The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Aptasensor with Expanded Nucleotide Using DNA Nanotetrahedra for Electrochemical Detection of Cancerous Exosomes
Open accessAbstract
Exosomes are extracellular vesicles (50-100 nm) circulating in biofluids as intercellular signal transmitters. Although the potential of cancerous exosomes as tumor biomarkers is promising, sensitive and rapid detection of exosomes remains challenging. Herein, we combined the strengths of advanced aptamer technology, DNA-based nanostructure, and portable electrochemical devices to develop a nanotetrahedron (NTH)-assisted aptasensor for direct capture and detection of hepatocellular exosomes. The oriented immobilization of aptamers significantly improved the accessibility of an artificial nucleobase-containing aptamer to suspended exosomes, and the NTH-assisted aptasensor could detect exosomes with 100-fold higher sensitivity when compared to the single-stranded aptamer-functionalized aptasensor. The present study provides a proof-of-concept for sensitive and efficient quantification of tumor-derived exosomes. We thus expect the NTH-assisted electrochemical aptasensor to become a powerful tool for comprehensive exosome studies.
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Cites
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099
Tumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3169 · Cited by 2,692
Cited by
Exosomes as a new frontier of cancer liquid biopsy
Yu, D., Li, Y., Wang, M., Gu, J., Xu, W., Cai, H., Fang, X., & Zhang, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01509-9 · Cited by 855
Liu, C., Zhao, J., Tian, F., Cai, L., Zhang, W., Feng, Q., Chang, J., Wan, F., Yang, Y., Dai, B., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0343-6 · Cited by 482
Self-citationHuang, R., He, L., Xia, Y., Xu, H., Liu, C., Xie, H., Wang, S., Peng, L., Liu, Y., Liu, Y., et al. (2019) · Small · doi:10.1002/smll.201900735 · Cited by 303
Self-citationBiogenesis, Isolation, and Detection of Exosomes and Their Potential in Therapeutics and Diagnostics
Sonbhadra, S., Mehak, & Pandey, L. M. (2023) · Biosensors · doi:10.3390/bios13080802 · Cited by 97
Empowering Exosomes with Aptamers for Precision Theranostics
Zheng, L., Li, J., Li, Y., Sun, W., Ma, L., Qu, F., & Tan, W. (2025) · Small Methods · doi:10.1002/smtd.202400551 · Cited by 21
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Metadata
- Authors
- Wang, S., Zhang, L., Wan, S., Cansiz, S., Cui, C., Liu, Y., Cai, R., Hong, C., Teng, I.-T., Shi, M., Wu, Y., Dong, Y., & Tan, W.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-03-20
- Volume
- 11
- Issue
- 4
- Pages
- 3943-3949
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2596078482
- Cited by
- 476
- References
- 5
- FWCI
- 17.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, S., Zhang, L., Wan, S., Cansiz, S., Cui, C., Liu, Y., Cai, R., Hong, C., Teng, I.-T., Shi, M., Wu, Y., Dong, Y., & Tan, W. (2017). Aptasensor with Expanded Nucleotide Using DNA Nanotetrahedra for Electrochemical Detection of Cancerous Exosomes. ACS Nano. https://doi.org/10.1021/acsnano.7b00373
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