The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Understanding the Role of Surface Charges in Cellular Adsorption versus Internalization by Selectively Removing Gold Nanoparticles on the Cell Surface with a I2/KI Etchant
Abstract
This Letter presents a new method for differentiating the Au nanospheres attached to the cell surface from those being internalized into the cells. We introduced an etching solution based on I2 and KI that can selectively dissolve the Au nanospheres on the cell surface within a short period of time. The advantage of this etchant is its low toxicity to the cells because it is capable of etching away a relatively large amount of Au nanospheres at a low molar concentration. By combining with quantitative elemental analysis, we found that the deposition of Au nanospheres on the surface of cancer cells was highly dependent on the sign of surface charges on the Au nanospheres. In addition, by fitting the uptake data with a kinetic model, we were able to derive the overall and internalization rate constants for Au nanospheres and both of them were found to be governed by the surface charges on Au nanospheres.
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Cites
Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods
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Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells
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In vivo cancer targeting and imaging with semiconductor quantum dots
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Chithrani, B. D., & Chan, W. C. W. (2007) · Nano Letters · doi:10.1021/nl070363y · Cited by 2,286
Role of target geometry in phagocytosis
Champion, J. A., & Mitragotri, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600997103 · Cited by 2,074
Gold Nanoparticles in Biology: Beyond Toxicity to Cellular Imaging
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Cited by
The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems
Albanese, A., Tang, P. S., & Chan, W. C. W. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150124 · Cited by 3,633
Cellular uptake of nanoparticles: Journey inside the cell
Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859
Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake
Walkey, C. D., Olsen, J. B., Guo, H., Emili, A., & Chan, W. C. W. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2084338 · Cited by 1,926
Piao, J.-G., Wang, L., Gao, F., You, Y.-Z., Xiong, Y., & Yang, L. (2014) · ACS Nano · doi:10.1021/nn503779d · Cited by 426
Stimulus responsive nanogels for drug delivery
Zha, L., Banik, B., & Alexis, F. (2011) · Soft Matter · doi:10.1039/c0sm01307b · Cited by 391
Metadata
- Authors
- Cho, E. C., Xie, J., Wurm, P. A., & Xia, Y.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-02-06
- Volume
- 9
- Issue
- 3
- Pages
- 1080-1084
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1970238879
- Cited by
- 819
- References
- 40
- FWCI
- 16.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cho, E. C., Xie, J., Wurm, P. A., & Xia, Y. (2009). Understanding the Role of Surface Charges in Cellular Adsorption versus Internalization by Selectively Removing Gold Nanoparticles on the Cell Surface with a I2/KI Etchant. Nano Letters. https://doi.org/10.1021/nl803487r
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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