The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
A Sensitive Aptasensor Based on a Hemin/G‐Quadruplex‐Assisted Signal Amplification Strategy for Electrochemical Detection of Gastric Cancer Exosomes
Abstract
Emerging evidence indicates that exosomes derived from gastric cancer cells enhance tumor migration and invasion through the modulation of the tumor microenvironment. However, it remains a major problem to detect cancer‐specific exosomes due to technical and biological challenges. Most of the methods reported could not achieve efficient detection of tumor‐derived exosomes in the background of normal exosomes. Herein, a label‐free electrochemical aptasensor is presented for specific detection of gastric cancer exosomes. This platform contains an anti‐CD63 antibody modified gold electrode and a gastric cancer exosome specific aptamer. The aptamer is linked to a primer sequence that is complementary to a G‐quadruplex circular template. The presence of target exosomes could trigger rolling circle amplification and produce multiple G‐quadruplex units. This horseradish peroxidase mimicking DNAzyme could catalyze the reduction of H 2 O 2 and generate electrochemical signals. This aptasensor exhibits high selectivity and sensitivity toward gastric cancer exosomes with a detection limit of 9.54 × 10 2 mL−1 and a linear response range from 4.8 × 10 3 to 4.8 × 10 6 exosomes per milliliter. Therefore, this electrochemical aptasensor is expected to become a useful tool for the early diagnosis of gastric cancer.
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Cites
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Self-citationThe Exosome Total Isolation Chip
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Cited by
Exosomes as a new frontier of cancer liquid biopsy
Yu, D., Li, Y., Wang, M., Gu, J., Xu, W., Cai, H., Fang, X., & Zhang, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01509-9 · Cited by 855
Biogenesis, Isolation, and Detection of Exosomes and Their Potential in Therapeutics and Diagnostics
Sonbhadra, S., Mehak, & Pandey, L. M. (2023) · Biosensors · doi:10.3390/bios13080802 · Cited by 97
Microfluidic Technology for the Isolation and Analysis of Exosomes
Wu, Y., Wang, Y., Lu, Y., Luo, X., Huang, Y., Xie, T., Pilarsky, C., Dang, Y., & Zhang, J. (2022) · Micromachines · doi:10.3390/mi13101571 · Cited by 91
Analysis of extracellular vesicles as emerging theranostic nanoplatforms
Xing, Y., Cheng, Z., Wang, R., Lv, C., James, T. D., & Yu, F. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213506 · Cited by 67
Metadata
- Authors
- Huang, R., He, L., Xia, Y., Xu, H., Liu, C., Xie, H., Wang, S., Peng, L., Liu, Y., Liu, Y., He, N., & Li, Z.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2019-04-08
- Volume
- 15
- Issue
- 19
- Pages
- e1900735-e1900735
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2938518143
- Cited by
- 303
- References
- 22
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huang, R., He, L., Xia, Y., Xu, H., Liu, C., Xie, H., Wang, S., Peng, L., Liu, Y., Liu, Y., He, N., & Li, Z. (2019). A Sensitive Aptasensor Based on a Hemin/G‐Quadruplex‐Assisted Signal Amplification Strategy for Electrochemical Detection of Gastric Cancer Exosomes. Small. https://doi.org/10.1002/smll.201900735
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