The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Ratiometric Fluorescent Probe Based on ESIPT and AIE Processes for Alkaline Phosphatase Activity Assay and Visualization in Living Cells
Abstract
Alkaline phosphatase (ALP) activity is regarded as an important biomarker in medical diagnosis. A ratiometric fluorescent probe is developed based on a phosphorylated chalcone derivative for ALP activity assay and visualization in living cells. The probe is soluble in water and emits greenish-yellow in aqueous buffers. In the presence of ALP, the emission of probe changes to deep red gradually with ratiometric fluorescent response due to formation and aggregation of enzymatic product, whose fluorescence involves both excited-state intramolecular proton transfer and aggregation-induced emission processes. The linear ratiometric fluorescent response enables in vitro quantification of ALP activity in a range of 0-150 mU/mL with a detection limit of 0.15 mU/mL. The probe also shows excellent biocompatibility, which enables it to apply in ALP mapping in living cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hong, Y., Lam, J. W. Y., & Tang, B. Z. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15113d · Cited by 6,363
Self-citationRapid Detection of Hydrogen Peroxide Based on Aggregation Induced Ratiometric Fluorescence Change
Li, G., Zhu, D., Liu, Q., Xue, L., & Jiang, H. (2013) · Organic Letters · doi:10.1021/ol4000845 · Cited by 98
Cited by
Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging
Liu, H.-W., Chen, L., Xu, C., Li, Z., Zhang, H., Zhang, X.-B., & Tan, W. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00862g · Cited by 948
Specific light-up bioprobes based on AIEgen conjugates
Liang, J., Tang, B. Z., & Liu, B. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00444b · Cited by 762
Self-citationAggregation-Induced Emission Luminogens for Activity-Based Sensing
Wang, D., & Tang, B. Z. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00305 · Cited by 510
Self-citationPolymeric AIE-based nanoprobes for biomedical applications: recent advances and perspectives
Zhang, X., Wang, K., Liu, M., Zhang, X., Tao, L., Chen, Y., & Wei, Y. (2015) · Nanoscale · doi:10.1039/c5nr01444a · Cited by 508
Fluorescent chemosensors manipulated by dual/triple interplaying sensing mechanisms
He, L., Dong, B., Liu, Y., & Lin, W. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00413j · Cited by 455
Metadata
- Authors
- Song, Z., Kwok, R. T. K., Zhao, E., He, Z., Hong, Y., Lam, J. W. Y., Liu, B., & Tang, B. Z.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-09-24
- Volume
- 6
- Issue
- 19
- Pages
- 17245-17254
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2068615956
- Cited by
- 325
- References
- 2
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Ratiometric Fluorescent Probe Based on ESIPT and AIE Processes for Alkaline Phosphatase Activity Assay and Visualization in Living Cells. https://app.cochat.ai/papers/10.1021/am505150d
- The paper
- Song, Z., Kwok, R. T. K., Zhao, E., He, Z., Hong, Y., Lam, J. W. Y., Liu, B., & Tang, B. Z. (2014). A Ratiometric Fluorescent Probe Based on ESIPT and AIE Processes for Alkaline Phosphatase Activity Assay and Visualization in Living Cells. ACS Applied Materials & Interfaces. https://doi.org/10.1021/am505150d
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
