Schubert, U. S., & Traeger, A. (2023) · Small · doi:10.1002/smll.202306116 · Cited by 22 · see citing works
Wen, A. M., Le, N., Zhou, X., Steinmetz, N. F., & Popkin, D. L. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00344 · Cited by 22 · see citing works
Self-citationInulin-g-poly-D,L-lactide, a sustainable amphiphilic copolymer for nano-therapeutics
Sardo, C., Mencherini, T., Tommasino, C., Esposito, T., Russo, P., Gaudio, P. D., & Aquino, R. P. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01135-4 · Cited by 19 · see citing works
Shafaei, N., Khorshidi, S., & Karkhaneh, A. (2023) · Journal of Biomaterials Applications · doi:10.1177/08853282231185352 · Cited by 19 · see citing works
Thermoresponsive Polyoxazolines as Vectors for Transfection of Nucleic Acids
Haladjova, E., Rangelov, S., & Tsvetanov, C. B. (2020) · Polymers · doi:10.3390/polym12112609 · Cited by 19 · see citing works
Tavano, R., Morillas-Becerril, L., Geffner-Smith, A., Ronzani, G., Gervasutti, R., Arrigoni, G., Battisti, I., Morbidelli, M., de Laureto, P. P., Palazzi, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57648-2 · Cited by 18 · see citing works
Modulation of Platelet-Surface Activation: Current State and Future Perspectives
Apte, G., Börke, J. M., Rothe, H., Liefeith, K., & Nguyen, T. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00822 · Cited by 18 · see citing works
Lobaz, V., Konefał, R., Pánek, J., Vlk, M., Kozempel, J., Petřík, M., Nový, Z., Gurská, S., Znojek, P., Štěpánek, P., et al. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.03.057 · Cited by 17 · see citing works
Equilibrium Swelling of Biocompatible Thermo-Responsive Copolymer Gels
Drozdov, A. D. (2021) · Gels · doi:10.3390/gels7020040 · Cited by 16 · see citing works
Vasileva, L. A., Gaynanova, G. A., Romanova, E. A., Petrov, K. A., Feng, C., Zakharova, L. Y., & Sinyashin, O. G. (2024) · Russian Chemical Reviews · doi:10.59761/rcr5150 · Cited by 15 · see citing works
Gubarev, A. S., Lezov, A. A., Podseval’nikova, A. N., Mikusheva, N. G., Fetin, P. A., Zorin, I. M., Aseyev, V. O., Sedláček, O., Hoogenboom, R., & Tsvetkov, V. N. (2023) · Polymers · doi:10.3390/polym15030623 · Cited by 15 · see citing works
Nurlanovna, M. D., Filippov, S. K., Yestemes, S., Serikbayevna, I. G., & Khutoryanskiy, V. V. (2022) · European Polymer Journal · doi:10.1016/j.eurpolymj.2022.111005 · Cited by 15 · see citing works
Pashirova, T. N., Afonso, A. B., Terekhova, N. V., Kamalov, M. I., Masson, P., & Souto, E. B. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90471-1.00005-0 · Cited by 13 · see citing works
Various lipid anchors on amphiphilic polyoxazolines to reach efficient intracellular delivery
Simon, L., Taddeo, M. D., Coeurvolan, A., Colpaert, M., Richard, J., Devoisselle, J., Morille, M., Marcotte, N., Bégu, S., & Lapinte, V. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123103 · Cited by 12 · see citing works
Recent advances in smart gold nanoparticles for photothermal therapy
Moreira, A. F., Filipe, H. A. L., Miguel, S. P., Ribeiro, M. P., & Coutinho, P. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2500912 · Cited by 12 · see citing works
Simon, J., Wolf, T., Klein, K., Landfester, K., Wurm, F. R., & Mailänder, V. (2018) · Angewandte Chemie · doi:10.1002/ange.201800272 · Cited by 12 · see citing works
Schoolaert, E., Merckx, R., Becelaere, J., Rijssegem, S., Hoogenboom, R., & Clerck, K. D. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202106859 · Cited by 10 · see citing works
Poly(2-oxazoline)-based drug delivery systems for cancer therapy
Kulkarni, B., & Becer, C. R. (2025) · European Polymer Journal · doi:10.1016/j.eurpolymj.2025.114292 · Cited by 10 · see citing works
Biocatalytically induced surface modification of the tobacco mosaic virus and the bacteriophage M13
Vignali, V., de Miranda, B. S., Lodoso‐Torrecilla, I., van Nisselroy, C., Hoogenberg, B.-J., Dantuma, S., Hollmann, F., de Vries, J. W., Warszawik, E. M., Fischer, R., et al. (2018) · Chemical Communications · doi:10.1039/c8cc08042a · Cited by 9 · see citing works
Zhang, H., Liu, X., Xu, K., Du, B., Zhu, C., & Li, Y. (2020) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.110054 · Cited by 9 · see citing works
Mobley, E. B., Lin, E. Y., & Sletten, E. M. (2024) · ACS Central Science · doi:10.1021/acscentsci.4c01570 · Cited by 8 · see citing works
Humphries, J., Warne, N. M., Feeney, O. M., Thurecht, K. J., & Kempe, K. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114838 · Cited by 8 · see citing works
Poly(2-Ethyl-2-Oxazoline)–IR780 Conjugate Nanoparticles for Breast Cancer Phototherapy
Alves, C. G., Lima‐Sousa, R., Melo, B. L., Ferreira, P. C. N., Moreira, A. F., Correia, I. J., & de Melo‐Diogo, D. (2022) · Nanomedicine · doi:10.2217/nnm-2022-0218 · Cited by 8 · see citing works
Elter, J. K., Sedlák, F., Palušák, T., Bernardová, N., Lobaz, V., Tihlaříková, E., Neděla, V., Šácha, P., & Hrubý, M. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.4c01052 · Cited by 7 · see citing works
Kim, D., Duoto, B. A., Varanasi, M., Goldenfeld, G., & Steinmetz, N. F. (2026) · Chemical Science · doi:10.1039/d5sc02211h · Cited by 7 · see citing works
Self-citationShielding of Hepatitis B Virus-Like Nanoparticle with Poly(2-Ethyl-2-Oxazoline)
Fam, S. Y., Chee, C. F., Yong, C. Y., Ho, K. L., Mariatulqabtiah, A. R., Lau, H. Y., & Tan, W. S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194903 · Cited by 7 · see citing works
Leer, K., Reichel, L. S., Wilhelmi, M., Brendel, J. C., & Traeger, A. (2024) · ACS Macro Letters · doi:10.1021/acsmacrolett.3c00633 · Cited by 5 · see citing works
Biomedical Applications of Viral Nanoparticles in Vaccine Therapy
Venkataraman, S., Reddy, V. S., & Khurana, S. M. P. (2020) · Springer eBooks · doi:10.1007/978-981-32-9898-9_9 · Cited by 5 · see citing works
Lee, S. Y., Lee, S. H., Tor, Y. S., Yong, P. V. C., & Ho, K. L. (2026) · BioNanoScience · doi:10.1007/s12668-025-02384-6 · Cited by 4 · see citing works
Wakabayashi, R., Ishii, K., Yamada, T., & Komatsu, T. (2024) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202400183 · Cited by 4 · see citing works
Biomimetic Nanosystems in Targeted Drug Delivery
Dash, P., & Dash, M. (2022) · Springer eBooks · doi:10.1007/978-981-16-4566-2_3 · Cited by 4 · see citing works
Lobaz, V., Liščáková, V., Sedlák, F., Musil, D., Petrova, S. L., Šeděnková, I., Pánek, J., Kučka, J., Konefał, R., Tihlaříková, E., et al. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113564 · Cited by 4 · see citing works
Functional Polyglycidol-Based Block Copolymers for DNA Complexation
Kalinova, R. G., Valchanova, M., Dimitrov, I. V., Turmanova, S., Ugrinova, I., Petrova, M., Vlahova, Z., & Rangelov, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179606 · Cited by 3 · see citing works
Knowledge-Based Design of Multifunctional Polymeric Nanoparticles
Behnke, M., Holick, C. T., Vollrath, A., Schubert, S., & Schubert, U. S. (2023) · Handbook of experimental pharmacology · doi:10.1007/164_2023_649 · Cited by 3 · see citing works
Saka, O. M., Bolat, Z. B., Telci, D., Şahi̇n, F., Gülyüz, S., Özköse, U. U., Yılmaz, Ö., & Bozkır, A. (2023) · Polymers for Advanced Technologies · doi:10.1002/pat.6235 · Cited by 3 · see citing works
Site-specific targeting in immunoliposomal nanomedicine for oncology: opportunities and limitations
Milczarek, M., & Kleczkowska, P. (2026) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2026.115004 · Cited by 2 · see citing works
Kampmann, A., Hiller, W., & Weberskirch, R. (2022) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202200211 · Cited by 2 · see citing works
Ortaç, B., Mutlu, S., Yılmaz, A. H., & Yılmaz, S. S. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1006095 · Cited by 2 · see citing works
Poly(2-oxazoline)–protein conjugates
Sedláček, O., de la Rosa, V. R., & Hoogenboom, R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64081-9.00018-8 · Cited by 2 · see citing works
Bio-inspired nanoparticles as drug delivery vectors
Gagliardi, M., & Cecchini, M. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820757-4.00002-8 · Cited by 1 · see citing works
Medical Applications of Plant Virus Nanoparticles
Rutkowska, D. A. (2024) · Concepts and strategies in plant sciences · doi:10.1007/978-981-97-0176-6_15 · Cited by 1 · see citing works
Antibody-mediated recognition of chiral poly(2-oxazoline) nanorods driven by enantioselectivity
Pizzi, D., Humphries, J., Liu, F., Finnegan, J. R., Li, J., Fletcher, N. L., Bell, C. A., Thurecht, K. J., & Kempe, K. (2026) · Chemical Science · doi:10.1039/d6sc05017d · Cited by 1 · see citing works
Waterborne Polyurethanes for Corrosion Protection
de Souza, F. M., & Gupta, R. K. (2021) · Advances in Science, Technology & Innovation/Advances in science, technology & innovation · doi:10.1007/978-3-030-72869-4_1 · Cited by 1 · see citing works
- Authors
- Bludau, H., Czapar, A. E., Pitek, A. S., Shukla, S., Jordan, R., & Steinmetz, N. F.
- Affiliations
- Technische Universität Dresden (DE)
- Case Western Reserve University (US)
- Case Comprehensive Cancer Center (US)
- Corresponding author
- Jordan, Rainer
- Steinmetz, Nicole F.
- Venue
- European Polymer Journal
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 88
- Pages
- 679-688
- ISSN
- 0014-3057 (ISSN-L)
- PMC
- PMC5510027
- OpenAlex
- W2547204128
- Cited by
- 112
- References
- 47
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 8 · 2023: 15 · 2022: 13 · 2021: 7 · 2020: 16 · 2019: 14 · 2018: 10 · 2017: 6 · 2015: 1
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- European Polymer Journal (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R03 EB020602, T32 GM007250, TL1 TR000441)
- Case Western Reserve University
- Deutscher Akademischer Austauschdienst France
- National Science Foundation (CHE 1306447)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- poly(2-oxazoline), stealth coatings, anti-PEG antibodies, tobacco mosaic virus, drug delivery nanocarriers, molecular imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review