The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase-Encapsulated Therapeutic Metal Phenolic Nanoparticles
Abstract
This study applies in situ production of hypochlorous acid (HOCl) to improve the therapeutic efficacy of platinum drugs. The phagocytic enzyme myeloperoxidase (MPO) is coated with two functional polyphenol derivatives (platinum prodrug polyphenols and PEG polyphenols) and ferric ion by metal phenolic coordination, which can shield MPO from degradation by other compounds in the blood. Moreover, the platinum prodrug can be reduced to cisplatin in cells and produce hydrogen peroxide (H 2 O 2 ). The MPO catalyzes the conversion of H 2 O 2 to HOCl in the intercellular environment. The as-prepared MPO Pt PEG nanoparticles (MPP NPs) can be employed as a reactive oxygen species cascade bioreaction to enhance platinum drug therapy. The MPP NPs show prolonged blood circulation and high tumor accumulation as evidenced by 89 Zr-based positron emission tomography imaging. The MPP NPs effectively inhibit tumor growth in vivo . As a first-in-class platform to harness the highly toxic HOCl in nanomedicine for cancer therapy, this strategy may open doors for further development of progressive therapeutic systems.
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Cites
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452
Nox3, a superoxide-generating nadph oxidase of the inner ear
Bánfi, B., Malgrange, B., Knisz, J., Steger, K., Dubois-Dauphin, M., & Krause, K.-H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403046200 · Cited by 467
Enhancing tumor penetration of nanomedicines
Sun, Q., Ojha, T., Kiessling, F., Lammers, T., & Shi, Y. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00068 · Cited by 198
Cited by
Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery
Guo, Y., Sun, Q., Wu, F., Dai, Y., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202007356 · Cited by 650
Self-citationEngineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer
Zhang, F., Li, F., Lu, G.-H., Nie, W., Zhang, L., Lv, Y., Bao, W., Gao, X., Wei, W., Pu, K., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b00892 · Cited by 357
Nanocatalysts-augmented Fenton chemical reaction for nanocatalytic tumor therapy
Qian, X., Zhang, J., Gu, Z., & Chen, Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.04.023 · Cited by 331
Metal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts
Ma, L., Jiang, F., Fan, X., Wang, L., He, C., Zhou, M., Li, S., Luo, H., Cheng, C., & Qiu, L. (2020) · Advanced Materials · doi:10.1002/adma.202003065 · Cited by 298
Wang, S., Wang, Z., Yu, G., Zhou, Z., Jacobson, O., Liu, Y., Ma, Y., Zhang, F., Chen, Z., & Chen, X. (2019) · Advanced Science · doi:10.1002/advs.201801986 · Cited by 292
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Metadata
- Authors
- Dai, Y., Cheng, S., Wang, Z., Zhang, R., Yang, Z., Wang, J., Yung, B. C., Wang, Z., Jacobson, O., Xu, C., Ni, Q., Yu, G., Zhou, Z., & Chen, X.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-01-05
- Volume
- 12
- Issue
- 1
- Pages
- 455-463
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2781824095
- Cited by
- 172
- References
- 3
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dai, Y., Cheng, S., Wang, Z., Zhang, R., Yang, Z., Wang, J., Yung, B. C., Wang, Z., Jacobson, O., Xu, C., Ni, Q., Yu, G., Zhou, Z., & Chen, X. (2018). Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase-Encapsulated Therapeutic Metal Phenolic Nanoparticles. ACS Nano. https://doi.org/10.1021/acsnano.7b06852
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