The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Bifunctional Tellurium Nanodots for Photo-Induced Synergistic Cancer Therapy
Abstract
Elemental tellurium (Te) nanoparticles are increasingly important in a variety of applications such as thermoelectricity, photoconductivity, and piezoelectricity. However, they have been explored with limited success in their biomedical use, and thus a tremendous challenge still exists in the exploration of Te nanoparticles that can treat tumors as an effective anticancer agent. Here, we introduce bifunctional Te nanodots with well-defined nanostructure as an effective anticancer agent for photo-induced synergistic cancer therapy with tumor ablation, which is accomplished using hollow albumin nanocages as a nanoreactor. Under near-infrared light irradiation, Te nanodots can produce effective photothermal conversion, as well as highly reactive oxygen species such as •O 2 – and dismutated •OH via a type-I mechanism through direct electron transfer, thereby triggering the potent in vivo hyperthermia and simultaneous intracellular reactive oxygen species at tumors. Moreover, Te nanodots possess perfect resistance to photobleaching, effective cytoplasmic translocation, preferable tumor accumulation, as well as in vivo renal elimination, promoting severe photo-induced cell damage and subsequent synergy between photothermal and photodynamic treatments for tumor ablation. These findings provide the insight of elemental Te nanodots for biomedical research.
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Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
Kratz, F. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.05.010 · Cited by 2,151
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Clinical development and potential of photothermal and photodynamic therapies for cancer
Li, X., Lovell, J. F., Yoon, J., & Chen, X. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0410-2 · Cited by 3,456
Liu, C., Wang, D., Zhang, S., Cheng, Y., Yang, F., Xing, Y., Xu, T., Dong, H., & Zhang, X. (2019) · ACS Nano · doi:10.1021/acsnano.8b09387 · Cited by 641
Inorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications
Zhao, N., Yan, L., Zhao, X., Chen, X., Li, A., Zheng, D., Zhou, X., Dai, X., & Xu, F.-J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00401 · Cited by 429
Precise nanomedicine for intelligent therapy of cancer
Chen, H., Gu, Z., An, H., Chen, C., Chen, J., Cui, R., Chen, S., Chen, W., Chen, X., Chen, X., et al. (2018) · Science China Chemistry · doi:10.1007/s11426-018-9397-5 · Cited by 409
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Metadata
- Authors
- Yang, T., Ke, H., Wang, Q., Tang, Y., Deng, Y., Yang, H., Yang, X., Yang, P., Ling, D., Chen, C., Zhao, Y., Wu, H., & Chen, H.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-10-02
- Volume
- 11
- Issue
- 10
- Pages
- 10012-10024
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2756748061
- Cited by
- 192
- References
- 2
- FWCI
- 9.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, T., Ke, H., Wang, Q., Tang, Y., Deng, Y., Yang, H., Yang, X., Yang, P., Ling, D., Chen, C., Zhao, Y., Wu, H., & Chen, H. (2017). Bifunctional Tellurium Nanodots for Photo-Induced Synergistic Cancer Therapy. ACS Nano. https://doi.org/10.1021/acsnano.7b04230
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