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Strategy and Tactics in Combinatorial Organic Synthesis. Applications to Drug Discovery
Open accessAbstract
A strategic analysis of various issues which pertain to the enablement of combinatorial organic synthesis to produce libraries of non-polymeric organic molecules is given. Methods and examples of the development of solid-phase organic chemistry and its subsequent application to combinatorial library synthesis for drug discovery is illustrated with successful case studies. The synthetic versatility of resin-bound amino-acid-derived imine intermediates to produces, ?-sultams and pyridines is shown. Use of natural products as key components for creation of combinatorial libraries is presented using Rauwolfia alkaloids and the cephalosporin nucleus as examples.
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Cited by
Studer, A., Hadida, S., Ferritto, R., Kim, S.-Y., Jeger, P., Wipf, P., & Curran, D. P. (1997) · Science · doi:10.1126/science.275.5301.823 · Cited by 470
Mass spectrometry and immobilized enzymes for the screening of inhibitor libraries
Cancilla, M. T., Leavell, M. D., Chow, J., & Leary, J. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220403997 · Cited by 61
Metadata
- Authors
- Gordon, E. M., Gallop, M. A., & Patel, D. V.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 1996-03-13
- Volume
- 29
- Issue
- 3
- Pages
- 144-154
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2950429421
- Cited by
- 268
- References
- 0
- FWCI
- 15.59
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Strategy and Tactics in Combinatorial Organic Synthesis. Applications to Drug Discovery. https://app.cochat.ai/papers/10.1021/ar950170u
- The paper
- Gordon, E. M., Gallop, M. A., & Patel, D. V. (1996). Strategy and Tactics in Combinatorial Organic Synthesis. Applications to Drug Discovery. Accounts of Chemical Research. https://doi.org/10.1021/ar950170u
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
