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PARACEST Agents: Modulating MRI Contrast via Water Proton Exchange
Abstract
Scientific interest in optimizing the properties of gadolinium (III) complexes as MRI contrast agents has led to many new insights into lanthanide ion coordination chemistry in the last two decades. Among these was the surprising observation that water exchange in lanthanide (III) derivatives of DOTA can be modulated dramatically by judicious choice of ligand side chain and Ln(3+) ionic radii. This resulted in the discovery of paramagnetic CEST agents for altering MRI image contrast based upon the chemical exchange saturation transfer mechanism. The goal of this article is to review the factors that govern water molecule and water proton exchange in these complexes and to compare the potential sensitivity of PARACEST agents versus Gd(3+)-based T(1) relaxation agents for altering tissue contrast.
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Citations
Cited by
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Que, E. L., Domaille, D. W., & Chang, C. J. (2008) · Chemical Reviews · doi:10.1021/cr078203u · Cited by 2,061
Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers
Wahsner, J., Gale, E. M., Rodríguez-Rodríguez, A., & Caravan, P. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00363 · Cited by 1,603
Chemical exchange saturation transfer (CEST): what is in a name and what isn't?
van Zijl, P. C. M., & Yadav, N. N. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22761 · Cited by 1,155
New Technologies for Human Cancer Imaging
Frangioni, J. V. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.3065 · Cited by 800
Multimodality Molecular Imaging of Tumor Angiogenesis
Cai, W., & Chen, X. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.045922 · Cited by 494
Metadata
- Authors
- Zhang, S., Merritt, M., Woessner, D. E., Lenkinski, R. E., & Sherry, A. D.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-08-14
- Volume
- 36
- Issue
- 10
- Pages
- 783-790
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2117349353
- Cited by
- 436
- References
- 0
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, S., Merritt, M., Woessner, D. E., Lenkinski, R. E., & Sherry, A. D. (2003). PARACEST Agents: Modulating MRI Contrast via Water Proton Exchange. Accounts of Chemical Research. https://doi.org/10.1021/ar020228m
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