Quantification of the force of nanoparticle-cell membrane interactions and its influence on intracellular trafficking of nanoparticles
Open accessAbstract
Understanding the interaction of nanoparticles (NPs) with the cell membrane and their trafficking through cells is imperative to fully explore the use of NPs for efficient intracellular delivery of therapeutics. Here, we report a novel method of measuring the force of NP-cell membrane interactions using atomic force microscopy (AFM). Poly(D,L-lactide-co-glycolide) (PLGA) NPs functionalized with poly-L-lysine were used as a model system to demonstrate that this force determines the adhesive interaction of NPs with the cell membrane and in turn the extent of cellular uptake of NPs, and hence that of the encapsulated therapeutic. Cellular uptake of NPs was monitored using AFM imaging and the dynamics of their intracellular distribution was quantified using confocal microscopy. Results demonstrated that the functionalized NPs have a five-fold greater force of adhesion with the cell membrane and the time-lapse AFM images show their rapid internalization than unmodified NPs. The intracellular trafficking study showed that the functionalized NPs escape more rapidly and efficiently from late endosomes than unmodified NPs and result in 10-fold higher intracellular delivery of the encapsulated model protein. The findings described herein enhance our basic understanding of the NP-cell membrane interaction on the basis of physical phenomena that could have wider applications in developing efficient nanocarrier systems for intracellular delivery of therapeutics.
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Kohori et al. evaluated the structural modifications of thermo-responsive block copolymer micelles after drying at 4°C and 40°C, pointing out the presence of rounded-shape individually dispersed micelles at 4°C in contrast with aggregated systems, often retaining their spherical shape, at the higher temperature.
“For example, Kohori et al. [160] evaluated the structural modifications of thermo-responsive block copolymer micelles after drying at 4 • C and 40 • C, pointing out the presence of rounded-shape individually dispersed micelles at 4 • C in contrast with aggregated systems, often retaining their spherical shape, at the higher temperature.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [160]
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Cites
Detection and localization of single molecular recognition events using atomic force microscopy
Hinterdorfer, P., & Dufrêne, Y. F. (2006) · Nature Methods · doi:10.1038/nmeth871 · Cited by 1,057 · see citing works
Panyam, J., Zhou, W., Prabha, S., Sahoo, S. K., & Labhasetwar, V. D. (2002) · The FASEB Journal · doi:10.1096/fj.02-0088com · Cited by 1,044 · see citing works
Self-citationNanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells
Vinogradov, S. V., Bronich, T. K., & Kabanov, A. V. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00245-9 · Cited by 776 · see citing works
Nanoparticle Interaction with Biological Membranes: Does Nanotechnology Present a Janus Face?
Leroueil, P. R., Hong, S., Mecke, A., Baker, J. R., Orr, B. G., & Holl, M. M. B. (2007) · Accounts of Chemical Research · doi:10.1021/ar600012y · Cited by 544 · see citing works
Biodegradable nanoparticles for cytosolic delivery of therapeutics
VASIR, J., & LABHASETWAR, V (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.06.003 · Cited by 526 · see citing works
Self-citationCharacterization of nanoparticle uptake by endothelial cells
Davda, J. P., & Labhasetwar, V. D. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00923-1 · Cited by 524 · see citing works
Self-citationPolymeric Micelles for Delivery of Poorly Water-Soluble Compounds
Kwon, G. S. (2003) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v20.i5.20 · Cited by 502 · see citing works
Panyam, J., & Labhasetwar, V. D. (2003) · Pharmaceutical Research · doi:10.1023/a:1022219003551 · Cited by 467 · see citing works
Self-citationSahoo, S. K., & Labhasetwar, V. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050032z · Cited by 340 · see citing works
Self-citationPanyam, J., Sahoo, S. K., Prabha, S., Bargar, T. W., & Labhasetwar, V. D. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(03)00295-3 · Cited by 309 · see citing works
Self-citationIndentation and Adhesive Probing of a Cell Membrane with AFM: Theoretical Model and Experiments
Sen, S., Subramanian, S., & Discher, D. E. (2005) · Biophysical Journal · doi:10.1529/biophysj.105.063826 · Cited by 304 · see citing works
Schneider, S. W., Sritharan, K. C., Geibel, J. P., Oberleithner, H., & Jena, B. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.316 · Cited by 269 · see citing works
Putman, C. A. J., van der Werf, K. O., Grooth, B. G. D., van Hulst, N. F., & Greve, J. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80649-6 · Cited by 219 · see citing works
Simple test system for single molecule recognition force microscopy
Riener, C. K., Stroh, C. M., Ebner, A., Klampfl, C. W., Gall, A. A., Romanin, C., Lyubchenko, Y. L., Hinterdorfer, P., & Gruber, H. J. (2003) · Analytica Chimica Acta · doi:10.1016/s0003-2670(02)01373-9 · Cited by 200 · see citing works
Panyam, J., & Labhasetwar, V. D. (2003) · Molecular Pharmaceutics · doi:10.1021/mp034002c · Cited by 195 · see citing works
Self-citationEbner, A., Hinterdorfer, P., & Gruber, H. J. (2007) · Ultramicroscopy · doi:10.1016/j.ultramic.2007.02.035 · Cited by 187 · see citing works
Cross-Linking of Cell Surface Receptors Enhances Cooperativity of Molecular Adhesion
Chen, A. B., & Moy, V. T. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76824-x · Cited by 176 · see citing works
MAPPING CELL WALL POLYSACCHARIDES OF LIVING MICROBIAL CELLS USING ATOMIC FORCE MICROSCOPY
Gad, M., Itoh, A., & Ikai, A. (1997) · Cell Biology International · doi:10.1006/cbir.1997.0214 · Cited by 168 · see citing works
Critical Determinants in PLGA/PLA Nanoparticle-Mediated Gene Expression
Prabha, S., & Labhasetwar, V. D. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000016250.56402.99 · Cited by 151 · see citing works
Self-citationAFM review study on pox viruses and living cells
Ohnesorge, F. M., Hörber, J. K., Häberle, W., Czerny, C., Smith, D. P., & Binnig, G. K. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78250-x · Cited by 120 · see citing works
Designing polymer conjugates as lysosomotropic nanomedicines
Duncan, R. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350056 · Cited by 117 · see citing works
Single-Nanoparticle-Terminated Tips for Scanning Probe Microscopy
Vakarelski, I. U., & Higashitani, K. (2006) · Langmuir · doi:10.1021/la0528145 · Cited by 97 · see citing works
Atomic force microscopy imaging of living cells: progress, problems and prospects
You, H. X., & Yu, L. (1999) · Methods in Cell Science · doi:10.1023/a:1009876320336 · Cited by 85 · see citing works
Schaus, S., & Henderson, E. R. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78153-0 · Cited by 85 · see citing works
Targeting Intracellular Targets
Panyam, J., & Labhasetwar, V. D. (2004) · Current Drug Delivery · doi:10.2174/1567201043334768 · Cited by 83 · see citing works
Self-citationOng, Q. K., & Sokolov, I. Y. (2007) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2007.02.010 · Cited by 80 · see citing works
Interaction of poly(l-lysines) with negatively charged membranes: an FT-IR and DSC study
Schwieger, C., & Blume, A. (2006) · European Biophysics Journal · doi:10.1007/s00249-006-0080-8 · Cited by 75 · see citing works
McNamee, C. E., Pyo, N., & Higashitani, K. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.082420 · Cited by 46 · see citing works
THE NUMBER OF SECRETORY VESICLES REMAINS UNCHANGED FOLLOWING EXOCYTOSIS
Cho, S., Cho, J., & Jena, B. P. (2002) · Cell Biology International · doi:10.1006/cbir.2001.0848 · Cited by 44 · see citing works
Molecular Views and Measurements of Hemostatic Processes Using Atomic Force Microscopy
Marchant, R. E., Kang, I., Sit, P. S., Zhou, Y., Todd, B. A., Eppell, S. J., & Lee, I. (2002) · Current Protein and Peptide Science · doi:10.2174/1389203023380611 · Cited by 37 · see citing works
Comparative three-dimensional imaging of living neurons with confocal and atomic force microscopy
McNally, H. A., Rajwa, B. P., Sturgis, J., & Robinson, J. P. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.08.018 · Cited by 36 · see citing works
McNamee, C. E., Pyo, N., Tanaka, S., Vakarelski, I. U., Kanda, Y., & Higashitani, K. (2006) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2006.01.014 · Cited by 32 · see citing works
Investigating live and fixed epithelial and fibroblast cells by atomic force microscopy
Sinniah, K., Paauw, J. D., & Ubels, J. L. (2002) · Current Eye Research · doi:10.1076/ceyr.24.3.188.8306 · Cited by 20 · see citing works
Pyo, N., Tanaka, S., McNamee, C. E., Kanda, Y., Fukumori, Y., Ichikawa, H., & Higashitani, K. (2006) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2006.09.020 · Cited by 18 · see citing works
Investigating live and fixed epithelial and fibroblast cells by atomic force microscopy
Sinniah, K., Paauw, J. D., & Ubels, J. L. (2002) · Current Eye Research · doi:10.1076/ceyr.25.1.61.9963 · Cited by 16 · see citing works
Szabó, R., Hudecz, F., & Reig, F. (2003) · Journal of Colloid and Interface Science · doi:10.1016/s0021-9797(03)00604-0 · Cited by 12 · see citing works
Nagy, I., Hudecz, F., Alsina, M. A., & Reig, F. (2003) · Biopolymers · doi:10.1002/bip.10494 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
PLGA-based nanoparticles: An overview of biomedical applications
Danhier, F., Ansorena, E., Silva, J. M., Coco, R., Breton, A. L., & Véronique Préat, A. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.01.043 · Cited by 3,884 · see citing works
Effect of Surface Properties on Nanoparticle–Cell Interactions
Verma, A., & Stellacci, F. (2009) · Small · doi:10.1002/smll.200901158 · Cited by 2,621 · see citing works
Sahay, G., Alakhova, D. Y., & Kabanov, A. V. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.01.036 · Cited by 2,181 · see citing works
Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135 · see citing works
The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function
Huang, X., Teng, X., Chen, D., Tang, F., & He, J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.060 · Cited by 1,002 · see citing works
Elsaesser, A., & Howard, C. V. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.09.001 · Cited by 904 · see citing works
Insight into nanoparticle cellular uptake and intracellular targeting
Yameen, B., Choi, W. I., Vilos, C., Swami, A., Shi, J., & Farokhzad, O. C. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.038 · Cited by 789 · see citing works
The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles
Cho, E. C., Zhang, Q., & Younan Xia, A. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.58 · Cited by 721 · see citing works
Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems
Mu, Q., Jiang, G., Chen, L., Zhou, H., Fourches, D., Tropsha, A., & Yan, B. (2014) · Chemical Reviews · doi:10.1021/cr400295a · Cited by 692 · see citing works
Effect of the surface modification, size, and shape on cellular uptake of nanoparticles
Salatin, S., Dizaj, S. M., & Khosroushahi, A. Y. (2015) · Cell Biology International · doi:10.1002/cbin.10459 · Cited by 626 · see citing works
Augustine, R., Hasan, A., Primavera, R., Wilson, R. J., Thakor, A. S., & Kevadiya, B. D. (2020) · Materials Today Communications · doi:10.1016/j.mtcomm.2020.101692 · Cited by 569 · see citing works
PLGA-Based Nanoparticles as Cancer Drug Delivery Systems
Mirakabad, F. S. T., Nejati‐Koshki, K., Akbarzadeh, A., Yamchi, M. R., Milani, M., Zarghami, N., Zeighamian, V., Rahimzadeh, A., Alimohammadi, S., Hanifehpour, Y., et al. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.2.517 · Cited by 543 · see citing works
Fawcett, D., Verduin, J., Shah, M., Sharma, S. B., & Poinern, G. E. J. (2017) · Journal of Nanoscience · doi:10.1155/2017/8013850 · Cited by 265 · see citing works
Engin, A. B., Nikitovic, D., Neagu, M. T., Henrich‐Noack, P., Docea, A. O., Shtilman, M. I., Golokhvast, K. S., & Tsatsakis, A. M. (2017) · Particle and Fibre Toxicology · doi:10.1186/s12989-017-0199-z · Cited by 249 · see citing works
Krol, S., Macrez, R., Docagne, F., Defer, G. L., Laurent, S., Rahman, M., Hajipour, M. J., Kehoe, P. G., & Mahmoudi, M. (2012) · Chemical Reviews · doi:10.1021/cr200472g · Cited by 217 · see citing works
Advances in Lung Cancer Treatment Using Nanomedicines
Sharma, A., Shambhwani, D., Pandey, S., Singh, J., Lalhlenmawia, H., Kumarasamy, M., Singh, S. K., Chellappan, D. K., Gupta, G., Prasher, P., et al. (2022) · ACS Omega · doi:10.1021/acsomega.2c04078 · Cited by 198 · see citing works
Mejías, R., Pérez-Yagüe, S., Gutiérrez, L., Cabrera, L. I., Spada, R., Acedo, P., Serna, C. J., Lázaro, F. J., Villanueva, Á., Morales, M. P., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.008 · Cited by 187 · see citing works
Zhang, X., Dong, Y., Zeng, X., Liang, X., Li, X., Wei, T., Chen, H., Jiang, Y., Mei, L., & Feng, S. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.034 · Cited by 175 · see citing works
Covalent Organic Framework Embedded with Magnetic Nanoparticles for MRI and Chemo-Thermotherapy
Benyettou, F., Das, G., Nair, A. R., Prakasam, T., Shinde, D. B., Sharma, S. K., Whelan, J., Lalatonne, Y., Traboulsi, H., Pasricha, R., et al. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c05381 · Cited by 150 · see citing works
PLGA-based nanoparticles for the treatment of cancer: current strategies and perspectives
Alvi, M., Yaqoob, A., Rehman, K., Shoaib, S. M., & Akash, M. S. H. (2022) · AAPS Open · doi:10.1186/s41120-022-00060-7 · Cited by 150 · see citing works
Carrillo‐Conde, B., Song, E.-H., Chavez-Santoscoy, A. V., Phanse, Y., Ramer‐Tait, A. E., Pohl, N. L. B., Wannemuehler, M. J., Bellaire, B. H., & Narasimhan, B. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200213r · Cited by 144 · see citing works
Cellular uptake, evolution, and excretion of silica nanoparticles in human cells
Chu, Z., Huang, Y., Tao, Q., & Li, Q. (2011) · Nanoscale · doi:10.1039/c1nr10499c · Cited by 144 · see citing works
Leonarduzzi, G., Testa, G., Sottero, B., Gamba, P., & Poli, G. (2009) · Current Medicinal Chemistry · doi:10.2174/092986710789957760 · Cited by 140 · see citing works
Ruenraroengsak, P., Novák, P., Berhanu, D., Thorley, A. J., Valsami‐Jones, E., Gorelik, J., Korchev, Y. E., & Tetley, T. D. (2011) · Nanotoxicology · doi:10.3109/17435390.2011.558643 · Cited by 136 · see citing works
Peetla, C., & Labhasetwar, V. D. (2009) · Langmuir · doi:10.1021/la803361y · Cited by 133 · see citing works
Self-citationYang, Y. L., Zhang, X., & Qiu, L. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.096 · Cited by 132 · see citing works
Smart thermo-triggered squirting capsules for nanoparticle delivery
Liu, L., Wang, W., Ju, X., Xie, R., & Chu, L. (2010) · Soft Matter · doi:10.1039/c002231d · Cited by 130 · see citing works
Escaping the endosome: assessing cellular trafficking mechanisms of non-viral vehicles
Xu, E., Saltzman, W. M., & Piotrowski-Daspit, A. S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.05.038 · Cited by 132 · see citing works
Cai, K., Hou, Y., Li, J., Chen, X., Hu, Y., Luo, Z. Y., Ding, X., Xu, D., & Lai, M. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s38992 · Cited by 129 · see citing works
Atomic Force Microscopy in Characterizing Cell Mechanics for Biomedical Applications: A Review
Li, M., Dang, D., Liu, L., Xi, N., & Wang, Y. (2017) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2017.2714462 · Cited by 129 · see citing works
Transcytosis of Nanomedicine for Tumor Penetration
Liu, Y., Huo, Y., Yao, L., Xu, Y., Meng, F., Li, H., Sun, K., Zhou, G., Kohane, D. S., & Tao, K. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b03211 · Cited by 128 · see citing works
Poly(lactic acid)-based particulate systems are promising tools for immune modulation
Peres, C., Matos, A. I., Conniot, J., Sainz, V., Zupančič, E., Silva, J. M., Graça, L., Gaspar, R. S., Véronique Préat, A., & Florindo, H. F. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.11.012 · Cited by 127 · see citing works
Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy
Wang, X., Qiu, Y., Wang, M., Zhang, C.-H., Zhang, T., Zhou, H., Zhao, W., Zhao, W., Xia, G., & Shao, R. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s274289 · Cited by 126 · see citing works
Biodegradable nanoparticles for intracellular delivery of antimicrobial agents
Xie, S., Tao, Y., Pan, Y., Qu, W., Cheng, G., Huang, L., Chen, D., Wang, X., Liu, Z., & Yuan, Z. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.034 · Cited by 124 · see citing works
Hoskins, C., Cuschieri, A., & Wang, L. (2012) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-10-15 · Cited by 120 · see citing works
Peñaloza, J. P., Márquez‐Miranda, V., Cabaña-Brunod, M., Reyes-Ramírez, R., Llancalahuén, F. M., Vilos, C., Maldonado-Biermann, F., Velásquez, L., Fuentes, J. A., González-Nilo, F. D., et al. (2017) · Journal of Nanobiotechnology · doi:10.1186/s12951-016-0241-6 · Cited by 119 · see citing works
In Vivo Studies of Nanostructure‐Based Photosensitizers for Photodynamic Cancer Therapy
Voon, S. H., Kiew, L. V., Lee, H. B., Lim, S. H., Noordin, M. I., Kamkaew, A., Burgess, K., & Chung, L. Y. (2014) · Small · doi:10.1002/smll.201401416 · Cited by 111 · see citing works
How do polymeric micelles cross epithelial barriers?
Pepić, I., Lovrić, J., & Filipović-Grčić, J. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.04.012 · Cited by 102 · see citing works
Drug delivery systems based on nanoparticles and related nanostructures
Vujačić, A., Bondžić, A. M., & Vasić, V. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105412 · Cited by 96 · see citing works
Saha, K., Bajaj, A., Duncan, B., & Rotello, V. M. (2011) · Small · doi:10.1002/smll.201100478 · Cited by 95 · see citing works
Luo, L., Zhang, X., Hirano, Y., Tyagi, P., Barabás, P., Uehara, H., Miya, T. R., Singh, N., Archer, B. J., Qazi, Y., et al. (2013) · ACS Nano · doi:10.1021/nn305958y · Cited by 94 · see citing works
Bonferoni, M. C., Rossi, S., Sandri, G., & Ferrari, F. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.06.010 · Cited by 92 · see citing works
Transport phenomena of nanoparticles in plants and animals/humans
Anjum, N. A., Rodrigo, M. Á. M., Moulick, A., Heger, Z., Kopel, P., Zítka, O., Adam, V., Lukatkin, A. S., Duarte, A. C., Pereira, E., et al. (2016) · Environmental Research · doi:10.1016/j.envres.2016.07.018 · Cited by 90 · see citing works
Bhattacharjee, S., Ershov, D., Fytianos, K., van der Gucht, J., Alink, G. M., Rietjens, I. M. C. M., Marcelis, A. T. M., & Zuilhof, H. T. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-11 · Cited by 89 · see citing works
Imaging Single Nanoparticle Interactions with Human Lung Cells Using Fast Ion Conductance Microscopy
Novák, P., Shevchuk, A., Ruenraroengsak, P., Miragoli, M., Thorley, A. J., Klenerman, D., Lab, M. J., Tetley, T. D., Gorelik, J., & Korchev, Y. E. (2014) · Nano Letters · doi:10.1021/nl404068p · Cited by 89 · see citing works
Ghosh, P. R., Fawcett, D., Sharma, S., & Poinern, G. E. J. (2017) · Materials · doi:10.3390/ma10080852 · Cited by 89 · see citing works
Mir, A. H., Qamar, A., Qadir, I., Naqvi, A. H., & Begum, R. (2020) · Scientific Reports · doi:10.1038/s41598-020-58526-1 · Cited by 84 · see citing works
Macropinocytosis as a cell entry route for peptide-functionalized and bystander nanoparticles
Li, Y., & Pang, H. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.10.049 · Cited by 84 · see citing works
Pletikapić, G., Žutić, V., Vrček, I. V., & Svetličić, V. (2012) · Journal of Molecular Recognition · doi:10.1002/jmr.2177 · Cited by 84 · see citing works
Wang, C., Ho, P. C., & Lim, L. Y. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.08.023 · Cited by 83 · see citing works
Zhao, S., Dai, W., He, B., Wang, J., He, Z., Zhang, X., & Zhang, Q. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.018 · Cited by 82 · see citing works
Prakash, J., Venugopalan, R., Tripathi, B. M., Ghosh, S. K., Chakravartty, J. K., & Tyagi, A. K. (2015) · Progress in Solid State Chemistry · doi:10.1016/j.progsolidstchem.2015.06.001 · Cited by 81 · see citing works
Zhu, X., Zeng, X., Zhang, X., Cao, W., Wang, Y., Chen, H., Wang, T., Tsai, H., Zhang, R., Chang, D., et al. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.10.016 · Cited by 78 · see citing works
Real-Time Nanoparticle–Cell Interactions in Physiological Media by Atomic Force Microscopy
Pyrgiotakis, G., Blattmann, C. O., & Demokritou, P. (2014) · ACS Sustainable Chemistry & Engineering · doi:10.1021/sc500152g · Cited by 73 · see citing works
Surface charge-specific cytotoxicity and cellular uptake of tri-block copolymer nanoparticles
Bhattacharjee, S., Ershov, D., van der Gucht, J., Alink, G. M., Rietjens, I. M. C. M., Zuilhof, H. T., & Marcelis, A. T. M. (2011) · Nanotoxicology · doi:10.3109/17435390.2011.633714 · Cited by 72 · see citing works
Verma, N. K., Conroy, J., Lyons, P. E., Coleman, J., O'Sullivan, M. P., Kornfeld, H., Kelleher, D., & Volkov, Y. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.08.023 · Cited by 68 · see citing works
Yang, D. H., Kim, H. J., Park, K., Kim, J. K., & Chun, H. J. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1461957 · Cited by 66 · see citing works
Surface Functionalization of Nanoparticles to Control Cell Interactions and Drug Release
Luo, R., Neu, B., & Venkatraman, S. S. (2012) · Small · doi:10.1002/smll.201200398 · Cited by 65 · see citing works
Toxicity of Nanoparticles: Etiology and Mechanisms
Crisponi, G., Nurchi, V. M., Lachowicz, J. I., Peana, M., Medici, S., & Zoroddu, M. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-52733-0.00018-5 · Cited by 62 · see citing works
Tantra, R., & Knight, A. E. (2010) · Nanotoxicology · doi:10.3109/17435390.2010.512987 · Cited by 62 · see citing works
D’Souza, G. G. M., & Weissig, V. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903236101 · Cited by 60 · see citing works
Hu, J., Youssefian, S., Obayemi, J. D., Malatesta, K. A., Rahbar, N., & Soboyejo, W. O. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.02.011 · Cited by 57 · see citing works
Esfandyari‐Manesh, M., Mohammadi, A., Atyabi, F., Nabavi, S. M., Ebrahimi, S. M., Shahmoradi, E., Varnamkhasti, B. S., Ghahremani, M. H., & Dinarvand, R. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.10.066 · Cited by 56 · see citing works
Direct interaction of food derived colloidal micro/nano-particles with oral macrophages
Ke, L., Wang, H., Gao, G., Rao, P., He, L., & Zhou, J. (2017) · npj Science of Food · doi:10.1038/s41538-017-0003-3 · Cited by 55 · see citing works
A Framework to Account for Sedimentation and Diffusion in Particle–Cell Interactions
Cui, J., Faria, M., Björnmalm, M., Ju, Y., Suma, T., Gunawan, S. T., Richardson, J. J., Heidari, H., Bals, S., Crampin, E. J., et al. (2016) · Langmuir · doi:10.1021/acs.langmuir.6b01634 · Cited by 53 · see citing works
The utilization of pathogen-like cellular trafficking by single chain block copolymer
Sahay, G., Gautam, V., Luxenhofer, R., & Kabanov, A. V. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.020 · Cited by 51 · see citing works
Nanomedicine for prostate cancer using nanoemulsion: A review
Sasikumar, A., & Kamalasanan, K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.06.001 · Cited by 51 · see citing works
Kapadia, C. H., Ioele, S. A., & Day, E. S. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36840 · Cited by 54 · see citing works
Cytotoxicity of silica nanoparticles on HaCaT cells
Liang, H., Jin, C. H., Tang, Y., Wang, F., Ma, C.-W., & Yang, Y. (2013) · Journal of Applied Toxicology · doi:10.1002/jat.2953 · Cited by 50 · see citing works
Environmental Risk, Human Health, and Toxic Effects of Nanoparticles
Jamuna, B. A., & Rai, R., V (2014) · doi:10.1002/9781118845530.ch31 · Cited by 48 · see citing works
Yu, C., He, B., Xiong, M., Zhang, H., Yuan, L., Ma, L., Dai, W., Wang, J., Wang, X., Wang, X., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.05.006 · Cited by 47 · see citing works
Jain, A., Shah, S. G., & Chugh, A. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1586-x · Cited by 47 · see citing works
Applications of biosensing atomic force microscopy in monitoring drug and nanoparticle delivery
Lamprecht, C., Hinterdorfer, P., & Ebner, A. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.917078 · Cited by 46 · see citing works
Regulating exocytosis of nanoparticles via host–guest chemistry
Kim, C., Tonga, G. Y., Yan, B., Kim, C. S., Kim, S. T., Park, M., Zhu, Z., Duncan, B., Creran, B., & Rotello, V. M. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob02433h · Cited by 46 · see citing works
Awad, N. S., Salkho, N. M., Abuwatfa, W. H., Paul, V., AlSawaftah, N., & Husseini, G. A. (2023) · OpenNano · doi:10.1016/j.onano.2023.100136 · Cited by 45 · see citing works
The Roles of Cellular Nanomechanics in Cancer
Yallapu, M. M., Katti, K. S., Katti, D. R., Mishra, S. R., Khan, S., Jaggi, M., & Chauhan, S. C. (2014) · Medicinal Research Reviews · doi:10.1002/med.21329 · Cited by 44 · see citing works
Phanse, Y., Carrillo‐Conde, B., Ramer‐Tait, A. E., Roychoudhury, R., Pohl, N. L. B., Narasimhan, B., Wannemuehler, M. J., & Bellaire, B. H. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.06.024 · Cited by 45 · see citing works
Preclinical models and technologies to advance nanovaccine development
Peres, C., Matos, A. I., Moura, L. I. F., Acúrcio, R. C., Carreira, B., Pozzi, S., Vaskovich‐Koubi, D., Kleiner, R., Satchi‐Fainaro, R., & Florindo, H. F. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.001 · Cited by 45 · see citing works
Peetla, C., Rao, K. S., & Labhasetwar, V. D. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900011h · Cited by 44 · see citing works
Self-citationNanoparticles as a potential teratogen: a lesson learnt from fruit fly
Barik, B. K., & Mishra, M. (2018) · Nanotoxicology · doi:10.1080/17435390.2018.1530393 · Cited by 43 · see citing works
Profiling to Probing: Atomic force microscopy to characterize nano-engineered implants
Gulati, K., & ADACHI, T. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.08.006 · Cited by 43 · see citing works
Mo, L., Hou, L., Guo, D., Xiao, X., Mao, P., & Yang, X. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.07.050 · Cited by 43 · see citing works
Effect of Physicochemical Properties of Biodegradable Polymers on Nano Drug Delivery
Sonam, S., Chaudhary, H., Arora, V., Kholi, K., & Kumar, V. (2013) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/15583724.2013.828751 · Cited by 42 · see citing works
Centrifugation-based assay for examining nanoparticle–lipid membrane binding and disruption
Xi, A., & Bothun, G. D. (2013) · The Analyst · doi:10.1039/c3an01601c · Cited by 39 · see citing works
Budiman, A., Rusdin, A., & Aulifa, D. L. (2023) · Antioxidants · doi:10.3390/antiox12020378 · Cited by 39 · see citing works
Lee, H. J., & Bae, Y. (2012) · Pharmaceutical Research · doi:10.1007/s11095-012-0893-3 · Cited by 38 · see citing works
Nanoparticle Permeation Induces Water Penetration, Ion Transport, and Lipid Flip-Flop
Song, B., Yuan, H., Pham, S. V., Jameson, C. J., & Murad, S. (2012) · Langmuir · doi:10.1021/la302879r · Cited by 38 · see citing works
Lim, Y. T., Cho, M. Y., Lee, J. M., Chung, S. J., & Chung, B. H. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.11.007 · Cited by 38 · see citing works
Phytol-Loaded Solid Lipid Nanoparticles as a Novel Anticandidal Nanobiotechnological Approach
Lima, T. L. C., de Souza, L. B. F. C., Tavares-Pessoa, L. C. S., Silva, A. M. D. S., Cavalcante, R. S., de Araujo-Junior, R. F., Cornélio, A. M., Fernandes‐Pedrosa, M. D. F., Chaves, G. M., & da Silva-Júnior, A. A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090871 · Cited by 34 · see citing works
Song, B., Yuan, H., Jameson, C. J., & Murad, S. (2012) · Molecular Physics · doi:10.1080/00268976.2012.668964 · Cited by 34 · see citing works
Huang, N., Yan, Y., Xu, Y., Jin, Y., Lei, J., Zou, X., Ran, D., Zhang, H., Luan, S., & Gu, H. (2012) · Nanotoxicology · doi:10.3109/17435390.2011.648668 · Cited by 34 · see citing works
Daniel, M., Řezníčková, J., Handl, M., Iglič, A., & Kralj‐Iglič, V. (2018) · Scientific Reports · doi:10.1038/s41598-018-28965-y · Cited by 34 · see citing works
Functional Nanomedicines for Targeted Therapy of Bladder Cancer
Tang, C., Liu, H., Fan, Y., He, J., Li, F., Wang, J., & Hou, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.778973 · Cited by 34 · see citing works
Arginine functionalized hydroxyapatite nanoparticles and its bioactivity for gene delivery
Wang, G., Zhao, Y., Tan, J., Zhu, S., & Zhou, K. (2015) · Transactions of Nonferrous Metals Society of China · doi:10.1016/s1003-6326(15)63629-9 · Cited by 33 · see citing works
Light-assisted anticancer photodynamic therapy using porphyrin-doped nanoencapsulates
Kirar, S., Chaudhari, D., Thakur, N. S., Jain, S., Bhaumik, J., Laha, J. K., & Banerjee, U. C. (2021) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2021.112209 · Cited by 33 · see citing works
Permeation of nanocrystals across lipid membranes
Song, B., Yuan, H., Jameson, C. J., & Murad, S. (2011) · Molecular Physics · doi:10.1080/00268976.2011.569511 · Cited by 32 · see citing works
Hydroxyapatite for Biomedicine and Drug Delivery
Ghiasi, B., Sefidbakht, Y., & Rezaei, M. (2019) · Advanced structured materials · doi:10.1007/978-3-030-10834-2_4 · Cited by 32 · see citing works
Nanoparticle-plasma Membrane Interactions: Thermodynamics, Toxicity and Cellular Response
Rodríguez‐Hernández, A. G., Vázquez-Duhalt, R., & Saquero, A. H. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666181112090648 · Cited by 31 · see citing works
Dynamic Factors Controlling Targeting Nanocarriers to Vascular Endothelium
Muzykantov, V. R., Radhakrishnan, R., & Eckmann, D. M. (2011) · Current Drug Metabolism · doi:10.2174/138920012798356916 · Cited by 30 · see citing works
Vanza, J. D., Patel, R. B., & Patel, M. R. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102070 · Cited by 30 · see citing works
- Authors
- Vasir, J. K., & Labhasetwar, V.
- Affiliations
- Cleveland Clinic (US)
- ORCID
- Labhasetwar, Vinod
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 29
- Issue
- 31
- Pages
- 4244-4252
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC2570224
- OpenAlex
- W2041164141
- Cited by
- 268
- References
- 37
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 8 · 2023: 12 · 2022: 13 · 2021: 12 · 2020: 20 · 2019: 16 · 2018: 20 · 2017: 17 · 2016: 23 · 2015: 17 · 2014: 21 · 2013: 19 · 2012: 17
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering
- American Heart Association (0515489Z)
- National Institutes of Health
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Force Microscopy Techniques and Applications
- Keywords
- nanoparticle-cell membrane interaction, adhesion force, intracellular trafficking, PLGA nanoparticles, cellular uptake, endosomal escape, late endosomes, intracellular delivery, nanocarriers, atomic force microscopy
- MeSH terms
- Biological Transport, Biomechanical Phenomena, Cell Membrane, Cell Survival, Cytoplasm, Horseradish Peroxidase, Microscopy, Atomic Force, Intracellular Space, Nanoparticles
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