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Cited by 195

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Copper Silicate Hollow Microspheres-Incorporated Scaffolds for Chemo-Photothermal Therapy of Melanoma and Tissue Healing

Open access
Yu, Qingqing, Han, Yiming, Wang, Xiaocheng, Qin, Chen, Zhai, Dong, Yi, Zhengfang, Chang, Jiang, Xiao, Yin, Wu, Chengtie·2018·ACS Nano

Abstract

The treatment of melanoma requires complete removal of tumor cells and simultaneous tissue regeneration of tumor-initiated cutaneous defects. Herein, copper silicate hollow microspheres (CSO HMSs)-incorporated bioactive scaffolds were designed for chemo-photothermal therapy of skin cancers and regeneration of skin tissue. CSO HMSs were synthesized with interior hollow and external nanoneedle microstructure, showing excellent drug-loading capacity and photothermal effects. With incorporation of drug-loaded CSO HMSs into the electrospun scaffolds, the composite scaffolds exhibited excellent photothermal effects and controlled NIR-triggered drug release, leading to distinctly synergistic chemo-photothermal therapy of skin cancer both in vitro and in vivo. Furthermore, such CSO HMSs-incorporated scaffolds could promote proliferation and attachment of normal skin cells and accelerate skin tissue healing in tumor-bearing and diabetic mice. Taken together, CSO HMSs-incorporated scaffolds may be used for complete eradication of the remaining tumor cells after surgery and simultaneous tissue healing, which offers an effective strategy for therapy and regeneration of tumor-initiated tissue defects.

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Crossref · 10.1021/acsnano.7b08928

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Metadata

Authors
Yu, Q., Han, Y., Wang, X., Qin, C., Zhai, D., Yi, Z., Chang, J., Xiao, Y., & Wu, C.
Venue
ACS Nano
Published
2018-03-08
Volume
12
Issue
3
Pages
2695-2707
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
OpenAlex
W2789641767
Cited by
195
References
2
FWCI
9.72
Type
journal article
Language
en
Open access
green

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