Resilient Bioresorbable Copolymers Based on Trimethylene Carbonate, l-Lactide, and 1,5-Dioxepan-2-one
Abstract
The new combinations of monomers presented in this work were evaluated in order to create an elastic material for potential application in soft tissue engineering. Thermoplastic elastomers (TPE) of trimethylene carbonate (TMC) with L-lactide (LLA) and 1,5-dioxepan-2-one (DXO) have been synthesized using a cyclic five-membered tin alkoxide initiator. The block copolymers were designed in such a way that poly(trimethylene carbonate-co-1,5-dioxepan-2-one) formed an amorphous middle block and the poly(L-lactide) (PLLA) formed semicrystalline terminal blocks. The amorphous middle block consisted of relatively randomly distributed TMC and DXO monomer units, and the defined block structure of the PLLA terminal segments was confirmed by 13C NMR. The properties of the TMC-DXO-LLA copolymers were compared with those of triblock copolymers based either on LLA-TMC or on LLA-DXO. Differential scanning calorimetry and dynamic mechanical analysis data confirmed the micro-phase separation in the copolymers. The mechanical properties of the copolymers were evaluated using tensile testing and cycling loading. All of the copolymers synthesized showed a highly elastic behavior. The properties of copolymers could be tailored by altering the proportions of the different monomers.
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Degradable analogues composed of poly(lactide) as hard A blocks and an amorphous aliphatic polyester homopolymer or statistical copolymer as the soft B block have been investigated.
“Inspired by the incredible versatility of styrenic ABA triblock polymers, we and others have investigated degradable analogues composed of poly(lactide) (PLA) as the hard ' A ' blocks and an amorphous aliphatic polyester homopolymer 7 -17 or statistical copolymer 18,19 as the soft ' B ' block.”
From Aliphatic Polyester Block Polymer Design (2016) · cites this paper as [19]
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- Authors
- Andronova, N., & Albertsson, A.-C.
- Affiliations
- KTH Royal Institute of Technology (SE)
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-04-13
- Volume
- 7
- Issue
- 5
- Pages
- 1489-1495
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2028071402
- Cited by
- 103
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 9 · 2012: 6
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomacromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer composites and self-healing
- Keywords
- trimethylene carbonate, L-lactide, thermoplastic elastomers, block copolymers, soft tissue engineering, microphase separation, elastic properties, cyclic loading, monomer composition
- MeSH terms
- Biocompatible Materials, Chlorobenzenes, Dioxanes, Elasticity, Heterocyclic Compounds, Kinetics, Magnetic Resonance Spectroscopy, Polyesters, Stress, Mechanical, Tensile Strength, Elastomers
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