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Electrospun Biomimetic Fibrous Scaffold from Shape Memory Polymer of PDLLA-co-TMC for Bone Tissue Engineering
Abstract
Multifunctional fibrous scaffolds, which combine the capabilities of biomimicry to the native tissue architecture and shape memory effect (SME), are highly promising for the realization of functional tissue-engineered products with minimally invasive surgical implantation possibility. In this study, fibrous scaffolds of biodegradable poly(d,l-lactide-co-trimethylene carbonate) (denoted as PDLLA-co-TMC, or PLMC) with shape memory properties were fabricated by electrospinning. Morphology, thermal and mechanical properties as well as SME of the resultant fibrous structure were characterized using different techniques. And rat calvarial osteoblasts were cultured on the fibrous PLMC scaffolds to assess their suitability for bone tissue engineering. It is found that by varying the monomer ratio of DLLA:TMC from 5:5 to 9:1, fineness of the resultant PLMC fibers was attenuated from ca. 1500 down to 680 nm. This also allowed for readily modulating the glass transition temperature Tg (i.e., the switching temperature for actuating shape recovery) of the fibrous PLMC to fall between 19.2 and 44.2 °C, a temperature range relevant for biomedical applications in the human body. The PLMC fibers exhibited excellent shape memory properties with shape recovery ratios of Rr > 94% and shape fixity ratios of Rf > 98%, and macroscopically demonstrated a fast shape recovery (∼10 s at 39 °C) in the pre-deformed configurations. Biological assay results corroborated that the fibrous PLMC scaffolds were cytocompatible by supporting osteoblast adhesion and proliferation, and functionally promoted biomineralization-relevant alkaline phosphatase expression and mineral deposition. We envision the wide applicability of using the SME-capable biomimetic scaffolds for achieving enhanced efficacy in repairing various bone defects (e.g., as implants for healing bone screw holes or as barrier membranes for guided bone regeneration).
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Cites
A review on polymer nanofibers by electrospinning and their applications in nanocomposites
Huang, Z.-M., Zhang, Y.-Z., Kotaki, M., & Ramakrishna, S. (2003) · Composites Science and Technology · doi:10.1016/s0266-3538(03)00178-7 · Cited by 7,556
Self-citationThe effect of processing variables on the morphology of electrospun nanofibers and textiles
Deitzel, J. M., Kleinmeyer, J., Harris, D., & Beck Tan, N. C. (2001) · Polymer · doi:10.1016/s0032-3861(00)00250-0 · Cited by 2,915
Pal, M., Pal, U., Jiménez, J. M. G. Y., & Pérez-Rodríguez, F. (2012) · Nanoscale Research Letters · doi:10.1186/1556-276x-7-1 · Cited by 2,620
Lendlein, A., & Kelch, S. (2002) · Kirk-Othmer Encyclopedia of Chemical Technology · doi:10.1002/0471238961.1908011612051404.a01 · Cited by 2,566
Electrospinning of Polymeric Nanofibers for Tissue Engineering Applications: A Review
Pham, Q. P., Sharma, U., & Mikos, A. G. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.1197 · Cited by 2,256
Biodegradable, Elastic Shape-Memory Polymers for Potential Biomedical Applications
Lendlein, A., & Langer, R. (2002) · Science · doi:10.1126/science.1066102 · Cited by 2,146
A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering
Yoshimoto, H., Shin, Y. M., Terai, H., & Vacanti, J. P. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00635-x · Cited by 1,977
Review of progress in shape-memory polymers
Liu, C., Qin, H., & Mather, P. T. (2007) · Journal of Materials Chemistry · doi:10.1039/b615954k · Cited by 1,942
STEIN, G. S., & LIAN, J. B. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-4-424 · Cited by 1,078
Recent advances in shape memory polymers and composites: a review
Ratna, D., & Karger-Kocsis, J. (2008) · Journal of Materials Science · doi:10.1007/s10853-007-2176-7 · Cited by 942
Zhang, Y., Venugopal, J. R., El-Turki, A., Ramakrishna, S., Su, B., & Lim, C. T. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.07.038 · Cited by 702
Self-citationYakacki, C. M., Shandas, R., Lanning, C., Rech, B., Eckstein, A., & Gall, K. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.01.030 · Cited by 618
Water-driven programmable polyurethane shape memory polymer: Demonstration and mechanism
Huang, W. M., Yang, B., An, L., Li, C., & Chan, Y. S. (2005) · Applied Physics Letters · doi:10.1063/1.1880448 · Cited by 616
Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers
Fujihara, K., Kotaki, M., & Ramakrishna, S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.09.014 · Cited by 605
Electrospun nanostructured scaffolds for bone tissue engineering
Prabhakaran, M. P., Venugopal, J., & Ramakrishna, S. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.05.007 · Cited by 430
Shape Memory Assisted Self-Healing Coating
Luo, X., & Mather, P. T. (2013) · ACS Macro Letters · doi:10.1021/mz400017x · Cited by 412
Anderson, H. C., Sipe, J. B., Hessle, L., Dhamyamraju, R., Atti, E., Camacho, N. P., & Millán, J. L. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63172-0 · Cited by 364
Osteoblasts isolated from mouse calvaria initiate matrix mineralization in culture.
Ecarot-Charrier, B., Glorieux, F. H., van der Rest, M., & Pereira, G. (1983) · The Journal of cell biology · doi:10.1083/jcb.96.3.639 · Cited by 359
VASP dynamics during lamellipodia protrusion
Rottner, K., Behrendt, B., Small, J. V., & Wehland, J. (1999) · Nature Cell Biology · doi:10.1038/13040 · Cited by 331
Chatterjee, K., Lin-Gibson, S., Wallace, W. E., Parekh, S. H., Lee, Y. J., Cicerone, M. T., Young, M. F., & Simon, C. G. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.024 · Cited by 309
Cold hibernated elastic memory foams for endovascular interventions
Metcalfe, A., Desfaits, A.-C., Salazkin, I., Yahia, L., Sokolowski, W. M., & Raymond, J. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00362-9 · Cited by 307
Laser-activated shape memory polymer intravascular thrombectomy device
Small IV, W., Wilson, T. S., Benett, W. J., Loge, J. M., & Maitland, D. J. (2005) · Optics Express · doi:10.1364/opex.13.008204 · Cited by 265
Pêgo, A. P., Van Luyn, M. J. A., Brouwer, L. A., van Wachem, P. B., Poot, A. A., Grijpma, D. W., & Feijen, J. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10121 · Cited by 257
Zheng, F., Wang, S., Wen, S., Shen, M., Zhu, M., & Shi, X. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.10.071 · Cited by 255
Evaluation of a degradable shape-memory polymer network as matrix for controlled drug release
Wischke, C., Neffe, A. T., Steuer, S., & Lendlein, A. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.05.027 · Cited by 248
Dynamic cell behavior on shape memory polymer substrates
Davis, K. A., Burke, K. A., Mather, P. T., & Henderson, J. H. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.12.006 · Cited by 238
Ravichandran, R., Venugopal, J. R., Sundarrajan, S., Mukherjee, S., & Ramakrishna, S. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.030 · Cited by 238
Extracellular matrix regenerated: tissue engineering via electrospun biomimetic nanofibers
Sell, S., Barnes, C., Smith, M., McClure, M., Madurantakam, P., Grant, J., McManus, M., & Bowlin, G. (2007) · Polymer International · doi:10.1002/pi.2344 · Cited by 228
Guo, B., Chen, Y., Lei, Y., Zhang, L., Zhou, W. Y., Rabie, A. B. M., & Zhao, J. (2011) · Biomacromolecules · doi:10.1021/bm2000378 · Cited by 189
Biodegradable stents with elastic memory
Venkatraman, S. S., Tan, L. P., Joso, J. F. D., Boey, Y. C. F., & Wang, X. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2005.09.002 · Cited by 178
Biodegradable elastomeric scaffolds for soft tissue engineering
Pêgo, A. P., Poot, A. A., Grijpma, D. W., & Feijen, J. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00351-6 · Cited by 175
Neuss, S., Blomenkamp, I., Stainforth, R., Boltersdorf, D., Jansen, M., Butz, N., Perez-Bouza, A., & Knüchel, R. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.027 · Cited by 151
Shape-memory-actuated change in scaffold fiber alignment directs stem cell morphology
Tseng, L.-F., Mather, P. T., & Henderson, J. H. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.06.043 · Cited by 150
Remotely actuated shape memory effect of electrospun composite nanofibers
Gong, T., Li, W., Chen, H., Wang, L., Shao, S., & Zhou, S. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.12.006 · Cited by 147
High performance shape memory polymer networks based on rigid nanoparticle cores
Xu, J., & Song, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912481107 · Cited by 129
Zhang, Y., Venugopal, J. R., Wong, S. Y., Xu, L., Su, B., Ramakrishna, S., & Lim, C. T. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0221 · Cited by 129
Self-citationLendlein, A., Zotzmann, J., Feng, Y., Alteheld, A., & Kelch, S. (2009) · Biomacromolecules · doi:10.1021/bm900038e · Cited by 115
Xue, L., Dai, S., & Li, Z. (2009) · Macromolecules · doi:10.1021/ma802437f · Cited by 106
Andronova, N., & Albertsson, A.-C. (2006) · Biomacromolecules · doi:10.1021/bm060081c · Cited by 103
Shape Memory Behavior of Novel ( l -Lactide−Glycolide−Trimethylene Carbonate) Terpolymers
Zini, E., Scandola, M., Dobrzyński, P., Kasperczyk, J., & Bero, M. (2007) · Biomacromolecules · doi:10.1021/bm700773s · Cited by 102
Ravichandran, R., Ng, C. C., Liao, S., et al. (2011) · Biomedical Materials · doi:10.1088/1748-6041/7/1/015001 · Cited by 101
Baker, R. M., Henderson, J. H., & Mather, P. T. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20810a · Cited by 96
Development of novel aligned nanofibrous composite membranes for guided bone regeneration
Kharaziha, M., Fathi, M., & Edris, H. (2013) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2013.03.025 · Cited by 94
ATP-mediated mineralization of MC3T3-E1 osteoblast cultures
Nakano, Y., Addison, W. N., & Kaartinen, M. T. (2007) · Bone · doi:10.1016/j.bone.2007.06.011 · Cited by 90
SHAPE-DEFINING SCAFFOLDS FOR MINIMALLY INVASIVE TISSUE ENGINEERING
Thornton, A. J., Alsberg, E., Albertelli, M. A., & Mooney, D. J. (2004) · Transplantation · doi:10.1097/01.tp.0000131152.71117.0e · Cited by 90
Yang, J. H., Liu, F., Liu, Y., & Li, S. (2009) · European Polymer Journal · doi:10.1016/j.eurpolymj.2009.12.017 · Cited by 80
Dallmeyer, I., Chowdhury, S., & Kadla, J. F. (2013) · Biomacromolecules · doi:10.1021/bm400465p · Cited by 76
Ortega, J. M., Small, W., Wilson, T. S., Benett, W. J., Loge, J. M., & Maitland, D. J. (2007) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2007.892927 · Cited by 72
Bao, M., Zhou, Q., Dong, W., Lou, X., & Zhang, Y. (2013) · Biomacromolecules · doi:10.1021/bm4003464 · Cited by 70
Self-citationAn annulus fibrosus closure device based on a biodegradable shape-memory polymer network
Sharifi, S., van Kooten, T. G., Kranenburg, H. C., Meij, B. P., Behl, M., Lendlein, A., & Grijpma, D. W. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.061 · Cited by 68
Inorganic–Organic Shape Memory Polymer (SMP) Foams with Highly Tunable Properties
Zhang, D., Petersen, K. M., & Grunlan, M. A. (2012) · ACS Applied Materials & Interfaces · doi:10.1021/am302426e · Cited by 56
Structural studies of the mineral phase of calcifying cartilage
Rey, C. C., Beshah, K., Griffin, R. G., & Glimcher, M. J. (1991) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650060514 · Cited by 56
Study on the shape memory effects of poly(l-lactide-co-ε-caprolactone) biodegradable polymers
Lu, X., Sun, Z., Cai, W., & Gao, Z. (2007) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-006-0100-3 · Cited by 54
Regulation of electrospun scaffold stiffness via coaxial core diameter
Drexler, J. W., & Powell, H. M. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.10.025 · Cited by 53
Matsumoto, H., Ishiguro, T., Konosu, Y., Minagawa, M., Tanioka, A., Richau, K., Kratz, K. L., & Lendlein, A. (2012) · European Polymer Journal · doi:10.1016/j.eurpolymj.2012.07.008 · Cited by 52
Electrospun shape memory film with reversible fibrous structure
Chen, H., Cao, X., Zhang, J., Zhang, J., Ma, Y., Shi, G., Ke, Y., Tong, D., & Jiang, L. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm33970f · Cited by 46
Guo, W., Kang, H., Chen, Y., Guo, B., & Zhang, L. (2012) · ACS Applied Materials & Interfaces · doi:10.1021/am300828u · Cited by 45
Shape-Memory Properties and Degradation Behavior of Multifunctional Electro-Spun Scaffolds
Kratz, K. L., Habermann, R., Becker, T., Richau, K., & Lendlein, A. (2011) · The International Journal of Artificial Organs · doi:10.5301/ijao.2011.6404 · Cited by 42
Study of the thermal properties of shape memory polyurethane nanofibrous nonwoven
Zhuo, H., Hu, J., & Chen, S. (2011) · Journal of Materials Science · doi:10.1007/s10853-011-5251-z · Cited by 41
Gerber, I., & Gwynn, I. A. (2001) · European Cells and Materials · doi:10.22203/ecm.v002a02 · Cited by 41
The effect of growth factor environment on fibroblast morphological response to substrate stiffness
Grinnell, F., & Ho, C.-H. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.10.036 · Cited by 37
Microfiber SMPU film affords quicker shape recovery than the bulk one
Zhang, J., Ma, Y.-M., Zhang, J., Xu, D. Y., Yang, Q., Guan, J., Cao, X., & Jiang, L. (2011) · Materials Letters · doi:10.1016/j.matlet.2011.06.083 · Cited by 36
Effects of hydrolysis on a new biodegradable co-polymer
Asplund, B., Sperens, J., Mathisen, T., & Hilborn, J. G. (2006) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856206777346331 · Cited by 34
Shape-Memory and Shape-Changing Polymers
Yakacki, C. M. (2013) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/15583724.2012.752745 · Cited by 28
Anisotropic Shape‐Memory Elastomeric Composites: Fabrication and Testing
Rodriguez, E. D., Weed, D. C., & Mather, P. T. (2013) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201300086 · Cited by 24
Growth and Differentiation of Osteoblast‐Like Cells from Calvaria of Connexin43 Deficient Mice
Wiemann, M., Gramsch, B., Winterhager, E., & Schirrmacher, K. (2004) · Materialwissenschaft und Werkstofftechnik · doi:10.1002/mawe.200400833 · Cited by 3
Bao, M., Tu, H., Zhou, Q., Dong, W., & Zhang, Y. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.268 · Cited by 2
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Yu, W., Maynard, E., Chiaradia, V., Arno, M. C., & Dove, A. P. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00883 · Cited by 355
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Metadata
- Authors
- Bao, M., Lou, X., Zhou, Q., Dong, W., Yuan, H., & Zhang, Y.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-02-07
- Volume
- 6
- Issue
- 4
- Pages
- 2611-2621
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W1965652739
- Cited by
- 267
- References
- 67
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- closed
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