The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Comparing Current Noise in Biological and Solid-State Nanopores
Open accessAbstract
Abstract Nanopores bear great potential as single-molecule tools for bioanalytical sensing and sequencing, due to their exceptional sensing capabilities, high-throughput, and low cost. The detection principle relies on detecting small differences in the ionic current as biomolecules traverse the nanopore. A major bottleneck for the further progress of this technology is the noise that is present in the ionic current recordings, because it limits the signal-to-noise ratio (SNR) and thereby the effective time resolution of the experiment. Here, we review the main types of noise at low and high frequencies and discuss the underlying physics. Moreover, we compare biological and solid-state nanopores in terms of the SNR, the important figure of merit, by measuring translocations of a short ssDNA through a selected set of nanopores under typical experimental conditions. We find that SiNx solid-state nanopores provide the highest SNR, due to the large currents at which they can be operated and the relatively low noise at high frequencies. However, the real game-changer for many applications is a controlled slowdown of the translocation speed, which for MspA was shown to increase the SNR > 160-fold. Finally, we discuss practical approaches for lowering the noise for optimal experimental performance and further development of the nanopore technology.
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Cites
In situ click chemistry generation of cyclooxygenase-2 inhibitors
Bhardwaj, A., Kaur, J., Wuest, M., & Wuest, F. (2017) · Nature Communications · doi:10.1038/s41467-016-0009-6 · Cited by 7,448
Thermal Agitation of Electric Charge in Conductors
Nyquist, H. (1928) · Physical Review · doi:10.1103/physrev.32.110 · Cited by 3,115
Shot noise in mesoscopic conductors
Blanter, Y. M., & Büttiker, M. (2000) · Physics Reports · doi:10.1016/s0370-1573(99)00123-4 · Cited by 2,560
(1995) · Springer eBooks · doi:10.1007/978-1-4419-1229-9 · Cited by 2,526
Structure of Staphylococcal α-Hemolysin, a Heptameric Transmembrane Pore
Song, L., Hobaugh, M. R., Shustak, C., Cheley, S., Bayley, H., & Gouaux, J. E. (1996) · Science · doi:10.1126/science.274.5294.1859 · Cited by 2,377
Limb proportions show developmental plasticity in response to embryo movement
Pollard, A. S., Charlton, B. G., Hutchinson, J. R., Gustafsson, T., McGonnell, I. M., Timmons, J. A., & Pitsillides, A. A. (2017) · Scientific Reports · doi:10.1038/srep41926 · Cited by 2,364
Dekker, C. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.27 · Cited by 1,933
Self-citationAncient DNA and the rewriting of human history: be sparing with Occam’s razor
Haber, M., Mezzavilla, M., Xue, Y., & Tyler-Smith, C. (2016) · Genome Biology · doi:10.1186/s13059-015-0866-z · Cited by 1,924
Nanopore sequencing and assembly of a human genome with ultra-long reads
Jain, M., Koren, S., Miga, K. H., Quick, J., Rand, A. C., Sasani, T. A., Tyson, J. R., Beggs, A. D., Dilthey, A. T., Fiddes, I. T., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4060 · Cited by 1,892
Thermal Agitation of Electricity in Conductors
Johnson, J. B. (1928) · Physical Review · doi:10.1103/physrev.32.97 · Cited by 1,811
Metadata
- Authors
- Fragasso, A., Schmid, S., & Dekker, C.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-02-12
- Volume
- 14
- Issue
- 2
- Pages
- 1338-1349
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W3006545642
- Cited by
- 258
- References
- 80
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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