The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
A Hydrogel-Based Hybrid Theranostic Contact Lens for Fungal Keratitis
Abstract
Fungal keratitis, a severe ocular disease, is one of the leading causes of ocular morbidity and blindness, yet it is often neglected, especially in developing countries. Therapeutic efficacy of traditional treatment such as eye drops is very limited due to poor bioavailability, whereas intraocular injection might cause serious side effects. Herein, we designed and fabricated a hybrid hydrogel-based contact lens which comprises quaternized chitosan (HTCC), silver nanoparticles, and graphene oxide (GO) with a combination of antibacterial and antifungal functions. The hydrogel is cross-linked through electrostatic interactions between GO and HTCC, resulting in strong mechanical properties. Voriconazole (Vor), an antifungal drug, can be loaded onto GO which retains the drug and promotes its sustained release from the hydrogel-based contact lenses. The contact lenses also exhibited good antimicrobial functions in view of glycidyltrimethylammonium chloride and silver nanoparticles. The results from in vitro and in vivo experiments demonstrate that contact lenses loaded with Vor have excellent efficacy in antifungal activity in vitro and could significantly enhance the therapeutic effects on a fungus-infected mouse model. The results indicate that this hydrogel contact lenses-based drug delivery system might be a promising therapeutic approach for a rapid and effective treatment of fungal keratitis.
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Cited by
Han, H., Li, S., Xu, M., Zhong, Y., Fan, W., Xu, J., Zhou, T., Ji, J., Ye, J., & Yao, K. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114770 · Cited by 322
From design to applications of stimuli-responsive hydrogel strain sensors
Zhang, D., Ren, B., Zhang, Y., Xu, L., Huang, Q., He, Y., Li, X., Wu, J., Yang, J., Chen, Q., et al. (2020) · Journal of Materials Chemistry B · doi:10.1039/c9tb02692d · Cited by 199
Progress and prospects in chitosan derivatives: Modification strategies and medical applications
Ding, S., Wang, Y., Li, J., & Chen, S. (2021) · Journal of Materials Science & Technology · doi:10.1016/j.jmst.2020.12.008 · Cited by 92
An insight on ophthalmic drug delivery systems: focus on polymeric biomaterials-based carriers
Shafiq, M., Rafique, M., Cui, Y., Pan, L., Do, C.-W., & Ho, E. A. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.08.041 · Cited by 67
Han, Y., Xu, C., Shi, H., Yu, F., Zhong, Y., Liu, Z., Loh, X. J., Wu, Y.-L., Li, Z., & Li, C. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.129734 · Cited by 30
Metadata
- Authors
- Huang, J.-F., Zhong, J., Chen, G.-P., Lin, Z.-T., Deng, Y., Liu, Y.-L., Cao, P.-Y., Wang, B., Wei, Y., Wu, T., Yuan, J., & Jiang, G.-B.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-06-03
- Volume
- 10
- Issue
- 7
- Pages
- 6464-6473
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2419310936
- Cited by
- 257
- References
- 47
- FWCI
- 16.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huang, J.-F., Zhong, J., Chen, G.-P., Lin, Z.-T., Deng, Y., Liu, Y.-L., Cao, P.-Y., Wang, B., Wei, Y., Wu, T., Yuan, J., & Jiang, G.-B. (2016). A Hydrogel-Based Hybrid Theranostic Contact Lens for Fungal Keratitis. ACS Nano. https://doi.org/10.1021/acsnano.6b00601
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