Strategies to Enhance the Photosensitization: Polymerization and the Donor–Acceptor Even–Odd Effect
Open accessAbstract
A particular challenge in the design of organic photosensitizers (PSs) with donor–acceptor (D‐A) structures is that it is based on trial and error rather than specific rules. Now these challenges are addressed by proposing two efficient strategies to enhance the photosensitization efficiency: polymerization‐facilitated photosensitization and the D‐A even–odd effect. Conjugated polymers have been found to exhibit a higher 1 O 2 generation efficiency than their small molecular counterparts. Furthermore, PSs with A‐D‐A structures show enhanced photosensitization efficiency over those with D‐A‐D structures. Theoretical calculations suggest an enhanced intersystem crossing (ISC) efficiency by these strategies. Both in vitro and in vivo experiments demonstrate that the resulting materials can be used as photosensitizers in image‐guided photodynamic anticancer therapy. These guidelines are applicable to other polymers and small molecules to lead to the development of new PSs.
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- Authors
- Liu, S., Zhang, H., Li, Y., Liu, J., Du, L., Chen, M., Kwok, R. T. K., Lam, J. W. Y., Phillips, D. L., & Tang, B. Z.
- Affiliations
- Hong Kong University of Science and Technology (HK)
- Jiangsu University (CN)
- University of Hong Kong (HK)
- Corresponding author
- Tang, Ben Zhong
- ORCID
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2018-10-22
- Volume
- 57
- Issue
- 46
- Pages
- 15189-15193
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2892959454
- Cited by
- 277
- References
- 46
- Citations by year
- 2026: 20 · 2025: 33 · 2024: 28 · 2023: 37 · 2022: 49 · 2021: 48 · 2020: 44 · 2019: 18
- FWCI
- 20.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Natural Science Foundation of China (21788102, 21490570, 21490574)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- organic photosensitizers, conjugated polymers, singlet oxygen generation, image-guided photodynamic therapy, photosensitizer design
- MeSH terms
- Animals, HeLa Cells, Humans, Mice, Inbred BALB C, Neoplasms, Photochemotherapy, Polymers, Photosensitizing Agents, Singlet Oxygen, Cell Line, Tumor, Polymerization, Optical Imaging
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