Clinical development and potential of photothermal and photodynamic therapies for cancer

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109 · see citing works

Nanocarriers as an emerging platform for cancer therapy

Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710 · see citing works

Photodynamic therapy for cancer

Dolmans, D. E. J. G. J., Fukumura, D., & Jain, R. K. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1071 · Cited by 6,773 · see citing works

Photodynamic therapy of cancer: An update

Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145 · see citing works

Stimulated Optical Radiation in Ruby

MAIMAN, T. H. (1960) · Nature · doi:10.1038/187493a0 · Cited by 5,121 · see citing works

Photodynamic Therapy

Gomer, C. J. (1988) · Cited by 4,169 · see citing works

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

Fang, J. Q., Nakamura, H., & Maeda, H. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.04.009 · Cited by 3,573 · see citing works

Fluorescence-Guided Surgery with 5-Aminolevulinic Acid for Resection of Malignant Glioma: A Randomised Controlled Multicentre Phase III Trial

Stummer, W., Pichlmeier, U., Meinel, T., Wiestler, O. D., Zanella, F., & Reulen, H.-J. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70665-9 · Cited by 3,423 · see citing works

Nanoparticles in Photodynamic Therapy

Lucky, S. S., Soo, K. C., & Zhang, Y. (2015) · Chemical Reviews · doi:10.1021/cr5004198 · Cited by 2,999 · see citing works

Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Liu, Y., Bhattarai, P., Dai, Z., & Chen, X. S. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00618k · Cited by 2,919 · see citing works

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

Bertrand, N., Wu, J., Xu, X., Kamaly, N., & Farokhzad, O. C. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.009 · Cited by 2,865 · see citing works

Exploiting tumour hypoxia in cancer treatment

Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828 · see citing works

Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics

Chen, G., Qiu, H., Prasad, P. N., & Chen, X. S. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,704 · see citing works

Photodynamic therapy and anti-tumour immunity

Castaño, A. P., Mróz, P., & Hamblin, M. R. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1894 · Cited by 2,685 · see citing works

In vivo near-infrared fluorescence imaging

Frangioni, J. V. (2003) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2003.08.007 · Cited by 2,655 · see citing works

Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization

Celli, J. P., Spring, B. Q., Rizvi, I., Evans, C. L., Samkoe, K. S., Verma, S., Pogue, B. W., & Hasan, T. G. (2010) · Chemical Reviews · doi:10.1021/cr900300p · Cited by 2,334 · see citing works

BODIPY dyes in photodynamic therapy

Kamkaew, A., Lim, S. H., Lee, H. B., Kiew, L. V., Chung, L. Y., & Burgess, K. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35216h · Cited by 2,104 · see citing works

The Heat Shock Response: Life on the Verge of Death

Richter, K., Haslbeck, M., & Büchner, J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.006 · Cited by 2,045 · see citing works

The role of porphyrin chemistry in tumor imaging and photodynamic therapy

Ethirajan, M., Chen, Y., Joshi, P., & Pandey, R. K. (2010) · Chemical Society Reviews · doi:10.1039/b915149b · Cited by 2,038 · see citing works

Activatable Photosensitizers for Imaging and Therapy

Lovell, J. F., Liu, T. W. B., Chen, J., & Zheng, G. (2010) · Chemical Reviews · doi:10.1021/cr900236h · Cited by 1,718 · see citing works

Overcoming the Achilles' heel of photodynamic therapy

Fan, W., Huang, P., & Chen, X. S. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00616g · Cited by 1,686 · see citing works

Nanoshell-Enabled Photothermal Cancer Therapy: Impending Clinical Impact

Lal, S., Clare, S. E., & Halas, N. J. (2008) · Accounts of Chemical Research · doi:10.1021/ar800150g · Cited by 1,627 · see citing works

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

Chen, Q., Xu, L., Liang, C., Wang, C., Peng, R., & Liu, Z. (2016) · Nature Communications · doi:10.1038/ncomms13193 · Cited by 1,600 · see citing works

Organic molecule-based photothermal agents: an expanding photothermal therapy universe

Jung, H. S., Verwilst, P., Sharma, A. K., Shin, J. W., Sessler, J. L., & Kim, J. S. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00522a · Cited by 1,592 · see citing works

Photodynamic therapy with endogenous protoporphyrin

Kennedy, J. C., Pottier, R. H., & Pross, D. C. (1990) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(90)85083-9 · Cited by 1,509 · see citing works

Photoradiation therapy for the treatment of malignant tumors.

Dougherty, T. J., Kaufman, J., Goldfarb, A., Weishaupt, K. R., Boyle, D. G., & Mittleman, A. (1978) · PubMed · Cited by 1,487 · see citing works

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

Danhier, F. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.11.015 · Cited by 1,288 · see citing works

Innovative Strategies for Hypoxic‐Tumor Photodynamic Therapy

Li, X., Kwon, N., Guo, T., Liu, Z., & Yoon, J. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201805138 · Cited by 1,176 · see citing works

Photothermally Enhanced Photodynamic Therapy Delivered by Nano-Graphene Oxide

Tian, B., Wang, C., Zhang, S., Feng, L., & Liu, Z. (2011) · ACS Nano · doi:10.1021/nn201560b · Cited by 1,082 · see citing works

Cancer cell–selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules

Mitsunaga, M., Ogawa, M., Kosaka, N., Rosenblum, L. T., Choyke, P. L., & Kobayashi, H. (2011) · Nature Medicine · doi:10.1038/nm.2554 · Cited by 1,064 · see citing works

Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions

van Straten, D., Mashayekhi, V., de Bruijn, H., Oliveira, S., & Robinson, D. J. (2017) · Cancers · doi:10.3390/cancers9020019 · Cited by 1,023 · see citing works

Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Zhu, S., Tian, R., Antaris, A. L., Chen, X. S., & Dai, H. (2019) · Advanced Materials · doi:10.1002/adma.201900321 · Cited by 968 · see citing works

Photodynamic therapeutics: basic principles and clinical applications

Sharman, W. M., Allen, C. M., & van Lier, J. E. (1999) · Drug Discovery Today · doi:10.1016/s1359-6446(99)01412-9 · Cited by 922 · see citing works

Basic principles, applications in oncology and improved selectivity of photodynamic therapy.

Vrouenraets, M. B., Visser, G. W. M., Snow, G. B., & van Dongen, G. A. M. S. (2003) · PubMed · Cited by 920 · see citing works

A Review of Progress in Clinical Photodynamic Therapy

Huang, Z. W. (2005) · Technology in Cancer Research & Treatment · doi:10.1177/153303460500400308 · Cited by 912 · see citing works

Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study

Rastinehad, A. R., Anastos, H., Wajswol, E., Winoker, J. S., Sfakianos, J. P., Doppalapudi, S. K., Carrick, M. R., Knauer, C. J., Taouli, B. A., Lewis, S. C., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906929116 · Cited by 893 · see citing works

Dye Sensitizers for Photodynamic Therapy

Ormond, A., & Freeman, H. (2013) · Materials · doi:10.3390/ma6030817 · Cited by 847 · see citing works

Photodynamic therapy of cancer. Basic principles and applications

Juarranz, Á., Jaén, P., Sanz-Rodrı́guez, F., Cuevas, J., & González, S. (2008) · Clinical & Translational Oncology · doi:10.1007/s12094-008-0172-2 · Cited by 765 · see citing works

The History of Photodetection and Photodynamic Therapy¶

Ackroyd, R., Kelty, C., Brown, N. J., & Reed, M. (2001) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)0740656thopap2.0.co2 · Cited by 666 · see citing works

Near-infrared optical properties of<i>ex vivo</i>human skin and subcutaneous tissues measured using the Monte Carlo inversion technique

Simpson, C. R., Kohl, M., Essenpreis, M., & Cope, M. (1998) · Physics in Medicine and Biology · doi:10.1088/0031-9155/43/9/003 · Cited by 651 · see citing works

Aggregation-Induced Emission (AIE) Dots: Emerging Theranostic Nanolights

Feng, G., & Liu, B. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.8b00060 · Cited by 649 · see citing works

Ultrasound Triggered Tumor Oxygenation with Oxygen-Shuttle Nanoperfluorocarbon to Overcome Hypoxia-Associated Resistance in Cancer Therapies

Song, X., Feng, L., Liang, C., Yang, K., & Liu, Z. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b02365 · Cited by 581 · see citing works

The Photobiology of Photodynamic Therapy: Cellular Targets and Mechanisms

Oleinick, N. L., & Evans, H. H. (1998) · Radiation Research · doi:10.2307/3579816 · Cited by 571 · see citing works

Clinical development of photodynamic agents and therapeutic applications

Baskaran, R., Lee, J., & Yang, S.-G. (2018) · Biomaterials Research · doi:10.1186/s40824-018-0140-z · Cited by 564 · see citing works

A Core/Satellite Multifunctional Nanotheranostic for in Vivo Imaging and Tumor Eradication by Radiation/Photothermal Synergistic Therapy

Xiao, Q., Zheng, X., Bu, W., Ge, W., Zhang, S., Chen, F., Xing, H., Ren, Q., Fan, W., Zhao, K., et al. (2013) · Journal of the American Chemical Society · doi:10.1021/ja404985w · Cited by 554 · see citing works

Activatable Photosensitizers: Agents for Selective Photodynamic Therapy

Li, X., Kolemen, S., Yoon, J., & Akkaya, E. U. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201604053 · Cited by 544 · see citing works

Photodynamic therapy with porfimer sodium for ablation of high-grade dysplasia in Barrett's esophagus: international, partially blinded, randomized phase III trial

Overholt, B. F., Lightdale, C. J., Wang, K. K., et al. (2005) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2005.06.047 · Cited by 527 · see citing works

Phthalocyanines as medicinal photosensitizers: Developments in the last five years

Li, X., Zheng, B.-D., Peng, X.-H., Li, S.-Z., Ying, J.-W., Zhao, Y., Huang, J., & Yoon, J. (2017) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.08.003 · Cited by 525 · see citing works

Single Continuous Wave Laser Induced Photodynamic/Plasmonic Photothermal Therapy Using Photosensitizer‐Functionalized Gold Nanostars

Wang, S., Huang, P., Nie, L., Xing, R., Liu, D., Wang, Z., Lin, J., Chen, S., Niu, G., Lu, G., et al. (2013) · Advanced Materials · doi:10.1002/adma.201204623 · Cited by 505 · see citing works

Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model

Conde, J., Oliva, N., Zhang, Y., & Artzi, N. (2016) · Nature Materials · doi:10.1038/nmat4707 · Cited by 449 · see citing works

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

Luo, D., Carter, K. A., Miranda, D., & Lovell, J. F. (2016) · Advanced Science · doi:10.1002/advs.201600106 · Cited by 436 · see citing works

Phthalocyanine‐Assembled Nanodots as Photosensitizers for Highly Efficient Type I Photoreactions in Photodynamic Therapy

Li, X., Lee, D., Huang, J., & Yoon, J. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201806551 · Cited by 426 · see citing works

Theranostic Liposomes with Hypoxia-Activated Prodrug to Effectively Destruct Hypoxic Tumors Post-Photodynamic Therapy

Feng, L., Cheng, L., Dong, Z., Tao, D., Barnhart, T. E., Cai, W., Chen, M., & Liu, Z. (2016) · ACS Nano · doi:10.1021/acsnano.6b07525 · Cited by 425 · see citing works

Tumor hypoxia: its impact on cancer therapy

Moulder, J. E., & Rockwell, S. (1987) · Cancer and Metastasis Reviews · doi:10.1007/bf00055376 · Cited by 413 · see citing works

Breaking the depth dependency of phototherapy with Cerenkov radiation and low-radiance-responsive nanophotosensitizers

Kotagiri, N., Sudlow, G. P., Akers, W. J., & Achilefu, S. A. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.17 · Cited by 403 · see citing works

Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles

Gao, Y., Chen, Y., Ji, X., He, X., Yin, Q., Zhang, Z., Shi, J., & Li, Y. (2011) · ACS Nano · doi:10.1021/nn2033105 · Cited by 397 · see citing works

PHOTODYNAMIC THERAPY

Dougherty, T. J. (1993) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1993.tb04990.x · Cited by 394 · see citing works

A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance

He, Q., Gao, Y., Zhang, L., Zhang, Z., Gao, F., Ji, X., Li, Y., & Shi, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.06.066 · Cited by 393 · see citing works

Multifunctional nanoparticles for upconversion luminescence/MR multimodal imaging and magnetically targeted photothermal therapy

Cheng, L., Yang, K., Li, Y., Zeng, X. C., Shao, M., Lee, S., & Liu, Z. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.069 · Cited by 386 · see citing works

Smart pH-Sensitive and Temporal-Controlled Polymeric Micelles for Effective Combination Therapy of Doxorubicin and Disulfiram

Duan, X., Xiao, J., Yin, Q., Zhang, Z., Yu, H., Mao, S., & Li, Y. (2013) · ACS Nano · doi:10.1021/nn4010796 · Cited by 378 · see citing works

Tumor Ablation: Common Modalities and General Practices

Knavel, E. M., & Brace, C. L. (2013) · Techniques in vascular and interventional radiology · doi:10.1053/j.tvir.2013.08.002 · Cited by 368 · see citing works

Cancer‐Associated, Stimuli‐Driven, Turn on Theranostics for Multimodality Imaging and Therapy

Li, X., Kim, J., Yoon, J., & Chen, X. S. (2017) · Advanced Materials · doi:10.1002/adma.201606857 · Cited by 362 · see citing works

Photodynamic Therapy Using Topical Methyl Aminolevulinate vs Surgeryfor Nodular Basal Cell Carcinoma

Rhodes, L. E., de Rie, M. A., Enström, Y., Groves, R. W., Morken, T., Goulden, V., Wong, G. A. E., Grob, J., Varma, S., & Wolf, P. (2004) · Archives of Dermatology · doi:10.1001/archderm.140.1.17 · Cited by 356 · see citing works

A HISTORY OF PHOTODYNAMIC THERAPY

Daniell, M. D., & Hill, J. S. (1991) · Australian and New Zealand Journal of Surgery · doi:10.1111/j.1445-2197.1991.tb00230.x · Cited by 354 · see citing works

Recent Progresses in Phototherapy‐Synergized Cancer Immunotherapy

Ng, C. W., Li, J., & Pu, K. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201804688 · Cited by 352 · see citing works

Padeliporfin vascular-targeted photodynamic therapy versus active surveillance in men with low-risk prostate cancer (CLIN1001 PCM301): an open-label, phase 3, randomised controlled trial

Azzouzi, A.-R., Vincendeau, S., Barret, É., Cicco, A., Kleinclauss, F., van der Poel, H. G., Stief, C. G., Rassweiler, J., Salomon, G., Solsona, E., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30661-1 · Cited by 346 · see citing works

European guidelines for topical photodynamic therapy part 1: treatment delivery and current indications – actinic keratoses, Bowen’s disease, basal cell carcinoma

Morton, C. A., Szeimies, R. ‐., Sidoroff, A., & Braathen, L. R. (2013) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12031 · Cited by 344 · see citing works

Nanostructured Phthalocyanine Assemblies with Protein-Driven Switchable Photoactivities for Biophotonic Imaging and Therapy

Li, X., Kim, C., Lee, D., Lee, D., Chung, H., Kim, G., Heo, S.-H., Kim, C., Hong, K., & Yoon, J. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b05916 · Cited by 343 · see citing works

Photodynamic therapy with porfimer sodium versus thermal ablation therapy with Nd:YAG laser for palliation of esophageal cancer: a multicenter randomized trial

Lightdale, C. J., Heier, S. K., Marcon, N. E., McCaughan, J. S., Gerdes, H., Overholt, B. F., Sivak, M. V., Stiegmann, G. V., & Nava, H. (1995) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(95)70002-1 · Cited by 340 · see citing works

Photodynamic therapy for prostate cancer—a review of current status and future promise

Moore, C. M., Pendsé, D. A., & Emberton, M. (2009) · Nature Clinical Practice Urology · doi:10.1038/ncpuro1274 · Cited by 332 · see citing works

Nanotechnology for Cancer Therapy Based on Chemotherapy

Zhao, C., Cheng, R., Yang, Z., & Tian, Z. (2018) · Molecules · doi:10.3390/molecules23040826 · Cited by 331 · see citing works

Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy

Ni, K., Lan, G., Veroneau, S. S., Duan, X., Song, Y., & Lin, W. (2018) · Nature Communications · doi:10.1038/s41467-018-06655-7 · Cited by 331 · see citing works

Phase II clinical study of photodynamic therapy using mono-l-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung

Kato, H., Furukawa, K., Sato, M., et al. (2003) · Lung Cancer · doi:10.1016/s0169-5002(03)00242-3 · Cited by 325 · see citing works

RGD-Conjugated Dendrimer-Modified Gold Nanorods for in Vivo Tumor Targeting and Photothermal Therapy

Li, Z., Huang, P., Zhang, X., Lin, J., Yang, S., Liu, B., Gao, F., Xi, P., Ren, Q., & Cui, D. (2009) · Molecular Pharmaceutics · doi:10.1021/mp9001415 · Cited by 323 · see citing works

Mechanisms of Resistance to Photodynamic Therapy

Casas, A. G., Venosa, G. M. D., Hasan, T. G., & Batlle, A. M. D. C. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711795843272 · Cited by 323 · see citing works

Photoimmunotherapy: treatment of animal tumors with tumor-specific monoclonal antibody-hematoporphyrin conjugates.

Mew, D., Wat, C.-K., Towers, G. H. N., et al. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.130.3.1473 · Cited by 321 · see citing works

Photodynamic Therapy for Cancer: What's Past is Prologue

Hamblin, M. R. (2020) · Photochemistry and Photobiology · doi:10.1111/php.13190 · Cited by 310 · see citing works

Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease

MORTON, C. A., WHITEHURST, C., MOSELEY, H., MCCOLL, J. H., MOORE, J. V., & MACKIE, R. M. (1996) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1996.d01-1076.x · Cited by 306 · see citing works

Photodynamic therapy vs. cryosurgery of basal cell carcinomas: results of a phase III clinical trial

Wang, I., Bendsøe, N., af Klinteberg, C., Enejder, A. M. K., Andersson‐Engels, S., Svanberg, S. R., & Svanberg, K. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04141.x · Cited by 305 · see citing works

Iron/iron oxide core/shell nanoparticles for magnetic targeting MRI and near-infrared photothermal therapy

Zhou, Z., Sun, Y., Shen, J., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.063 · Cited by 305 · see citing works

Aptamer-Based Tumor-Targeted Drug Delivery for Photodynamic Therapy

Shieh, Y.-A., Yang, S., Wei, M., & Shieh, M. (2010) · ACS Nano · doi:10.1021/nn901374b · Cited by 300 · see citing works

Cutaneous phototoxic occurrences in patients receiving Photofrin®

Dougherty, T. J., Cooper, M. T., & Mang, T. S. (1990) · Lasers in Surgery and Medicine · doi:10.1002/lsm.1900100514 · Cited by 299 · see citing works

5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas

Mahmoudi, K., Garvey, K. L., Bouras, A., Cramer, G. M., Stepp, H. G., Raj, J. G. J., Bozec, D., Busch, T. M., & Hadjipanayis, C. G. (2019) · Journal of Neuro-Oncology · doi:10.1007/s11060-019-03103-4 · Cited by 293 · see citing works

Self-assembled IR780-loaded transferrin nanoparticles as an imaging, targeting and PDT/PTT agent for cancer therapy

Wang, K., Zhang, Y., Wang, J., et al. (2016) · Scientific Reports · doi:10.1038/srep27421 · Cited by 287 · see citing works

Colorectal Carcinoma Metastases in Liver: Laser-induced Interstitial Thermotherapy—Local Tumor Control Rate and Survival Data

Vogl, T. J., Straub, R., Eichler, K., Söllner, O., & Mack, M. G. (2004) · Radiology · doi:10.1148/radiol.2302020646 · Cited by 286 · see citing works

Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy

Yoon, H. Y., Koo, H., Choi, K. Y., Lee, S. J., Kim, K., Kwon, I. C., Leary, J. F., Park, K., Yuk, S. H., Park, J. H., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.016 · Cited by 285 · see citing works

A prospective phase II study on photodynamic therapy with photofrin II for centrally located early-stage lung cancer. The Japan Lung Cancer Photodynamic Therapy Study Group.

Furuse, K., Fukuoka, M., Kato, H., Horai, T., Kubota, K., Kodama, N., Kusunoki, Y., Takifuji, N., Okunaka, T., & Konaka, C. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.10.1852 · Cited by 283 · see citing works

ALA and Photofrin® Fluorescence-guided resection and repetitive PDT in glioblastoma multiforme: a single centre Phase III randomised controlled trial

Eljamel, S., Goodman, C., & Moseley, H. (2007) · Lasers in Medical Science · doi:10.1007/s10103-007-0494-2 · Cited by 278 · see citing works

Mitochondria-based photodynamic anti-cancer therapy

Morgan, J., & Oseroff, A. R. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00126-0 · Cited by 276 · see citing works

A Bifunctional Photosensitizer for Enhanced Fractional Photodynamic Therapy: Singlet Oxygen Generation in the Presence and Absence of Light

Turan, I. S., Yıldız, D., Türksoy, A., Günaydın, G., & Akkaya, E. U. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201511345 · Cited by 275 · see citing works

Self-Assembled Core–Shell Nanoparticles for Combined Chemotherapy and Photodynamic Therapy of Resistant Head and Neck Cancers

He, C., Liu, D., & Lin, W. (2015) · ACS Nano · doi:10.1021/nn506963h · Cited by 274 · see citing works

Molecular photosensitisers for two-photon photodynamic therapy

Bolze, F., Jenni, S., Sour, A., & Heitz, V. (2017) · Chemical Communications · doi:10.1039/c7cc06133a · Cited by 273 · see citing works

A comparative study of the photosensitizing characteristics of some cyanine dyes

Delaey, E. M., van Laar, F., Vos, D. E. D., Kamuhabwa, A. A. R., Jacobs, P. A., & de Witte, P. A. M. (2000) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(00)00021-x · Cited by 271 · see citing works

Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging

Yu, J., Yin, W., Zheng, X., et al. (2015) · Theranostics · doi:10.7150/thno.11802 · Cited by 267 · see citing works

Stimulation of anti-tumor immunity by photodynamic therapy

Mróz, P., Hashmi, J. T., Huang, Y., Lange, N., & Hamblin, M. R. (2010) · Expert Review of Clinical Immunology · doi:10.1586/eci.10.81 · Cited by 262 · see citing works

Laser-photosensitizer assisted immunotherapy: a novel modality for cancer treatment

Chen, W. R., Adams, R. L., Carubelli, R., et al. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)04707-1 · Cited by 258 · see citing works

Use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture.

Gaullier, J., Berg, K., Peng, Q., Anholt, H., Selbo, P. K., Ma, L. W., & Moan, J. E. (1997) · PubMed · Cited by 257 · see citing works

Current evidence and applications of photodynamic therapy in dermatology

Lin, J., & Wan, M. T. (2014) · Clinical, Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s35334 · Cited by 248 · see citing works

A clinical study comparing methyl aminolevulinate photodynamic therapy and surgery in small superficial basal cell carcinoma (8–20 mm), with a 12-month follow-up

Szeimies, R., Ibbotson, S., Murrell, D., Rubel, D., Frambach, Y., De Berker, D., Dummer, R., Kerrouche, N., Villemagne, H., & on behalf of the Excilight Study Group (2008) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2008.02803.x · Cited by 247 · see citing works

Malignant Liver Tumors Treated with MR Imaging–guided Laser-induced Thermotherapy: Experience with Complications in 899 Patients (2,520 lesions)

Vogl, T. J., Straub, R., Eichler, K., et al. (2002) · Radiology · doi:10.1148/radiol.2252011171 · Cited by 233 · see citing works

History of Photodynamic Therapy

Abdel‐Kader, M. H. (2014) · Springer eBooks · doi:10.1007/978-3-642-39629-8_1 · Cited by 231 · see citing works

[35] Role of activated oxygen species in photodynamic therapy

Sharman, W. M., Allen, C. M., & van Lier, J. E. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)19037-8 · Cited by 228 · see citing works

A self-illuminating nanoparticle for inflammation imaging and cancer therapy

Xu, X., An, H., Zhang, D., Tao, H., Dou, Y., Li, X., Huang, J., & Zhang, J. (2019) · Science Advances · doi:10.1126/sciadv.aat2953 · Cited by 228 · see citing works

Photochemical internalisation in drug and gene delivery

Høgset, A. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.08.016 · Cited by 223 · see citing works

Long-term survival after photodynamic therapy for esophageal cancer

Sibille, A., Lambert, R., Souquet, J.-C., Sabben, G., & Descos, F. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90058-6 · Cited by 223 · see citing works

Photodynamic therapy of high grade glioma – long term survival

Stylli, S. S., Kaye, A. H., MacGregor, L., Howes, M., & Rajendra, P. (2005) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2005.01.006 · Cited by 214 · see citing works

Photodynamic therapy (PDT) for malignant brain tumors – Where do we stand?

Quirk, B. J., Brandal, G., Donlon, S., Vera, J. C., Mang, T. S., Foy, A. B., Lew, S. M., Girotti, A. W., Jogal, S., LaViolette, P. S., et al. (2015) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2015.04.009 · Cited by 208 · see citing works

Nucleus‐Targeting Gold Nanoclusters for Simultaneous In Vivo Fluorescence Imaging, Gene Delivery, and NIR‐Light Activated Photodynamic Therapy

Vankayala, R., Kuo, C., Nuthalapati, K., et al. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201502650 · Cited by 208 · see citing works

Designing Photosensitizers for Photodynamic Therapy: Strategies, Challenges and Promising Developments

Garland, M. J., Cassidy, C. M., Woolfson, D., & Donnelly, R. F. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.55 · Cited by 207 · see citing works

Phase III randomized trial of surgery with or without intraoperative photodynamic therapy and postoperative immunochemotherapy for malignant pleural mesothelioma

Pass, H. I., TEMECK, B. K., Kranda, K. C., et al. (1997) · Annals of Surgical Oncology · doi:10.1007/bf02303746 · Cited by 198 · see citing works

mTHPC‐mediated photodynamic therapy for early oral squamous cell carcinoma

Hopper, C., Kübler, A. C., Lewis, H., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20209 · Cited by 196 · see citing works

Photodynamic Therapy for Prostate Cancer Recurrence After Radiotherapy: A Phase I Study

Nathan, T. R., Whitelaw, D., Chang, S. C., et al. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(05)64466-7 · Cited by 193 · see citing works

Interstitial Photodynamic Therapy—A Focused Review

Shafirstein, G., Bellnier, D. A., Oakley, E., Hamilton, S., Potasek, M. J., Beeson, K. W., & Parilov, E. (2017) · Cancers · doi:10.3390/cancers9020012 · Cited by 192 · see citing works

Bifunctional Tellurium Nanodots for Photo-Induced Synergistic Cancer Therapy

Yang, T., Ke, H., Wang, Q., Tang, Y., Deng, Y., Yang, H., Yang, X., Yang, P., Ling, D., Chen, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b04230 · Cited by 192 · see citing works

Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a multicentre, randomized, observer-blind phase III study in comparison with a registered methyl-5-aminolaevulinate cream and placebo

Dirschka, T., Radny, P., Dominicus, R., Mensing, H., Brüning, H., Jenne, L., Karl, L., Sebastian, M., Oster‐Schmidt, C., Klövekorn, W., et al. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10613.x · Cited by 182 · see citing works

mTHPC‐mediated photodynamic therapy in patients with advanced, incurable head and neck cancer: a multicenter study of 128 patients

Dcruz, A. K., Robinson, M. H., & Biel, M. A. (2004) · Head & Neck · doi:10.1002/hed.10372 · Cited by 182 · see citing works

Bio-nanotechnology and photodynamic therapy—State of the art review

Allison, R. R., Mota, H., Bagnato, V. S., & Sibata, C. H. (2008) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2008.02.001 · Cited by 181 · see citing works

Cancer multidrug resistance (MDR): a major impediment to effective chemotherapy.

Ullah, M. F. (2009) · PubMed · Cited by 180 · see citing works

Photodynamic therapy of actinic keratosis with topical 5-aminolevulinic acid. A pilot dose-ranging study

Jeffes, E. W. (1997) · Archives of Dermatology · doi:10.1001/archderm.133.6.727 · Cited by 177 · see citing works

Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy

Li, X., Yu, S., Lee, D., Kim, G., Lee, B., Cho, Y., Zheng, B.-Y., Ke, M., Huang, J., Nam, K. T., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b07809 · Cited by 176 · see citing works

A randomized, multicentre study of directed daylight exposure times of 1½ vs. 2½ h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp

Wiegell, S. R., Fabricius, S., Stender, I., Berne, B., Kroon, S., Andersen, B. L., Mørk, C., Sandberg, C., Jemec, G. B. E., Mogensen, M., et al. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10209.x · Cited by 175 · see citing works

A prospective Phase II clinical trial of 5-aminolevulinic acid to assess the correlation of intraoperative fluorescence intensity and degree of histologic cellularity during resection of high-grade gliomas

Lau, D., Hervey‐Jumper, S. L., Chang, S. M., Molinaro, A. M., McDermott, M. W., Phillips, J. J., & Berger, M. S. (2015) · Journal of neurosurgery · doi:10.3171/2015.5.jns1577 · Cited by 172 · see citing works

Clinical PD/PDT in North America: An historical review

Allison, R. R., Mota, H., & Sibata, C. (2004) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/s1572-1000(04)00084-5 · Cited by 169 · see citing works

Photodynamic therapy: Inception to application in breast cancer

Banerjee, S. M., MacRobert, A. J., Mosse, C. A., Periera, B., Bown, S. G., & Keshtgar, M. (2016) · The Breast · doi:10.1016/j.breast.2016.09.016 · Cited by 169 · see citing works

Enhanced Afterglow Performance of Persistent Luminescence Implants for Efficient Repeatable Photodynamic Therapy

Fan, W., Lu, N., Xu, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b01505 · Cited by 168 · see citing works

Mortality after Esophagectomy: Risk Factor Analysis

Ferguson, M. K., Martin, T. R., Reeder, L. B., et al. (1997) · World Journal of Surgery · doi:10.1007/s002689900279 · Cited by 166 · see citing works

Mechanisms involved in δ-aminolevulinic acid (ALA)-induced photosensitivity of tumor cells: Relation of ferrochelatase and uptake of ALA to the accumulation of protoporphyrin

Ohgari, Y., Nakayasu, Y., Kitajima, S., Sawamoto, M., Mori, H., Shimokawa, O., Matsui, H., & Taketani, S. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.10.019 · Cited by 165 · see citing works

Pyroelectric nanoplatform for NIR-II-triggered photothermal therapy with simultaneous pyroelectric dynamic therapy

Tang, Z., Zhao, P., Ni, D., et al. (2018) · Materials Horizons · doi:10.1039/c8mh00627j · Cited by 165 · see citing works

The place of bronchoscopic photodynamic therapy in advanced unresectable lung cancer: experience of 100 cases1

Moghissi, K., Dixon, K., Stringer, M. R., Freeman, T. L., Thorpe, A., & Brown, S. B. (1999) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(98)00295-4 · Cited by 162 · see citing works

Targeted Nanomaterials for Phototherapy

Chitgupi, U., Qin, Y., & Lovell, J. F. (2016) · Nanotheranostics · doi:10.7150/ntno.17694 · Cited by 162 · see citing works

Nature: A rich source for developing multifunctional agents. tumor‐imaging and photodynamic therapy

Pandey, R. K., Goswami, L. N., Chen, Y., Gryshuk, A., Missert, J. R., Oseroff, A. R., & Dougherty, T. J. (2006) · Lasers in Surgery and Medicine · doi:10.1002/lsm.20352 · Cited by 161 · see citing works

Preliminary safety and efficacy results of laser immunotherapy for the treatment of metastatic breast cancer patients

Li, X., Ferrel, G. L., Guerra, M. C., et al. (2011) · Photochemical & Photobiological Sciences · doi:10.1039/c0pp00306a · Cited by 160 · see citing works

Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease

Morton, C. A., Whitehurst, C., Moseley, H., et al. (1996) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1996.tb03887.x · Cited by 155 · see citing works

Photodynamic Therapy Treatment of Early Oral and Laryngeal Cancers†

Biel, M. A. (2007) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00153.x · Cited by 151 · see citing works

A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity

Li, X., Zheng, B.-Y., Ke, M., Zhang, Y., Huang, J., & Yoon, J. (2017) · Theranostics · doi:10.7150/thno.18861 · Cited by 151 · see citing works

Non-porphyrin photosensitizers in biomedicine

WAINWRIGHT, M. S. (1996) · Chemical Society Reviews · doi:10.1039/cs9962500351 · Cited by 148 · see citing works

Photodynamic Therapy of Actinic Keratosis With Topical 5-Aminolevulinic Acid

Jeffes, E. W. B. (1997) · Archives of Dermatology · doi:10.1001/archderm.1997.03890420065007 · Cited by 141 · see citing works

Low Power Single Laser Activated Synergistic Cancer Phototherapy Using Photosensitizer Functionalized Dual Plasmonic Photothermal Nanoagents

Younis, M. R., Wang, C., An, R., et al. (2019) · ACS Nano · doi:10.1021/acsnano.8b09552 · Cited by 139 · see citing works

Photodynamic Therapy for Early Stage Bronchogenic Carcinoma

Kato, H., Okunaka, T., & Shimatani, H. (1996) · Journal of Clinical Laser Medicine & Surgery · doi:10.1089/clm.1996.14.235 · Cited by 135 · see citing works

Photodynamic therapy in melanoma--an update.

Bâldea, I., & Filip, G. A. (2012) · PubMed · Cited by 130 · see citing works

Results of photodynamic therapy for ablation of dysplasia and early cancer in Barrett's esophagus and effect of oral steroids on stricture formation

Panjehpour, M., Overholt, B. F., Haydek, J. M., & Lee, S. G. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02300.x · Cited by 129 · see citing works

Stereotactic laser ablation of high-grade gliomas

Hawasli, A. H., Kim, A. H., Dunn, G. P., et al. (2014) · Neurosurgical FOCUS · doi:10.3171/2014.9.focus14471 · Cited by 129 · see citing works

Photodynamic therapy as palliation for esophageal cancer: experience in 215 patients

Litle, V. R., Luketich, J. D., Christie, N. A., et al. (2003) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(03)01299-2 · Cited by 128 · see citing works

Randomized, double-blind, prospective study to compare topical 5-aminolaevulinic acid methylester with topical 5-aminolaevulinic acid photodynamic therapy for extensive scalp actinic keratosis

Moloney, F. J., & Collins, P. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.07946.x · Cited by 128 · see citing works

Photodynamic Therapy for Non-Melanoma Skin Cancers

Cohen, D., & Lee, P. (2016) · Cancers · doi:10.3390/cancers8100090 · Cited by 128 · see citing works

Photodynamic Therapy of Head and Neck Cancers

Biel, M. A. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-697-9_18 · Cited by 126 · see citing works

Efficacy and safety of photodynamic therapy versus Nd‐YAG laser resection in NSCLC with airway obstruction

Díaz-Jiménez, J. P., Martínez-Ballarín, J. E., Llunell, A., Farrero, E., Rodríguez, A., & Castro, M. J. (1999) · European Respiratory Journal · doi:10.1034/j.1399-3003.1999.14d13.x · Cited by 126 · see citing works

Nuclear Targeting of Chlorin e6 Enhances Its Photosensitizing Activity

Akhlynina, T. V., Jans, D. A., Rosenkranz, A. A., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20328 · Cited by 124 · see citing works

Revisiting photodynamic therapy dosimetry: reductionist & surrogate approaches to facilitate clinical success

Pogue, B. W., Elliott, J. T., Kanick, S. C., Davis, S. C., Samkoe, K. S., Maytin, E. V., Pereira, S. P., & Hasan, T. G. (2016) · Physics in Medicine and Biology · doi:10.1088/0031-9155/61/7/r57 · Cited by 121 · see citing works

Temoporfin‐mediated photodynamic therapy in patients with advanced, incurable head and neck cancer: A multicenter study

Tan, I. B., Dolivet, G., Céruse, P., et al. (2010) · Head & Neck · doi:10.1002/hed.21368 · Cited by 119 · see citing works

Protoporphyrin IX Fluorescence and Photobleaching During Interstitial Photodynamic Therapy of Malignant Gliomas for Early Treatment Prognosis

Johansson, A., Faber, F., Kniebühler, G., Stepp, H. G., Sroka, R. C., Egensperger, R., Beyer, W., & Kreth, F.-W. (2013) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22126 · Cited by 119 · see citing works

Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization

Berg, K., Nordstrand, S., Selbo, P. K., Tran, D. T. T., Angell‐Petersen, E., & Høgset, A. (2011) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05128h · Cited by 116 · see citing works

Photodynamic Therapy for Lung Cancer and Malignant Pleural Mesothelioma

Simone, C. B., & Cengel, K. A. (2014) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.09.017 · Cited by 113 · see citing works

Role of photodynamic therapy in the treatment of esophageal cancer

Wu, H., Minamide, T., & Yano, T. (2019) · Digestive Endoscopy · doi:10.1111/den.13353 · Cited by 113 · see citing works

Photochemical internalization (PCI) in cancer therapy: From bench towards bedside medicine

Norum, O.-J., Selbo, P. K., Weyergang, A., Giercksky, K.-E., & Berg, K. (2009) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2009.04.012 · Cited by 112 · see citing works

Retinal Photocoagulation by Lasers

Kapany, N. S., Peppers, N. A., Zweng, H. C., et al. (1963) · Nature · doi:10.1038/199146a0 · Cited by 107 · see citing works

Laser ablation of hepatocellular carcinoma-A review

Gough-Palmer, A., & Gedroyc, W. M. W. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.7170 · Cited by 100 · see citing works

Is photodynamic therapy a good alternative to surgery and radiotherapy in the treatment of head and neck cancer?

Nyst, H. J., Tan, I. B., Stewart, F. A., & Balm, A. J. M. (2009) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2009.03.002 · Cited by 100 · see citing works

Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial

Sultan, A. A., Jerjes, W., Berg, K., Høgset, A., Mosse, C. A., Hamoudi, R., Hamdoon, Z., Simeon, C., Carnell, D. M., Forster, M. D., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30224-8 · Cited by 99 · see citing works

Photoacoustic imaging and photothermal therapy in the second near-infrared window

Ge, X., Fu, Q., Bai, L. L., et al. (2019) · New Journal of Chemistry · doi:10.1039/c9nj01402k · Cited by 99 · see citing works

In situ photoimmunotherapy: a tumour-directed treatment for melanoma

Naylor, M. F., Chen, W. R., Teague, T. K., Perry, L., & Nordquist, R. E. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07514.x · Cited by 94 · see citing works

Photodynamic Therapy of Bladder Cancer – A Phase I Study Using Hexaminolevulinate (HAL)

Bader, M. J., Stepp, H. G., Beyer, W., Pongratz, T., Sroka, R. C., Kriegmair, M., Zaak, D., Welschof, M., Derya Tilki, A., Stief, C. G., et al. (2012) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2012.02.007 · Cited by 93 · see citing works

Photodynamic therapy for unresectable cholangiocarcinoma: A comparative effectiveness systematic review and meta-analyses

Leggett, C. L., Gorospe, E. C., Murad, M. H., et al. (2012) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2012.03.002 · Cited by 92 · see citing works

Treatment of Head and Neck Cancer with Photodynamic Therapy with Redaporfin: A Clinical Case Report

Santos, L. L., Oliveira, J., Monteiro, E. F., Santos, J. M. B., & Sarmento, C. (2018) · Case Reports in Oncology · doi:10.1159/000493423 · Cited by 90 · see citing works

Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance

Wang, Z., Ma, R., Yan, L., Chen, X., & Zhu, G. (2015) · Chemical Communications · doi:10.1039/c5cc04376j · Cited by 89 · see citing works

Conjugation of a photosensitizer to near infrared light renewable persistent luminescence nanoparticles for photodynamic therapy

Abdurahman, R., Yang, C., & Yan, X. (2016) · Chemical Communications · doi:10.1039/c6cc07616e · Cited by 89 · see citing works

The cost-effectiveness of Foscan mediated photodynamic therapy (Foscan-PDT) compared with extensive palliative surgery and palliative chemotherapy for patients with advanced head and neck cancer in the UK

Hopper, C., Niziol, C., & Sidhu, M. S. (2003) · Oral Oncology · doi:10.1016/j.oraloncology.2003.09.003 · Cited by 86 · see citing works

Phase I study of photodynamic therapy using talaporfin sodium and diode laser for local failure after chemoradiotherapy for esophageal cancer

Yano, T., Muto, M., Yoshimura, K., et al. (2012) · Radiation Oncology · doi:10.1186/1748-717x-7-113 · Cited by 86 · see citing works

Clinical experience of patients undergoing photodynamic therapy for Barrett's dysplasia or cancer

Wolfsen, H. C., Hemminger, L. L., Wallace, M. B., et al. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02209.x · Cited by 86 · see citing works

Fluorescence‐guided surgery for high‐grade gliomas

Lakomkin, N., & Hadjipanayis, C. G. (2018) · Journal of Surgical Oncology · doi:10.1002/jso.25154 · Cited by 85 · see citing works

Photosensitizers in prostate cancer therapy

Gheewala, T., Skwor, T., & Munirathinam, G. (2017) · Oncotarget · doi:10.18632/oncotarget.15496 · Cited by 84 · see citing works

STRATEGIES FOR SELECTIVE CANCER PHOTOCHEMOTHERAPY: ANTIBODY‐TARGETED and SELECTIVE CARCINOMA CELL PHOTOLYSIS*

Oseroff, A. R., Ara, G., Ohuoha, D., et al. (1987) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1987.tb04740.x · Cited by 83 · see citing works

Photodynamic therapy for peripheral lung cancer

Okunaka, T., Kato, H., Tsutsui, H., et al. (2003) · Lung Cancer · doi:10.1016/j.lungcan.2003.08.016 · Cited by 79 · see citing works

Photodynamic therapy prolongs metal stent patency in patients with unresectable hilar cholangiocarcinoma

Lee, T. Y. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i39.5589 · Cited by 78 · see citing works

Photodynamic Therapy for Barrett's Esophagus and Esophageal Carcinoma

Qumseya, B. J., David, W., & Wolfsen, H. C. (2013) · Clinical Endoscopy · doi:10.5946/ce.2013.46.1.30 · Cited by 75 · see citing works

A C5N2 Nanoparticle Based Direct Nucleus Delivery Platform for Synergistic Cancer Therapy

Chen, W., Liu, J., Wang, Y., Jiang, C., Yu, B., Sun, Z., & Lu, L. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201900884 · Cited by 74 · see citing works

Locally Recurrent Central-Type Early Stage Lung Cancer < 1.0 cm in Diameter After Complete Remission by Photodynamic Therapy

Furukawa, K., Kato, H., Konaka, C., et al. (2005) · CHEST Journal · doi:10.1378/chest.128.5.3269 · Cited by 73 · see citing works

On the Evolution of Some Endoscopic Light Delivery Systems for Photodynamic Therapy

van den Bergh, H. (1998) · Endoscopy · doi:10.1055/s-2007-1001289 · Cited by 73 · see citing works

A randomized, multinational, noninferiority, phase III trial to evaluate the safety and efficacy of BF-200 aminolaevulinic acid gel vs. methyl aminolaevulinate cream in the treatment of nonaggressive basal cell carcinoma with photodynamic therapy

Morton, C. A., Dominicus, R., Radny, P., Dirschka, T., Hauschild, A., Reinhold, U., Aschoff, R., Ulrich, M., Keohane, S. G., Ekanayake‐Bohlig, S., et al. (2018) · British Journal of Dermatology · doi:10.1111/bjd.16441 · Cited by 72 · see citing works

Photodynamic therapy in head and neck cancer: indications, outcomes, and future prospects

Meulemans, J., Delaere, P., & Poorten, V. V. (2019) · Current Opinion in Otolaryngology & Head & Neck Surgery · doi:10.1097/moo.0000000000000521 · Cited by 72 · see citing works

Laser neurosurgery: A systematic analysis of magnetic resonance-guided laser interstitial thermal therapies

Lagman, C., Chung, L. K., Pelargos, P. E., et al. (2016) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2016.10.019 · Cited by 71 · see citing works

Complications of Laser Ablation for Hepatocellular Carcinoma: A Multicenter Study

Arienti, V., Pretolani, S., Pacella, C. M., et al. (2008) · Radiology · doi:10.1148/radiol.2463070390 · Cited by 70 · see citing works

Sequential Protein-Responsive Nanophotosensitizer Complex for Enhancing Tumor-Specific Therapy

Li, X., Fan, H., Guo, T., Bai, H., Kwon, N., Kim, K. H., Yu, S., Cho, Y., Kim, H., Nam, K. T., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b01100 · Cited by 70 · see citing works

Talaporfin sodium

Wang, S., Bromley, E., Xu, L., Chen, J. C., & Keltner, L. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560903463893 · Cited by 70 · see citing works

A comparison of hexaminolevulinate (Hexvix®) fluorescence cystoscopy and white-light cystoscopy for detection of bladder cancer: results of the HeRo observational study

Lapini, A., Minervini, A., Masala, A., et al. (2012) · Surgical Endoscopy · doi:10.1007/s00464-012-2387-0 · Cited by 69 · see citing works

Consensus recommendations on the use of daylight photodynamic therapy with methyl aminolevulinate cream for actinic keratoses in A ustralia

See, J., Shumack, S. P., Murrell, D. F., Rubel, D. M., Fernández‐Peñas, P., Salmon, R., Hewitt, D., Foley, P. A., & Spelman, L. J. (2015) · Australasian Journal of Dermatology · doi:10.1111/ajd.12354 · Cited by 65 · see citing works

Selective Photothermal Tumor Therapy Using Nanodiamond‐Based Nanoclusters with Folic Acid

Ryu, T., Baek, S. W., Kang, R. H., & Choi, S. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201601207 · Cited by 65 · see citing works

Daylight Photodynamic Therapy for Actinic Keratoses

Morton, C. A., & Braathen, L. R. (2018) · American Journal of Clinical Dermatology · doi:10.1007/s40257-018-0360-y · Cited by 65 · see citing works

The Surgical Palliation of Advanced Head and Neck Cancer using Photodynamic Therapy

Jerjes, W., Upile, T., Akram, S., et al. (2010) · Clinical Oncology · doi:10.1016/j.clon.2010.07.001 · Cited by 62 · see citing works

An update on the regulatory status of PDT photosensitizers in China

Huang, Z. W. (2008) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2009.01.005 · Cited by 60 · see citing works

PD/PDT for gynecological disease: A clinical review

Allison, R. R., Cuenca, R. E., Downie, G., Randall, M. E., Bagnato, V. S., & Sibata, C. H. (2005) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/s1572-1000(05)00033-5 · Cited by 60 · see citing works

Photodynamic therapy in superficial bladder cancer: past, present and future

Jichlinski, P., & Leisinger, H. (2001) · Urological Research · doi:10.1007/s002400100215 · Cited by 59 · see citing works

Laser ablation as focal therapy for prostate cancer

Wenger, H., Yousuf, A. N., Oto, A., et al. (2014) · Current Opinion in Urology · doi:10.1097/mou.0000000000000044 · Cited by 59 · see citing works

A RANDOMIZED COMPARATIVE STUDY OF THE SAFETY and EFFICACY OF PHOTODYNAMIC THERAPY USING PHOTOFRIN II COMBINED WITH PALLIATIVE RADIOTHERAPY VERSUS PALLIATIVE RADIOTHERAPY ALONE IN PATIENTS WITH INOPERABLE OBSTRUCTIVE NON‐SMALL CELL BRONCHOGENIC CARCINOMA

Lam, S. C., Kostashuk, E. C., Coy, E. P., et al. (1987) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1987.tb04865.x · Cited by 58 · see citing works

Photodynamic Therapy for Pancreatic Cancer

Fan, B., & Andrén‐Sandberg, Å. (2007) · Pancreas · doi:10.1097/mpa.0b013e3180439c50 · Cited by 56 · see citing works

A clinical review of PDT for cutaneous malignancies

Allison, R. R., Sibata, C. H., Downie, G., & Cuenca, R. E. (2006) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2006.05.002 · Cited by 54 · see citing works

Phase 2 Open-Label Trial Investigating Percutaneous Laser Ablation for Treatment of Early-Stage Breast Cancer: MRI, Pathology, and Outcome Correlations

Schwartzberg, B. S., Lewin, J., Abdelatif, O., Bernard, J., Bu-Ali, H., Cawthorn, S., Chen-Seetoo, M., Feldman, S. M., Govindarajulu, S., Jones, L. I., et al. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-6623-2 · Cited by 53 · see citing works

Light distribution and calibration of commercial PDT LED arrays

Moseley, H. (2005) · Photochemical & Photobiological Sciences · doi:10.1039/b507325a · Cited by 52 · see citing works

5-Aminolevulinic acid in intraoperative photodynamic therapy of bladder cancer (results of multicenter trial)

Филоненко, Е. В., Каприн, А. Д., Alekseev, B. Y., et al. (2016) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2016.09.009 · Cited by 52 · see citing works

Promotion of Proapoptotic Signals by Lysosomal Photodamage

Kessel, D. H., & Reiners, J. J. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12456 · Cited by 51 · see citing works

Targeting drugs to tumours using cell membrane-coated nanoparticles

Fang, R. H., Gao, W., & Zhang, L. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00699-x · Cited by 980 · see citing works

Phototherapy in cancer treatment: strategies and challenges

Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453 · see citing works

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

Gunaydin, G., Gedik, M. E., & Ayan, S. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.686303 · Cited by 402 · see citing works

Singlet Oxygen, Photodynamic Therapy, and Mechanisms of Cancer Cell Death

Maharjan, P. S., & Bhattarai, H. K. (2022) · Journal of Oncology · doi:10.1155/2022/7211485 · Cited by 222 · see citing works

Pyroptosis‐Mediated Synergistic Photodynamic and Photothermal Immunotherapy Enabled by a Tumor‐Membrane‐Targeted Photosensitive Dimer

Tang, Y., Bisoyi, H. K., Chen, X., Liu, Z., Chen, X., Zhang, S., & Li, Q. (2023) · Advanced Materials · doi:10.1002/adma.202300232 · Cited by 214 · see citing works

Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms

Songca, S. P., & Adjei, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063209 · Cited by 175 · see citing works

Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents

Ma, D., Bian, H., Gu, M., Wang, L., Chen, X., & Peng, X. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215677 · Cited by 124 · see citing works

Dynamic Adjust of Non‐Radiative and Radiative Attenuation of AIE Molecules Reinforces NIR‐II Imaging Mediated Photothermal Therapy and Immunotherapy

Wang, Z., Yu, L., Wang, Y., Wang, C., Mu, Q., Liu, X., Yu, M., Wang, K., Yao, G., & Yu, Z. (2022) · Advanced Science · doi:10.1002/advs.202104793 · Cited by 125 · see citing works

Neutral Cyanine: Ultra‐Stable NIR‐II Merocyanines for Highly Efficient Bioimaging and Tumor‐Targeted Phototheranostics

Wan, Y., Chen, W., Liu, Y., Lee, K., Gao, Y., Zhang, D., Li, Y., Huang, Z., Luo, J., Lee, C., et al. (2024) · Advanced Materials · doi:10.1002/adma.202405966 · Cited by 90 · see citing works

Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy

Zhu, L., Song, G., Zhang, W., Wu, Y., Chen, Y., Song, J., Wang, D., Li, G., Tang, B. Z., & Li, Y. (2025) · Nature Communications · doi:10.1038/s41467-025-57533-y · Cited by 63 · see citing works

Chemiluminescence in Combination with Organic Photosensitizers: Beyond the Light Penetration Depth Limit of Photodynamic Therapy

Gao, J., Chen, Z., Li, X., Yang, M., Lv, J., Li, H., & Yuan, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012556 · Cited by 61 · see citing works

Near‐Infrared‐II Fluorophore with Inverted Dependence of Fluorescence Quantum Yield on Polarity as Potent Phototheranostics for Fluorescence‐Image‐Guided Phototherapy of Tumors

Li, M., Lu, Z., Zhang, J., Chen, L., Tang, X., Jiang, Q., Hu, Q., Li, L., Liu, J., & Huang, W. (2023) · Advanced Materials · doi:10.1002/adma.202209647 · Cited by 56 · see citing works

Recent advances in near-infrared-II organic J-aggregates for bio-applications

Xu, J., Zheng, X., Ren, T.-B., Shi, L., Yin, X., Yuan, L., & Zhang, X.-B. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216379 · Cited by 48 · see citing works

When near-infrared fluorescence meets supramolecular coordination complexes: Challenges and opportunities of metallacycles/metallacages in precision biomedicine

Xu, Y., Dou, Y., Li, Q., Ye, H., Li, Y., Qiu, S., Xiong, X., Li, J., & Sun, Y. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215320 · Cited by 39 · see citing works

A comparative study between conventional chemotherapy and photothermal activated nano-sized targeted drug delivery to solid tumor

Kiani Shahvandi, M., Souri, M., Tavasoli, S., Moradi Kashkooli, F., Kar, S., & Soltani, M. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107574 · Cited by 37 · see citing works

A minimalist and robust chemo-photothermal nanoplatform capable of augmenting autophagy-modulated immune response against breast cancer

Ming, H., Li, B., Tian, H., Zhou, L., Jiang, J., Zhang, T., Qiao, L., Wu, P., Nice, E. C., Zhang, W., et al. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100289 · Cited by 33 · see citing works

Optimized indocyanine green nanopreparations for biomedical applications

Xia, W.-L., Ran, X.-Y., Xie, K.-P., Zhao, Y., Chen, J., Zhou, Q., Yu, X.-Q., & Li, K. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216422 · Cited by 33 · see citing works

Recent Progress in Extracellular Vesicle-Based Carriers for Targeted Drug Delivery in Cancer Therapy

Tang, Y., Liu, X., Sun, M., Xiong, S., Xiao, N., Li, J., He, X., & Xie, J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071902 · Cited by 24 · see citing works

Recent advances on the construction of long-wavelength emissive supramolecular coordination complexes for photo-diagnosis and therapy

Zhang, Z., Ye, H., Cai, F., & Sun, Y. (2023) · Dalton Transactions · doi:10.1039/d3dt01893h · Cited by 17 · see citing works

Glutathione-Depleted Photodynamic Nanoadjuvant for Triggering Nonferrous Ferroptosis to Amplify Radiotherapy of Breast Cancer

Shi, J., Cui, G., Jin, Y., Mi, B., Liu, K., Zhao, L., Bao, K., Lu, Z., Liu, J., Wang, Y., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202402474 · Cited by 18 · see citing works

Organic small-molecule NIR-II fluorophores for tumor phototheranostics

Xiang, D., Wang, Z., Zheng, H., Tang, Y., & Li, Q. (2026) · Light: Science &amp; Applications · doi:10.1038/s41377-026-02212-w · Cited by 22 · see citing works

Modulation of hypoxia and redox in the solid tumor microenvironment with a catalytic nanoplatform to enhance combinational chemodynamic/sonodynamic therapy

Liu, Y., Wang, L., Wei, F., Tian, Y., Mou, J., Yang, S., & Wu, H. (2023) · Biomaterials Science · doi:10.1039/d2bm01251k · Cited by 16 · see citing works

Metal‐Bridging Cyclic Bilatriene Analogue Affords Stable π‐Radicaloid Dyes with Near‐Infrared II Absorption

Ghosh, A., Mori, S., Ide, Y., Song, J. T., Yamaoka, Y., Ishihara, T., Ikeue, T., Furuta, H., & Ishida, M. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202418751 · Cited by 14 · see citing works

Near-infrared II theranostic agents for the diagnosis and treatment of Alzheimer’s disease

Zhou, C., Zeng, F., Yang, H., Liang, Z., Xu, G., Li, X., Liu, X., & Yang, J. (2024) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-024-06690-1 · Cited by 14 · see citing works

Pharmaceutical development, composition and quantitative analysis of phthalocyanine as the photosensitizer for cancer photodynamic therapy

Zhou, J., Shao, J., Yang, T., et al. (2013) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2013.05.014 · Cited by 156 · see citing works

Carbon Nanotubes for Cancer Therapy

Gmeiner, W. H. (2011) · Nanotechnologies for the Life Sciences · doi:10.1002/9783527610419.ntls0239 · Cited by 1 · see citing works

Development of water-soluble sono/photo-sensitive nanopartices for cancer treatment

Meng, Y., Zou, C., Huang, M., et al. (2010) · doi:10.1109/iscas.2010.5537376

Photodynamic Therapy: A Cancer Treatment for the 21st Century

Durkin, S. (1999) · Gastroenterology Nursing · doi:10.1097/00001610-199905000-00003 · Cited by 1 · see citing works

Photodynamic Therapy and Hyperthermia in Combination Treatment—Neglected Forces in the Fight against Cancer

Bienia, A., Wiecheć-Cudak, O., Murzyn, A. A., & Krzykawska-Serda, M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081147 · Cited by 60 · see citing works