The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Soft Conducting Polymer Hydrogels Cross-Linked and Doped by Tannic Acid for Spinal Cord Injury Repair
Abstract
Mimicking soft tissue mechanical properties and the high conductivity required for electrical transmission in the native spinal cord is critical in nerve tissue regeneration scaffold designs. However, fabricating scaffolds of high conductivity, tissue-like mechanical properties, and excellent biocompatibility simultaneously remains a great challenge. Here, a soft, highly conductive, biocompatible conducting polymer hydrogel (CPH) based on a plant-derived polyphenol, tannic acid (TA), cross-linking and doping conducting polypyrrole (PPy) chains is developed to explore its therapeutic efficacy after a spinal cord injury (SCI). The developed hydrogels exhibit an excellent electronic conductivity (0.05-0.18 S/cm) and appropriate mechanical properties (0.3-2.2 kPa), which can be achieved by controlling TA concentration. In vitro, a CPH with a higher conductivity accelerated the differentiation of neural stem cells (NSCs) into neurons while suppressing the development of astrocytes. In vivo, with relatively high conductivity, the CPH can activate endogenous NSC neurogenesis in the lesion area, resulting in significant recovery of locomotor function. Overall, our findings evidence that the CPHs without being combined with any other therapeutic agents have stimulated tissue repair following an SCI and thus have important implications for future biomaterial designs for SCI therapy.
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Cites
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Cited by
Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications
Bashir, S., Hina, M., Iqbal, J., Rajpar, A. H., Mujtaba, M. A., Alghamdi, N. A., Wageh, S., Ramesh, K., & Ramesh, S. (2020) · Polymers · doi:10.3390/polym12112702 · Cited by 1,160
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Self-citationPolyphenol scaffolds in tissue engineering
Zhang, X., Li, Z., Yang, P., Duan, G., Liu, X., Gu, Z., & Li, Y. (2021) · Materials Horizons · doi:10.1039/d0mh01317j · Cited by 417
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Self-citationCheng, T., Zhang, Y., Wang, S., Chen, Y., Gao, S., Wang, F., Lai, W., & Huang, W. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202101303 · Cited by 308
Metadata
- Authors
- Zhou, L., Fan, L., Yi, X., Zhou, Z., Liu, C., Fu, R., Dai, C., Wang, Z., Chen, X., Yu, P., Chen, D., Tan, G., Wang, Q., & Ning, C.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-10-04
- Volume
- 12
- Issue
- 11
- Pages
- 10957-10967
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2895422828
- Cited by
- 391
- References
- 37
- FWCI
- 14.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhou, L., Fan, L., Yi, X., Zhou, Z., Liu, C., Fu, R., Dai, C., Wang, Z., Chen, X., Yu, P., Chen, D., Tan, G., Wang, Q., & Ning, C. (2018). Soft Conducting Polymer Hydrogels Cross-Linked and Doped by Tannic Acid for Spinal Cord Injury Repair. ACS Nano. https://doi.org/10.1021/acsnano.8b04609
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