Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis
Abstract
To evaluate the efficacy and safety of voriconazole in acute invasive aspergillosis (IA), an open, noncomparative multicenter study was conducted. Immunocompromised patients with IA were treated with intravenously administered voriconazole 6 mg/kg twice a day (b.i.d.) twice and then 3 mg/kg b.i.d. for 6-27 days, followed by 200 mg b.i.d. administered orally for up to 24 weeks. Response was assessed by clinical and radiographic change. A total of 116 patients were assessable. IA was proven in 48 (41%) and probable in 68 patients. Voriconazole was given as primary therapy in 60 (52%). Good responses were seen in 56 (48%); 16 (14%) showed complete response and 40 (34%) partial response. A stable response was seen in 24 patients (21%), and 36 (31%) of the infections failed to respond to therapy. Good responses were seen in 60% of those with pulmonary or tracheobronchial IA (n=84), 16% with cerebral IA (n=19), 58% with hematologic disorders (n=67), and 26% of allogeneic stem cell transplant recipients (n=23). Voriconazole is efficacious in treating acute IA.
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Treatment success in retrospective analyses has been associated with voriconazole serum trough concentrations of 1 to 2 mg/mL.
“Treatment success in these retrospective analyses has been associated with serum trough concentrations of 1 to 2 mg/mL.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [153]
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- Authors
- Denning, D. W., Ribaud, P., Milpied, N., Caillot, D., Herbrecht, R., Thiel, E., Haas, A., Ruhnke, M., & Lode, H.
- Affiliations
- North Manchester General Hospital (GB)
- Hôpital Saint-Louis (FR)
- CHU Dijon Bourgogne (FR)
- Hôpital d'Hautepierre (FR)
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Denning, D. W.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-03-01
- Volume
- 34
- Issue
- 5
- Pages
- 563-571
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W1964720826
- Cited by
- 844
- References
- 45
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 15 · 2023: 13 · 2022: 20 · 2021: 19 · 2020: 17 · 2019: 24 · 2018: 16 · 2017: 25 · 2016: 28 · 2015: 22 · 2014: 24 · 2013: 36 · 2012: 37
- FWCI
- 43.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Funders
- Pfizer
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- voriconazole, invasive aspergillosis, antifungal therapy, immunocompromised patients, treatment efficacy, drug safety, pulmonary aspergillosis, cerebral aspergillosis, hematologic malignancies
- MeSH terms
- Acute Disease, Administration, Oral, Adolescent, Adult, Aged, Antifungal Agents, Aspergillosis, Female, Humans, Infusions, Intravenous, Male, Middle Aged, Prospective Studies, Pyrimidines, Triazoles, Treatment Outcome, Voriconazole
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