Engineered bio-adhesive polyhedral oligomeric silsesquioxane hybrid nanoformulation of amphotericin B for prolonged therapy of fungal keratitis
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The organic-inorganic hybrid structure formed by integrating POSS with the PEG-PPG polymer enhances adhesion while effectively mitigating the scouring by eye tears.
“The organic–inorganic hybrid structure formed by integrating POSS with the PEG–PPG polymer enhances adhesion while effectively mitigating the scouring by eye tears [208].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [208]
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“The organic – inorganic hybrid structure formed by integrating POSS with the PEG – PPG polymer enhances adhesion while effectively mitigating the scouring by eye tears [208].”
- Authors
- Han, Y., Xu, C., Shi, H., Yu, F., Zhong, Y., Liu, Z., Loh, X. J., Wu, Y.-L., Li, Z., & Li, C.
- Affiliations
- Xiamen University (CN)
- Chinese Academy of Sciences (CN)
- Agency for Science, Technology and Research (SG)
- Corresponding author
- Wu, Yun-Long
- Li, Zibiao
- Li, Cheng
- ORCID
- Venue
- Chemical Engineering Journal
- Publisher
- Elsevier BV
- Published
- 2021-10
- Volume
- 421
- Pages
- 129734
- ISSN
- 1385-8947 (ISSN-L)
- OpenAlex
- W3155704152
- Cited by
- 30
- References
- 53
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 5
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 195 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Chemical Engineering Journal (acceptedVersion)
- Ningbo Institute of Materials Technology and Engineering, CAS Institutional Repository (submittedVersion)
- Funders
- Agency for Science Technology and Research
- National Natural Science Foundation of China
- National Key Research and Development Program of China Stem Cell and Translational Research
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Keywords
- fungal keratitis, amphotericin B, polyhedral oligomeric silsesquioxane, ocular drug retention, corneal drug delivery, antifungal therapy, mouse model
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