The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy
Abstract
Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep-tissue and highly spatiotemporally precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen ( 1 O 2 ) generation efficiency and large two-photon absorption (2PA) cross-sections are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that the polymerization of small-molecule PSs with aggregation-induced emission (AIE) could yield conjugated polymer PSs with good brightness, high 1 O 2 generation efficiency, and large 2PA cross-sections. A pair of conjugated polymer PSs were designed and synthesized, and the corresponding AIE PS dots were prepared by nanoprecipitation, which exhibited outstanding 2PE-PDT performance in in vitro cancer cell ablation and in vivo zebrafish liver tumor treatment. Our work highlights a strategy to design highly efficient PSs for 2PE-PDT.
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Cites
Strategies to Enhance the Photosensitization: Polymerization and the Donor–Acceptor Even–Odd Effect
Liu, S., Zhang, H., Li, Y., Liu, J., Du, L., Chen, M., Kwok, R. T. K., Lam, J. W. Y., Phillips, D. L., & Tang, B. Z. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201810326 · Cited by 277
Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications
Cai, X., & Liu, B. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202000845 · Cited by 796
Self-citationOvercoming barriers in photodynamic therapy harnessing nano-formulation strategies
Xie, J., Wang, Y., Choi, W., Jangili, P., Ge, Y., Xu, Y., Kang, J., Liu, L., Zhang, B., Xie, Z., et al. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01370f · Cited by 522
Self-citationAggregation‐enhanced theranostics: AIE sparkles in biomedical field
Kang, M., Zhang, Z., Song, N., Li, M., Sun, P., Chen, X., Wang, D., & Tang, B. Z. (2020) · Aggregate · doi:10.1002/agt2.7 · Cited by 485
Organic photosensitizers for antimicrobial phototherapy
Nguyen, V.-N., Zhao, Z., Tang, B. Z., & Yoon, J. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00647a · Cited by 462
Metadata
- Authors
- Wang, S., Wu, W., Manghnani, P., Xu, S., Wang, Y., Goh, C. C., Ng, L. G., & Liu, B.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-02-14
- Volume
- 13
- Issue
- 3
- Pages
- 3095-3105
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2911675580
- Cited by
- 236
- References
- 1
- FWCI
- 25.53
- Type
- journal article
- Language
- en
- Open access
- closed
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