The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
A Mn(III)-Sealed Metal–Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics
Abstract
Here, a Mn(III)-sealed metal-organic framework (MOF) nanosystem based on coordination between Mn(III) and porphyrin (TCPP) via a one-pot method was designed and constructed. Mn(III), as a sealer, not only quenched TCPP-based fluorescence but also inhibited reactive oxygen species (ROS) generation, which made MOFs an "inert" theranostic nanoparticle. Interestingly, upon endocytosis by tumor cells, MOFs were disintegrated into Mn(II) and free TCPP by intracellular glutathione (GSH) in tumor cells, owing to redox reaction between Mn(III) and GSH. This disintegration would lead to consumption of antioxidant GSH and activated Mn(II)-based magnetic resonance imaging (MRI) as well as TCPP-based fluorescent imaging. More importantly, such a GSH-regulated TCPP release could implement controllable ROS generation under irradiation, which avoided side effects (inflammation and damage of normal tissues). As a consequence, after unlocking by GSH, Mn(III)-sealed MOFs could significantly improve the therapeutic efficiency of photodynamic therapy by combining controlled ROS generation and GSH depletion after precise dual tumor homing.
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Cites
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Photodynamic therapy for cancer
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Photodynamic therapy and anti-tumour immunity
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Association of reactive oxygen species levels and radioresistance in cancer stem cells
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Intracellular Glutathione Detection Using MnO2-Nanosheet-Modified Upconversion Nanoparticles
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Cited by
Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121110 · Cited by 1,168
Multifunctional metal–organic framework heterostructures for enhanced cancer therapy
Liu, J., Huang, J., Zhang, L., & Lei, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00178c · Cited by 285
Stimuli responsive nanosonosensitizers for sonodynamic therapy
Jiang, Z., Xiao, W., & Fu, Q. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.08.003 · Cited by 173
Glutathione-responsive and -exhausting metal nanomedicines for robust synergistic cancer therapy
Liu, P., Hao, L., Liu, M., & Hu, S. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1161472 · Cited by 58
Metadata
- Authors
- Wan, S.-S., Cheng, Q., Zeng, X., & Zhang, X.-Z.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-05-28
- Volume
- 13
- Issue
- 6
- Pages
- 6561-6571
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2946949749
- Cited by
- 322
- References
- 32
- FWCI
- 13.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wan, S.-S., Cheng, Q., Zeng, X., & Zhang, X.-Z. (2019). A Mn(III)-Sealed Metal–Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics. ACS Nano. https://doi.org/10.1021/acsnano.9b00300
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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