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Nanoparticle Interaction with Biological Membranes: Does Nanotechnology Present a Janus Face?
Open accessAbstract
Polycationic organic nanoparticles are shown to disrupt model biological membranes and living cell membranes at nanomolar concentrations. The degree of disruption is shown to be related to nanoparticle size and charge, as well as to the phase-fluid, liquid crystalline, or gel-of the biological membrane. Disruption events on model membranes have been directly imaged using scanning probe microscopy, whereas disruption events on living cells have been analyzed using cytosolic enzyme leakage assays, dye diffusion assays, and fluorescence microscopy.
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Cited by
Cho, E. C., Xie, J., Wurm, P. A., & Xia, Y. (2009) · Nano Letters · doi:10.1021/nl803487r · Cited by 819
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Wong, P. T., & Choi, S. K. (2015) · Chemical Reviews · doi:10.1021/cr5004634 · Cited by 507
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Bus, T., Traeger, A., & Schubert, U. S. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00967h · Cited by 409
Nanoparticles skin absorption: New aspects for a safety profile evaluation
Larese Filon, F., Mauro, M., Adami, G., Bovenzi, M., & Crosera, M. (2015) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2015.05.005 · Cited by 390
Vasir, J. K., & Labhasetwar, V. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.07.020 · Cited by 268
Metadata
- Authors
- Leroueil, P. R., Hong, S., Mecke, A., Baker, J. R., Orr, B. G., & Banaszak Holl, M. M.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-05-01
- Volume
- 40
- Issue
- 5
- Pages
- 335-342
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2153262958
- Cited by
- 544
- References
- 0
- FWCI
- 11.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Leroueil, P. R., Hong, S., Mecke, A., Baker, J. R., Orr, B. G., & Banaszak Holl, M. M. (2007). Nanoparticle Interaction with Biological Membranes: Does Nanotechnology Present a Janus Face? Accounts of Chemical Research. https://doi.org/10.1021/ar600012y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
