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Lipid-AuNPs@PDA Nanohybrid for MRI/CT Imaging and Photothermal Therapy of Hepatocellular Carcinoma
Abstract
Multifunctional theranostic nanoparticles represent an emerging agent with the potential to offer extremely sensitive diagnosis and targeted cancer therapy. Herein, we report the synthesis and characterization of a multifunctional theranostic agent (referred to as LA-LAPNHs) for targeted magnetic resonance imaging/computed X-ray tomography (MRI/CT) dual-mode imaging and photothermal therapy of hepatocellular carcinoma. The LA-LAPNHs were characterized as having a core-shell structure with the gold nanoparticles (AuNPs)@polydopamine (PDA) as the inner core, the indocyanine green (ICG), which is electrostatically absorbed onto the surface of PDA, as the photothermal therapeutic agent, and the lipids modified with gadolinium-1,4,7,10-tetraacetic acid and lactobionic acid (LA), which is self-assembled on the outer surface as the shell. The LA-LAPNHs could be selectively internalized into the hepatocellular cell line (HepG2 cells) but not into HeLa cells due to the specific recognition ability of LA to asialoglycoprotein receptor. Additionally, the dual-mode imaging ability of the LA-LAPNH aqueous solution was confirmed by enhanced MR and CT imaging showing a shorter T1 relaxation time and a higher Hounsfield unit value, respectively. In addition, the LA-LAPNHs showed significant photothermal cytotoxicity against liver cancer cells with near-infrared irradiation due to their strong absorbance in the region between 700 and 850 nm. In summary, this study demonstrates that LA-LAPNHs may be a promising candidate for targeted MR/CT dual-mode imaging and photothermal therapy of hepatocellular carcinoma.
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Liu, Y., Ai, K., & Lu, L. (2014) · Chemical Reviews · doi:10.1021/cr400407a · Cited by 4,794
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Ryu, J., Ku, S. H., Lee, H., & Park, C. B. (2010) · Advanced Functional Materials · doi:10.1002/adfm.200902347 · Cited by 778
Polydopamine-Based Simple and Versatile Surface Modification of Polymeric Nano Drug Carriers
Park, J., Brust, T. F., Lee, H. J., Lee, S. C., Watts, V. J., & Yeo, Y. (2014) · ACS Nano · doi:10.1021/nn405809c · Cited by 407
Cited by
Zhang, D., Wu, M., Zeng, Y., Wu, L., Wang, Q., Han, X., Liu, X., & Liu, J. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b01027 · Cited by 356
Self-citationInorganic nanoparticles: A potential cancer therapy for human welfare
Pugazhendhi, A., Edison, T. N. J. I., Karuppusamy, I., & Kathirvel, B. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.01.034 · Cited by 325
Recent advances in different modal imaging-guided photothermal therapy
Chen, Q., Wen, J., Li, H., Xu, Y., Liu, F., & Sun, S. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.08.022 · Cited by 265
Multifunctional Bismuth Selenide Nanocomposites for Antitumor Thermo-Chemotherapy and Imaging
Li, Z., Hu, Y., Howard, K. A., Jiang, T., Fan, X., Miao, Z., Sun, Y., Besenbacher, F., & Yu, M. (2016) · ACS Nano · doi:10.1021/acsnano.5b06259 · Cited by 264
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Metadata
- Authors
- Zeng, Y., Zhang, D., Wu, M., Liu, Y., Zhang, X., Li, L., Li, Z., Han, X., Wei, X., & Liu, X.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-08-12
- Volume
- 6
- Issue
- 16
- Pages
- 14266-14277
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2032602686
- Cited by
- 163
- References
- 3
- FWCI
- 8.77
- Type
- journal article
- Language
- en
- Open access
- closed
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