The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Exosomes‐Loaded Electroconductive Hydrogel Synergistically Promotes Tissue Repair after Spinal Cord Injury via Immunoregulation and Enhancement of Myelinated Axon Growth
Open accessAbstract
Electroconductive hydrogels are very attractive candidates for accelerated spinal cord injury (SCI) repair because they match the electrical and mechanical properties of neural tissue. However, electroconductive hydrogel implantation can potentially aggravate inflammation, and hinder its repair efficacy. Bone marrow stem cell‐derived exosomes (BMSC‐exosomes) have shown immunomodulatory and tissue regeneration effects, therefore, neural tissue‐like electroconductive hydrogels loaded with BMSC‐exosomes are developed for the synergistic treatment of SCI. These exosomes‐loaded electroconductive hydrogels modulate microglial M2 polarization via the NF‐κ B pathway, and synergistically enhance neuronal and oligodendrocyte differentiation of neural stem cells (NSCs) while inhibiting astrocyte differentiation, and also increase axon outgrowth via the PTEN/PI3K/AKT/mTOR pathway. Furthermore, exosomes combined electroconductive hydrogels significantly decrease the number of CD68‐positive microglia, enhance local NSCs recruitment, and promote neuronal and axonal regeneration, resulting in significant functional recovery at the early stage in an SCI mouse model. Hence, the findings of this study demonstrate that the combination of electroconductive hydrogels and BMSC‐exosomes is a promising therapeutic strategy for SCI repair.
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Astrocyte barriers to neurotoxic inflammation
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Cited by
Yang, W., Kang, X., Gao, X., Zhuang, Y., Fan, C., Shen, H., Chen, Y., & Dai, J. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202211340 · Cited by 188
Xia, Y., Zhu, J., Yang, R., Wang, H., Li, Y., & Fu, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1141601 · Cited by 87
Li, Q., Fu, X., Kou, Y., & Han, N. (2023) · Theranostics · doi:10.7150/thno.84971 · Cited by 63
Liu, X., Zhang, J., Cheng, X., Liu, P., Feng, Q., Wang, S., Li, Y., Gu, H., Zhong, L., Chen, M., et al. (2023) · Regenerative Biomaterials · doi:10.1093/rb/rbac085 · Cited by 58
Self-citationMimicked Spinal Cord Fibers Trigger Axonal Regeneration and Remyelination after Injury
Chen, Z., Sun, Z., Fan, Y., Yin, M., Jin, C., Guo, B., Yin, Y., Quan, R., Zhao, S., Han, S., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c09892 · Cited by 48
Metadata
- Authors
- Fan, L., Liu, C., Chen, X., Zheng, L., Zou, Y., Wen, H., Guan, P., Lu, F., Luo, Y., Tan, G., Yu, P., Chen, D., Deng, C., Sun, Y., Zhou, L., & Ning, C.
- Venue
- Advanced Science
- Publisher
- Wiley
- Published
- 2022-03-06
- Volume
- 9
- Issue
- 13
- Pages
- e2105586-e2105586
- ISSN
- 2198-3844 (ISSN-L)
- OpenAlex
- W4221109630
- Cited by
- 401
- References
- 60
- FWCI
- 47.21
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Exosomes‐Loaded Electroconductive Hydrogel Synergistically Promotes Tissue Repair after Spinal Cord Injury via Immunoregulation and Enhancement of Myelinated Axon Growth. https://app.cochat.ai/papers/10.1002/advs.202105586
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- Fan, L., Liu, C., Chen, X., Zheng, L., Zou, Y., Wen, H., Guan, P., Lu, F., Luo, Y., Tan, G., Yu, P., Chen, D., Deng, C., Sun, Y., Zhou, L., & Ning, C. (2022). Exosomes‐Loaded Electroconductive Hydrogel Synergistically Promotes Tissue Repair after Spinal Cord Injury via Immunoregulation and Enhancement of Myelinated Axon Growth. Advanced Science. https://doi.org/10.1002/advs.202105586
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