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π-Extended Benzoporphyrin-Based Metal–Organic Framework for Inhibition of Tumor Metastasis
Abstract
We report on the benzoporphyrin-based metal–organic framework (TBP-MOF), with 10-connected Zr 6 cluster and much improved photophysical properties over the traditional porphyrin-based MOFs. It was found that TBP-MOF exhibited red-shifted absorption bands and strong near-infrared luminescence for bioimaging, whereas the π-extended benzoporphyrin-based linkers of TBP-MOF facilitated 1 O 2 generation to enhance O 2 -dependent photodynamic therapy (PDT). It was demonstrated that poly(ethylene glycol)-modified nanoscale TBP-MOF (TBP-nMOF) can be used as an effective PDT agent under hypoxic tumor microenvironment. We also elucidated that the low O 2 -dependent PDT of TBP-nMOF in combination with αPD-1 checkpoint blockade therapy can not only suppress the growth of primary tumor, but also stimulate an antitumor immune response for inhibiting metastatic tumor growth. We believe this TBP-nMOF has great potential to serve as an efficient photosensitizer for PDT and cancer immunotherapy.
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Cited by
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Zhuang, W.-R., Wang, Y., Cui, P.-F., Xing, L., Lee, J., Kim, D., Jiang, H.-L., & Oh, Y.-K. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.014 · Cited by 508
Precise nanomedicine for intelligent therapy of cancer
Chen, H., Gu, Z., An, H., Chen, C., Chen, J., Cui, R., Chen, S., Chen, W., Chen, X., Chen, X., et al. (2018) · Science China Chemistry · doi:10.1007/s11426-018-9397-5 · Cited by 409
Self-citationA Mn(III)-Sealed Metal–Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics
Wan, S.-S., Cheng, Q., Zeng, X., & Zhang, X.-Z. (2019) · ACS Nano · doi:10.1021/acsnano.9b00300 · Cited by 322
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Lan, G., Ni, K., Veroneau, S. S., Feng, X., Nash, G. T., Luo, T., Xu, Z., & Lin, W. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b13804 · Cited by 317
Metadata
- Authors
- Zeng, J.-Y., Zou, M.-Z., Zhang, M., Wang, X.-S., Zeng, X., Cong, H., & Zhang, X.-Z.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-03-27
- Volume
- 12
- Issue
- 5
- Pages
- 4630-4640
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2794968257
- Cited by
- 160
- References
- 0
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zeng, J.-Y., Zou, M.-Z., Zhang, M., Wang, X.-S., Zeng, X., Cong, H., & Zhang, X.-Z. (2018). π-Extended Benzoporphyrin-Based Metal–Organic Framework for Inhibition of Tumor Metastasis. ACS Nano. https://doi.org/10.1021/acsnano.8b01186
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